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21.
Ashraf Bahgat Heba Abdel‐Aziz Mohamed Raafat Amina Mahdy Aiman S. El‐Khatib Ahmed Ismail Mohamed T. Khayyal 《Fundamental & clinical pharmacology》2008,22(6):693-699
Solanum indicum ssp. distichum is used as a vegetable in some parts of Africa and claimed in folk medicine to guard against cardiovascular disorders. It was of interest to study the potential blood pressure lowering effects of a standardized extract of the fruit. An ethanolic extract of the fruit, standardized to contain > 0.15% chlorogenic acids, was tested orally in both normotensive rats and in those rendered hypertensive by twice daily intraperitoneal injection of NW‐nitro‐l ‐arginine methylester (l ‐NAME) for 1 week. The extract was either given at the same time as l ‐NAME or after the establishment of hypertension. The systolic blood pressure (SBP) was measured non‐invasively using a tail cuff computer‐aided monitoring device. Treatment of normotensive rats with the extract (30–300 mg/kg) for 4 weeks showed no hypotensive effect. Giving the extract (100 and 300 mg/kg) orally once daily during the 1 week hypertension induction period with l ‐NAME prevented the development of hypertension. Administration of the extract orally for 1 week after the establishment of hypertension tended to normalize the blood pressure. Pharmacological evidence for the antihypertensive activity of S. distichum is hereby reported for the first time. The extract showed good prophylactic as well as curative effect against l ‐NAME‐induced hypertension, whereby its content of chlorogenic acids may play a minor role. Other constituents may be responsible for the antihypertensive action. The findings support further development of the extract as a potential therapeutically useful antihypertensive agent. 相似文献
22.
Sven Arke Lang Isabel Brecht Christian Moser Aiman Obed David Batt Hans Juergen Schlitt Edward Kenneth Geissler Oliver Stoeltzing 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2008,393(3):333-341
Background and aims Activation of the mitogen-activated protein kinase–extracellular-signal-regulated kinase (ERK) pathways plays an important
role in the progression of hepatocellular carcinoma (HCC). Importantly, Raf kinases are principal effectors within this oncogenic
signaling cascade. We hypothesized that concomitant inhibition of Raf and vascular endothelial growth factor receptor 2 (VEGFR2)
will affect tumor growth and angiogenesis of HCC.
Materials and methods Human HCC cell lines, endothelial cells (EC), and vascular smooth muscle cells (VSMC) were used. For blocking Raf kinase and
VEGFR2, the small molecule inhibitor NVP-AAL881 (Novartis, USA) was used. Activation of signaling intermediates was assessed
by Western blotting, and changes in cell motility were evaluated in migration assays. Effects of NVP-AAL881 on HCC growth
were determined in a subcutaneous tumor model.
Results NVP-AAL881 disrupted activation of ERK and STAT3 in HCC cells and reduced cancer cell motility. In addition, the migration
of ECs and VSMC was also significantly impaired. In ECs, HCC-conditioned media-induced activation of STAT3 was diminished
by NVP-AAL881 treatment. In vivo, NVP-AAL881 significantly reduced tumor growth, CD31-vessel area, and numbers of BrdU-positive
proliferating tumor cells.
Conclusions Combined inhibition of Raf and VEGFR2 disrupts oncogenic signaling and efficiently reduces tumor growth and vascularization
of HCC. Hence, this strategy could prove valuable for therapy of HCC.
German Society of Surgery, Surgical Forum 2008, Best of Abstracts
Sven Arke Lang and Isabel Brecht contributed equally to this work.
These studies were supported, in part, by the German Cancer Aid (Deutsche Krebshilfe, Max-Eder Programm, Bonn, Germany; O.S.),
and a grant from the University of Regensburg, Medical Faculty (ReForM; O.S.; S.A.L.). 相似文献
23.
The c-myc x E2F-1/p21 interactive gene expression index augments cytomorphologic diagnosis of lung cancer in fine-needle aspirate specimens 总被引:1,自引:0,他引:1
24.
We report on the successful regrafting of a transplanted kidney. The donor kidney was first transplanted into a 32‐year‐old patient with renal atrophy. More than 2 years later, he suffered from severe grand mal seizure with brain edema and the patient met the criteria for brain death. The well‐functioning graft was recovered and subsequently transplanted into a 66‐year‐old woman with chronic glomerular nephritis. Neither the first nor the second recipient experienced any acute rejection. To date, more than 14 years later, she is in good health with excellent graft function. This case report implies that excellent long‐term graft function is viable in a graft reused 2 years after the initial transplantation. 相似文献
25.
26.
Schacherer D Zeitoun M Buttner R Gelbmann C Obed A Schlitt HJ Scholmerich J Kirchner GI 《World journal of gastroenterology : WJG》2007,13(45):6090-6093
We describe the first case of sirolimus-induced drug fever in a female liver transplant recipient, with a history of hepatitis C-induced end-stage liver cirrhosis in 1999. In 2005, six years after transplantation, she developed calcineurin inhibitor-induced renal function impairment. Immunosuppression was switched from tacrolimus to sirolimus. Two days after the intake of sirolimus, she developed daily fever spikes, but no infectious focus was found. Antibiotic therapy had no influence on the fever. After fourteen days, sirolimus was switched back to tacrolimus and the fever disappeared. In history, the patient developed ciclosporin-induced generalized seizures eleven days after liver transplantation, followed by the development of a motoric speech disorder. Magnetic resonance imaging (MRI) findings were consistent with leucoencephalopathy, therefore immunosuppressive therapy was changed from ciclosporin to tacrolimus and the neurologic symptoms improved significantly. Our case is the first reported case of sirolimus-induced drug fever. In addition, the patient showed the rare occurrence of ciclosporin-induced leukencephalopathy with seizures. 相似文献
27.
28.
Martin Bauer Rudolf Karch Friederike Neumann Aiman Abrahim Claudia C. Wagner Kurt Kletter Markus Müller Markus Zeitlinger Oliver Langer 《European journal of clinical pharmacology》2009,65(9):941-946
Purpose The aim of this study was to assess the influence of age on the functional activity of the multidrug efflux transporter P-glycoprotein
(P-gp) at the human blood-brain barrier.
Methods Seven young (mean age: 27 ± 4 years) and six elderly (mean age: 69 ± 9 years) healthy volunteers underwent dynamic (R)-[11C]verapamil (VPM) positron emission tomography (PET) scans and arterial blood sampling. Parametric distribution volume (DV)
images were generated using Logan linearisation, and age groups were compared with statistical parametric mapping (SPM). Brain
regions that SPM analysis had shown to be most affected by age were analysed by a region of interest (ROI)-based approach
using a maximum probability brain atlas, before and after partial volume correction (PVC).
Results SPM analysis revealed significant clusters of DV increases in cerebellum, temporal and frontal lobe of elderly compared to
younger subjects. In the ROI-based analysis, elderly subjects showed significant DV increases in amygdala (+30%), insula (+26%)
and cerebellum (+25%) before PVC, and in insula (+33%) after PVC.
Conclusions Increased VPM DV values in the brains of elderly subjects suggest a decrease in cerebral P-gp function with increasing age. 相似文献
29.
Katsumi Nakata Jina Choo Michael J.S. Hopson Hirotsugu Ueshima J. David Curb Chol Shin Rhobert W. Evans Takashi Kadowaki Teruo Otake Aya Kadota Syaka Kadowaki Katsuyuki Miura Aiman El-Saed Daniel Edmundowicz Kim Sutton-Tyrrell Lewis H. Kuller Akira Sekikawa 《Metabolism: clinical and experimental》2010,59(12):1742-1751
Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index–adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index–adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men. 相似文献
30.