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81.
Kuba H Sato N Uchiyama A Nakafusa Y Mibu R Yoshida K Kuroiwa K Tanaka M 《Surgery today》1999,29(4):375-377
We herein describe a patient with mediastinal lymph node metastases which occurred after both a primary sigmoid colon cancer
and metachronous ovarian metastasis had been resected. The most likely route of metastases to the mediastinum in this case
is the paravertebral venous plexus probably connected to the ovarian metastasis, or so-called remetastasis. This case illustrates
that the mediastinum is thus a possible metastatic site in patients with colon cancer. Surgeons should therefore pay attention
to the mediastinum as well as the lung fields when checking chest X-ray films during a follow-up of patients after a resection
of colon cancer. 相似文献
82.
83.
Masaya Kitamura Kiyomi Matsumiya Mikio Namiki Tomoko Hara Tsukasa Seya Akihiko Okuyama 《Journal of assisted reproduction and genetics》1996,13(8):652-656
Purpose: Membrane cofactor protein (MCP), CD46, whose primary function is to protect host cells from homologous complement, has been presumed to serve as a sperm adhesion molecule for oocytes. The purpose of this study was to clarify the relationship between the properties of MCP expressed on epididymal sperm and their fertilizing ability in a recently developed strategy for assisted reproduction.
Methods: We collected ejaculated sperm from normal subjects and epididymal sperm from vasectomized subjects and patients with congenital absence of the vas deferens. Western blotting and cofactor activity assay were performed to investigated the structural and functional properties of MCP.
Results: Epididymal spermatozoa which showed a reduced fertilizing ability tended to react poorly with antibodies against MCP and also showed low cofactor activity, indicating weak complement regulatory activity compared to that of ejaculated spermatozoa.
Conclusions: MCP is sufficiently expressed in ejaculated sperm in men with a normally developed epididymis but is diminished in epididymal sperm from men with congenital or acquired obstruction of the vas deferens. 相似文献
84.
Tsuyoshi Takada Masaya Kitamura Kiyomi Matsumiya Tsuneharu Miki Hisakazu Kiyohara Mikio Namiki Akihiko Okuyama 《The Journal of urology》1996,156(5):1652-1654
Purpose
We evaluated infrared thermometry for measurement of reflux of blood via the internal spermatic vein.Materials and Methods
The change in scrotal temperature in patients with varicoceles and controls with different positions was measured with an infrared thermometer.Results
Scrotal neck temperature in the patients increased during Valsalva's maneuver with upright position (mean plus or minus standard deviation 34.62 plus/minus 1.20 to 36.05 plus/minus 1.42C), while no statistically significant increase occurred in the controls (32.91 plus/minus 0.92 to 33.42 plus/minus 1.15C). Two weeks after high ligation of the internal spermatic vein the scrotal temperature in the patients decreased to the same level (0.59 plus/minus 0.84C) as in the controls. Using this method 2 subclinical varicoceles were also found on the right side in patients with a left varicocele.Conclusions
Infrared thermometry is noninvasive, rapid and simple for documenting varicoceles, including subclinical disease. 相似文献85.
Shohei Nakamura Yutaka Kobayashi Kazuhiko Tozuka Akihiko Tokue Akira Kimura Chikuma Hamada 《The Journal of urology》1996,156(4):1275-1279
Purpose
Circadian changes in urinary frequency, diuresis and bladder capacity were evaluated in middle-aged and elderly patients.Materials and Methods
A total of 2,703 urinations from 50 men (median age 66 years) was recorded with a 24-hour uroflowmetry system.Results
During a 24-hour period the elderly group showed increased frequency and decreased bladder capacity. No difference was observed in diuresis between the 2 age groups. From midnight to 6 a.m. frequency in the elderly group was significantly greater (p less than 0.01) than that in the middle-aged group.Conclusions
Increased frequency in the elderly group during these hours was primarily due to an increase in diuresis. 相似文献86.
Yoshikazu Noguchi Tatsuo Makino Takaki Yoshikawa Katsutoshi Nomura Kuniyasu Fukuzawa Akihiko Matsumoto Takuko Yamada 《Surgery today》1996,26(1):36-41
This study was conducted to investigate the role of tumor necrosis factor- (TNF-) and interleukin-2 (IL-2) in inducing cancer cachexia, and the results were compared with those obtained from our previous study on Fisher 344 rats with methylcholanthrene-induced sarcoma. Three groups of male Fisher 344 rats received one of the following regimens: 4×104 IU of human recombinant TNF- per rat per day subcutaneously (sc) for 5 consecutive days (n=5), 3.5×105 U human recombinant IL-2 per rat per day sc for 14 consecutive days (n=5), or normal saline (n=5). The activities of both phosphoenolpyruvate carboxykinase (PEPCK) and malic enzyme (ME) were increased slightly in the IL-2 group. Furthermore, LPL activity was significantly increased in the adipose tissue of the TNF group and in the cardiac muscle of the IL-2 group, but not in that of the TNF group. These results show that there is a significant difference between the metabolic alterations seen in the tumor-bearing state and those induced by either TNF- or IL-2 alone. Thus, it is unlikely that IL-2 or TNF- is the sole mediator of cancer cachexia in this tumor and rat model. 相似文献
87.
Akihiko Kimura Tomoji Uda Shoichi Nakashima Haruhiko Ikeda Seiji Yasuda Motoki Osawa Tsutomu Tsuji 《International journal of legal medicine》1993,106(1):1-4
Summary The erythrocyte band 3 (EPB3) variant, band 3 Memphis (EPB3*Memphis), was detected by immunoblotting with a monoclonal antibody to the 41 kDa cytoplasmic N-terminal domain of band 3 without protease treatment of erythrocytes. EPB3*Memphis was also detected by immunoblotting from 3-month-old bloodstains subjected to -chymotrypsin treatment. A population genetic study using this method indicated that the EPB3 variant would be useful for forensic work in Japan, since the frequency of this variant in Japanese (Wakayama prefecture) is relatively high (0.159). 相似文献
88.
Kataoka K Hayakawa T Mushiroi T Wakayama A Yamada K Kuroda R Ioku M 《Restorative neurology and neuroscience》1992,4(5):323-330
We compared the functional and anatomical alterations of somatosensory circuits in the acute (1-3 days after infarct) and chronic (3 months after infarct) stage after subcortical striatal infarct in Wistar rats. Occlusion of the left middle cerebral artery produced subcortical striatal infarct in approximately 69% of the rats. The others developed cortical infarct. The function of the somatosensory circuits was evaluated by [14C]2-deoxyglucose autoradiography during physiological stimulation of the right vibrissae and face. In rats with subcortical infarct, the areas activated by sensory stimulation of the right vibrissae and face, applied 1 and 3 days after occlusion, were reduced compared to sham-operated controls (P < 0.05). In the chronic stage of subcortical infarct, the areas of metabolic activation of the left anterior vibrissal and facial sensory area were increased compared to rats with acute subcortical infarct (P < 0.05). To evaluate the anatomical changes in the somatosensory pathway, at 1 day and 3 months after occlusion, we injected wheat germ agglutinin-horseradish peroxidase solution as an axonal transport substance bilaterally into the anterior vibrissal and facial sensory area. Tract tracing studies in both the acute and chronic stage of subcortical infarct showed a reduction in the peroxidase-positive area in the left thalamus compared to the control hemispheres (P < 0.01). The functional disturbance and recovery of the somatosensory circuits after subcortical infarct are discussed. 相似文献
89.
RATIONALE AND OBJECTIVES: Nitric oxide (NO) regulation of endothelial function is involved in the development of acute lung injury. The role of NO in contrast media-induced increases in pulmonary vascular permeability was investigated in a rat model. METHODS: Nonionic (iohexol) and ionic (ioxaglate) contrast media were intravenously injected at 1.5 mL/min in rats. Pulmonary vascular permeability was evaluated by measuring the amount of Evans blue dye uptake as a quantitative marker of albumin extravasation in lung tissue. RESULTS: Intravenous injections of contrast media at doses of 4 and 6 g I/kg induced a dose-dependent increase in pulmonary vascular permeability. L-Arginine (an NO synthase substrate) and N(G)-nitro-L-arginine (L-NNA) (an NO synthase inhibitor) prevented and aggravated, respectively, the increase in pulmonary vascular permeability induced by the contrast medium. An aggravating action of L-NNA was confirmed by morphological and histological observations, this action being blocked by L-arginine (300 mg/kg) but not by D-arginine. Isosorbide dinitrate (1-20 mg/kg), an NO donor, had a dose-dependent protective effect on ioxaglate-increased vascular permeability. CONCLUSIONS: Our experimental findings suggest that contrast media at high doses produce pulmonary edema by inhibiting endothelial NO production, and nitrovasodilators protect against this adverse effect in rats. 相似文献
90.
Toru Sugiyama Takashi Nishida Akio Kataoka Kan Komai Naofumi Ookura Toshio Oobuchi Michiaki Yakushiji 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(2):92-96
Background We investigated retrospectively the records and tissue samples of patients with primary ovarian transitional cell carcinoma
to determine clinical and pathologic features.
Methods The records of 3 patients with ovarian transitional cell carcinoma were reviewed using data from several imaging techniques:
transvaginal ultrasound, computed tomography, and magnetic resonance imaging. We also determined levels of several tumor marker
molecules; and the level of carbohydrate antigen 125 (CA 125), was examined by means of immunohistochemistry.
Results The tumors of 2 patients were classified as pure trnasitional cell carcinoma; in the remaining patient, as predominantly transitional
cell carcinoma. All tumors were bilateral, and 2 of the 3 tumors formed solid masses. Areas of irregular high intensity signals
were seen in magnetic resonance images of the solid parts of the tumors. All 3 tumors tested positive for CA 125; histochemical
expression was confined to the tumor cell membrane and/or the cytoplasm in all cases. The tumors of all 3 patients tested
negative for carcinoembryonic antigen (CEA), and second-look laparotomies did not reveal any residual neoplasms in any of
the patients. The patients have been in a disease-free state for 34, 42, and 14 months, respectively.
Conclusion Our results suggest that transitional cell carcinomas tend to arise bilaterally and to form solid tumors. Magnetic resonance
imaging was a useful diagnostic modality in these cases. Transitional cell carcinoma was characterized by the presence of
CA 125 and the absence of CEA. 相似文献