全文获取类型
收费全文 | 1756篇 |
免费 | 80篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 57篇 |
妇产科学 | 15篇 |
基础医学 | 136篇 |
口腔科学 | 39篇 |
临床医学 | 125篇 |
内科学 | 338篇 |
皮肤病学 | 155篇 |
神经病学 | 105篇 |
特种医学 | 43篇 |
外科学 | 390篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 48篇 |
眼科学 | 101篇 |
药学 | 131篇 |
中国医学 | 2篇 |
肿瘤学 | 132篇 |
出版年
2024年 | 1篇 |
2023年 | 30篇 |
2022年 | 58篇 |
2021年 | 133篇 |
2020年 | 64篇 |
2019年 | 84篇 |
2018年 | 92篇 |
2017年 | 47篇 |
2016年 | 78篇 |
2015年 | 73篇 |
2014年 | 102篇 |
2013年 | 103篇 |
2012年 | 175篇 |
2011年 | 146篇 |
2010年 | 89篇 |
2009年 | 68篇 |
2008年 | 90篇 |
2007年 | 74篇 |
2006年 | 71篇 |
2005年 | 47篇 |
2004年 | 54篇 |
2003年 | 51篇 |
2002年 | 32篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 12篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1981年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 1篇 |
排序方式: 共有1840条查询结果,搜索用时 15 毫秒
101.
102.
Musunuri Balaji Tripathy Rina Padhi Sunali Panda Aditya K. Das Bidyut K. 《Clinical rheumatology》2022,41(11):3337-3344
Clinical Rheumatology - The distinction between infection and flare in systemic lupus erythematosus (SLE) has always been a dilemma for clinicians as the clinical and biochemical profiles overlap.... 相似文献
103.
104.
Moursi M Nanda NC Holman W McGiffin D Samal A de Sousa JB 《Echocardiography (Mount Kisco, N.Y.)》1998,15(7):703-707
In this case report, we present the utility of transesophageal echocardiography in the detection of two uncommon complications of left ventricular assist devices: regurgitation of the bioprosthetic valve in the inflow conduit and a tear of a Dacron conduit with hematoma formation and compression of the right ventricular free wall. 相似文献
105.
106.
Samuel Akil Jared M. Newman Neil V. Shah Natasha Ahmed Ajit J. Deshmukh Aditya V. Maheshwari 《Journal of Clinical Orthopaedics and Trauma》2018,9(1):3-6
Metal hypersensitivity (MHS) is a rare complication of total joint arthroplasty that has been linked to prosthetic device failure when other potential causes have been ruled out. The purpose of this review was to conduct an analysis of existing literature in order to get a better understanding of the pathophysiology, presentation, diagnosis, and management of MHS. It has been described as a type IV hypersensitivity reaction to the metals comprising prosthetic implants, often nickel and cobalt-chromium. Patients suffering from this condition have reported periprosthetic joint pain and swelling as well as cutaneous, eczematous dermatitis. There is no standard for diagnosis MHS, but tests such as patch testing and lymphocyte transformation testing have demonstrated utility, among others. Treatment options that have demonstrated success include administration of steroids and revision surgery, in which the existing metal implant is replaced with one of less allergenic materials. Moreover, the definitive resolution of symptoms has most commonly required revision surgery with the use of different implants. However, more studies are needed in order to understand the complexity of this subject. 相似文献
107.
Jonas Pick Aditya Arra Holger Lingel J. Kolja Hegel Magdalena Huber Gopala Nishanth Gerhard Jorch Klaus‐Dieter Fischer Dirk Schlüter Kerry Tedford Monika C. Brunner‐Weinzierl 《European journal of immunology》2014,44(7):2139-2152
Although CD8+ T cells that produce IL‐17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8+ T cells. Here, we show that CTLA‐4 enhances the frequency of IL‐17 in CD8+ T cells, indicating that CTLA‐4 (CD152) specifically promotes Tc17 differentiation. Simultaneous stimulation of CTLA‐4+/+ and CTLA‐4?/? T cells in cocultures and agonistic CTLA‐4 stimulation unambiguously revealed a cell‐intrinsic mechanism for IL‐17 control by CTLA‐4. The quality of CTLA‐4‐induced Tc17 cells was tested in vivo, utilizing infection with the facultative intracellular bacterium Listeria monocytogenes (LM). Unlike CTLA‐4+/+ Tc17 cells, CTLA‐4?/? were nearly as efficient as Tc1 CTLA‐4+/+ cells in LM clearance. Additionally, adoptively transferred CTLA‐4?/? Tc17 cells expressed granzyme B after rechallenge, and produced Tc1 cytokines such as IFN‐γ and TNF‐α, which strongly correlate with bacterial clearance. CTLA‐4+/+ Tc17 cells demonstrated a high‐quality Tc17 differentiation program ex vivo, which was also evident in isolated IL‐17‐secreting Tc17 cells, with CTLA‐4‐mediated enhanced upregulation of Tc17‐related molecules such as IL‐17A, RORγt, and IRF‐4. Our results show that CTLA‐4 promotes Tc17 differentiation that results in robust Tc17 responses. Its inactivation might therefore represent a central therapeutic target to enhance clearance of infection. 相似文献
108.
109.
110.
The purpose of this study is to compare the importance and its superiority of apolipoprotein B (apoB) over conventional lipid profile for predicting risk of acute coronary syndrome in young people of Bangladesh. This case-control study was carried out in Department of Cardiology, of Mymensingh Medical College Hospital within the period from June 2009 to May 2010. A total 50 case of 18-45 years of age with first attack of acute coronary syndrome admitted in coronary care unit and 50 healthy controls of same age and sex distribution were studied. Twenty five (50.0%) of the studied case had hyper apoB condition, those low density lipoprotein cholesterol (LDL-C) level was normal, thus conventional lipid profile underestimated the risk. Among the controls 23(46.0%) with high LDL-C had hyper apoB condition. Hyper-ApoB in these controls may cause acute coronary syndrome in future. The present study shows significant association of apolipoprotein B as an independent determinant and estimation of apoB other than conventional lipid profile may be an alternative tool for predicting risk of development of acute coronary syndrome in young people. 相似文献