全文获取类型
收费全文 | 346篇 |
免费 | 4篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
妇产科学 | 1篇 |
基础医学 | 32篇 |
口腔科学 | 41篇 |
临床医学 | 16篇 |
内科学 | 29篇 |
神经病学 | 11篇 |
特种医学 | 14篇 |
外科学 | 133篇 |
综合类 | 16篇 |
预防医学 | 5篇 |
眼科学 | 5篇 |
药学 | 23篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2018年 | 3篇 |
2015年 | 10篇 |
2014年 | 11篇 |
2013年 | 22篇 |
2012年 | 12篇 |
2011年 | 8篇 |
2010年 | 13篇 |
2009年 | 4篇 |
2008年 | 10篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 7篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 12篇 |
1998年 | 4篇 |
1997年 | 10篇 |
1996年 | 4篇 |
1995年 | 8篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 12篇 |
1971年 | 8篇 |
1970年 | 11篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
1965年 | 3篇 |
1964年 | 3篇 |
排序方式: 共有351条查询结果,搜索用时 15 毫秒
81.
82.
The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice
Sheikh Fayaz Ahmad Khairy M.A. Zoheir Mushtaq Ahmad Ansari Hesham M. Korashy Saleh A. Bakheet Abdelkader E. Ashour Othman A. Al-Shabanah Mohammed M. Al-harbi Sabry M. Attia 《Molecular immunology》2015
Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mouse model of carrageenan-induced lung inflammation. A single dose of 5-AIQ (1.5 mg/kg) was administered intraperitoneally (i.p.) 1 h before λ-carrageenan (Cg) administration. We assessed the effects of 5-AIQ treatment on CD25+, GITR+, CD25+GITR+, IL-17+ and Foxp3+ cells which were investigated using flowcytometry in pleural exudates and heparinized blood. We also evaluated mRNA expressions of IL-6, TNF-α, IL-1β, IL-10, CD11a, l-selectin (CD62L), ICAM-1, MCP-1, iNOS and COX-2 in the lung tissue. We further examined the effects of 5-AIQ on the key mediators of inflammation, namely COX-2, STAT-3, NF-kB p65, PARP-1, IkB-α and IL-4 protein expression in the lung tissue using western blotting. The results illustrated that the numbers of T cell subsets, IL-17+ cytokine levels were markedly increased and Foxp3+ production decreased in the Cg group. Furthermore, Cg-induced up-regulation of adhesion molecules, pro-inflammatory mediators and chemokine expressions. Western blot analysis revealed an increased protein expressions of COX-2, STAT-3 NF-kB p65 and PARP-1 and decreased IkB-α and IL-4 in the Cg group. PARP-1 inhibitor via 5-AIQ treatment reverses the action significantly of all the previously mentioned effects. Moreover, histological examinations revealed anti-inflammatory effects of 5-AIQ, whereas Cg-group aggravated Cg-induced inflammation. Present findings demonstrate the potent anti-inflammatory action of the PARP-1 inhibitor in acute lung injury induced by carrageenan. 相似文献
83.
Romana SP; Poirel H; Leconiat M; Flexor MA; Mauchauffe M; Jonveaux P; Macintyre EA; Berger R; Bernard OA 《Blood》1995,86(11):4263-4269
84.
85.
86.
ObjectiveTo investigate the anti-inflammatory activity of the extract of Vernonia amygdalina (V.A).MethodsInflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6 hrs, cutting out the ear quantitated the response. The cut ear was weighed and the increase in weight relative to control group was evaluated.ResultsWhen co-applied with croton oil to the rat ear extract of V.A. produced a reduction in the inflammatory response when croton oil alone was applied to the rat ear. The extract produced (69.1±2.0)% reduction of the inflammatory response produced by croton oil alone, lower than the reduction of the inflammatory response produced by acetyl salicylic acid [(71.1±2.0)%].ConclusionsThis finding suggests that extract of V.A. exhibits anti-inflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers. 相似文献
87.
OA Georgewill UO Georgewill RNP Nwankwoala 《Asian Pacific journal of tropical medicine》2010,3(2):133-135
ObjectiveTo investigate the acute and delayed anti-inflammatory effects of Morning oleifera lam (MOL) crude methanolic extract.MethodsCompared the anti-inflammatory effects of MOL with that of standard anti-inflammatory agents like indomethacin and hydrocortisone using Air Pouch Model.ResultsIn both acute and delayed inflammation, the MOL extract produced dose dependent anti-inflammatory effect [acute IC50= (399.30 ±5.43) mg/kg; delayed IC50= (510.26±4.53) mg/kg]. The order of anti-inflammatory potency for the three drugs was hydrocortisone> indomethacin > MOL.ConclusionsThese observations indicate that MOL possesses potential anti-inflammatory property. 相似文献
88.
Aleisa AM Al-Majed AA Al-Yahya AA Al-Rejaie SS Bakheet SA Al-Shabanah OA Sayed-Ahmed MM 《Clinical and experimental pharmacology & physiology》2007,34(12):1252-1259
1. The present study examined whether propionyl-L-carnitine (PLC) could prevent the development of cisplatin (CDDP)-induced acute renal failure in rats. 2. Forty adult male Wistar albino rats were divided into four groups. Rats in the first group were injected daily with normal saline (2.5 mL/kg, i.p.) for 10 consecutive days, whereas the second group received PLC (250 mg/kg, i.p.) for 10 consecutive days. Animals in the third group were injected daily with normal saline for 5 consecutive days before and after a single dose of CDDP (7 mg/kg, i.p.). Rats in the fourth group received a combination of PLC (250 mg/kg, i.p.) for 5 consecutive days before and after a single dose of CDDP (7 mg/kg, i.p.). On Day 6 following CDDP treatment, animals were killed and serum and kidneys were isolated for analysis. 3. Injection of CDDP resulted in a significant increase in serum creatinine, blood urea nitrogen (BUN), thiobarbituric acid-reactive substances (TBARS) and total nitrate/nitrite (NO(x)), as well as a significant decrease in reduced glutathione (GSH), total carnitine, ATP and ATP/ADP in kidney tissues. 4. Administration of PLC significantly attenuated the nephrotoxic effects of CDDP, manifested as normalization of the CDDP-induced increase in serum creatinine, BUN, TBARS and NO(x) and the CDDP-induced decrease in total carnitine, GSH, ATP and ATP/ADP in kidney tissues. 5. Histopathological examination of kidney tissues from CDDP-treated rats showed severe nephrotoxicity, in which 50-75% of glomeruli and renal tubules exhibited massive degenerative changes. Interestingly, administration of PLC to CDDP-treated rats resulted in a significant improvement in glomeruli and renal tubules, in which less than 25% of glomeruli and renal tubules exhibited focal necrosis. 6. Data from the present study suggest that PLC prevents the development of CDDP-induced acute renal injury by a mechanism related, at least in part, to the ability of PLC to increase intracellular carnitine content, with a consequent improvement in mitochondrial oxidative phosphorylation and energy production, as well as its ability to decrease oxidative stress. This will open new perspectives for the use of PLC in the treatment of renal diseases associated with or secondary to carnitine deficiency. 相似文献
89.
90.