全文获取类型
收费全文 | 2512篇 |
免费 | 128篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 56篇 |
妇产科学 | 61篇 |
基础医学 | 275篇 |
口腔科学 | 78篇 |
临床医学 | 172篇 |
内科学 | 459篇 |
皮肤病学 | 25篇 |
神经病学 | 117篇 |
特种医学 | 98篇 |
外科学 | 486篇 |
综合类 | 64篇 |
一般理论 | 4篇 |
预防医学 | 208篇 |
眼科学 | 71篇 |
药学 | 192篇 |
中国医学 | 11篇 |
肿瘤学 | 242篇 |
出版年
2023年 | 36篇 |
2022年 | 85篇 |
2021年 | 92篇 |
2020年 | 61篇 |
2019年 | 82篇 |
2018年 | 90篇 |
2017年 | 64篇 |
2016年 | 68篇 |
2015年 | 73篇 |
2014年 | 97篇 |
2013年 | 120篇 |
2012年 | 193篇 |
2011年 | 215篇 |
2010年 | 120篇 |
2009年 | 97篇 |
2008年 | 157篇 |
2007年 | 171篇 |
2006年 | 136篇 |
2005年 | 156篇 |
2004年 | 118篇 |
2003年 | 114篇 |
2002年 | 82篇 |
2001年 | 15篇 |
2000年 | 10篇 |
1999年 | 9篇 |
1998年 | 11篇 |
1997年 | 11篇 |
1996年 | 14篇 |
1995年 | 19篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 7篇 |
1987年 | 8篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1962年 | 3篇 |
排序方式: 共有2653条查询结果,搜索用时 15 毫秒
41.
The additional utility of two‐dimensional strain in detection of coronary artery disease presence and localization in patients undergoing dobutamine stress echocardiogram 下载免费PDF全文
42.
PurposeTo report the late complications associated with permanent filler injections into the malar area for rejuvenation.MethodsA retrospective case series of three patients who presented with lower eyelid swelling several years following injection of polyalkylimide (Bio-Alcamid) into the malar area.ResultsAll patients presented with lower eyelid swelling which developed as a result of spontaneous migration of filler to the lower eyelid. Iatrogenic migration of the filler from the lower eyelid following a trial to remove resulted in an abscess formation which further complicated the removal.ConclusionsLower eyelid swelling may be one of the late complications associated with the permanent fillers into the malar area. An attempt at removal of filler by aspiration or bimanual expression may result in late migration of the product and the development of eyelid swelling. 相似文献
43.
Pham Daniel Polgar Beata Toth Tunde Jungling Adel Kovacs Norbert Balas Istvan Pal Endre Szabo Dora Fulop Balazs Daniel Reglodi Dora Szanto Zalan Herczeg Robert Gyenesei Attila Tamas Andrea 《Age (Dordrecht, Netherlands)》2022,44(2):785-803
GeroScience - The neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) have been shown in numerous in vitro and in vivo models of Parkinson’s disease (PD)... 相似文献
44.
Mohamed Bekheit Matteo Catanzano Stuart Shand Irfan Ahmed ELSaid ELKayal Gihan Mohamed Shehata Adel Zaki 《Hepatobiliary & pancreatic diseases international : HBPD INT》2019,18(1):4-11
Background
Liver transplant is a potential cure for liver failure and hepatic malignancy but there are many techniques which have been described for vascular reconstruction. This study was to compare the prevalence of non-anastomotic biliary stricture and other surgical complications based on Clavien-Dindo scoring system, in initial portal reperfusion (sequential) versus simultaneous or initial artery reperfusion.Data sources
Meta-analysis of published studies comparing the outcomes of both techniques was carried out. Data search was conducted across the major databases and studies were selected under the guidance of the Cochrane guidelines for systematic reviews and meta-analysis.Results
Seven studies were included to address the primary and the secondary outcomes. No statistical difference was found in the incidence of non-anastomotic biliary strictures (OR?=?0.40; P?=?0.14), regardless of reperfusion technique. The pooled estimate of the Clavien-Dindo grading of complications was not significantly different between the techniques, though Clavien-Dindo II complications were higher in the simultaneous or initial artery reperfusion group than the initial portal reperfusion group (OR?=?2.73; P?=?0.01). Similarly, there was no difference in the operative time, hospital stay and other outcomes addressed in this report.Conclusions
The available evidence suggests that there is no significant difference demonstrated in the rate of non-anastomotic biliary strictures or other complications, between the two techniques, except for Clavien-Dindo II complications. 相似文献45.
Keratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen crosslinking (CXL) with riboflavin and Ultraviolet-A (UVA) is a new technique of corneal tissue strengthening that combines the use of riboflavin as a photo sensitizer and UVA irradiation. Studies showed that CXL was effective in halting the progression of keratoconus over a period of up to four years. The published studies also revealed a reduction of max K readings by more than 2 D, while the postoperative spherical equivalent (SEQ) was reduced by an average of more than 1 D and refractive cylinder decreased by about 1 D. The major indication for the use of CXL is to inhibit the progression of corneal ecstasies, such as keratoconus and pellucid marginal degeneration. CXL may also be effective in the treatment and prophylaxis of iatrogenic keratectasia, resulting from excessively aggressive photo ablation. This treatment has been used to treat infectious corneal ulcers with apparent favorable results. Most recent studies demonstrate the beneficial impact of CXL for iatrogenic ecstasies, pellucid marginal degeneration, infectious keratitis, bullous keratopathy and ulcerative keratitis. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subject to epithelial debridement and the application of a soft contact lens. Formation of temporary corneal haze, permanent scars, endothelial damage, treatment failure, sterile infiltrates, bullous keratopathy and herpes reactivation are the other reported complications of this procedure. 相似文献
46.
Chao Gao Piotr Buszman Paweł Buszman Ply Chichareon Rodrigo Modolo Scot Garg Kuniaki Takahashi Hideyuki Kawashima Rutao Wang Chun Chin Chang Norihiro Kogame Mariusz Tomaniak Masafumi Ono Hironori Hara Ton Slagboom Adel Aminian Christoph Kurt Naber Didier Carrie Aleksander Zurakowski 《The Canadian journal of cardiology》2021,37(1):122-130
BackgroundRadial artery access has been shown to reduce mortality and bleeding events, especially in patients with acute coronary syndromes. Despite this, interventional cardiologists experienced in femoral artery access still prefer that route for percutaneous coronary intervention. Little is known regarding the merits of each vascular access in patients stratified by their risk of bleeding.MethodsPatients from the Global Leaders trial were dichotomized into low or high risk of bleeding by the median of the PRECISE-DAPT score. Clinical outcomes were compared at 30 days.ResultsIn the overall population, there were no statistical differences between radial and femoral access in the rate of the primary end point, a composite of all-cause mortality, or new Q-wave myocardial infarction (MI) (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.42-1.15). Radial access was associated with a significantly lower rate of the secondary safety end point, Bleeding Academic Research Consortium (BARC) 3 or 5 bleeding (HR 0.55, 95% CI 0.36-0.84). Compared by bleeding risk strata, in the high bleeding score population, the primary (HR 0.47, 95% CI 0.26-0.85; P = 0.012; Pinteraction = 0.019) and secondary safety (HR 0.57, 95% CI 0.35-0.95; P = 0.030; Pinteraction = 0.631) end points favoured radial access. In the low bleeding score population, however, the differences in the primary and secondary safety end points between radial and femoral artery access were no longer statistically significant.ConclusionsOur findings suggest that the outcomes of mortality or new Q-wave MI and BARC 3 or 5 bleeding favour radial access in patients with a high, but not those with a low, risk of bleeding. Because this was not a primary analysis, it should be considered hypothesis generating. 相似文献
47.
Al-Herz Adeeba Saleh Khuloud Al-Awadhi Adel Al-Kandari Waleed Hasan Eman Ghanem Aqeel Hussain Mohammed Ali Yaser Nahar Ebrahim Alenizi Ahmad Hayat Sawsan Abutiban Fatemah Aldei Ali Alhajeri Hebah Alhadhood Naser Bahbahani Husain Tarakmeh Hoda Mokaddem Khaled Khadrawy Ahmad Fazal Ammad Zaman Agaz Mazloum Ghada Bartella Youssef Hamed Sally Alsouk Ramia Al-Saber Ahmed 《Clinical rheumatology》2021,40(5):1759-1765
Clinical Rheumatology - Biologics are indicated in rheumatoid arthritis (RA) in case of persistent high disease activity despite conventional disease-modifying anti-rheumatic drugs (cDMARDs) or... 相似文献
48.
Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Yasser El-Sawaf 《World journal of gastroenterology : WJG》2021,27(16):1716-1727
The coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-confirmed cases of SARS-CoV-2. Gastrointestinal manifestations of COVID-19 in children are not rare, with a prevalence between 0 and 88%, and a wide variety of presentations, including diarrhoea, vomiting, and abdominal pain, can develop before, with or after the development of respiratory symptoms. Atypical manifestations such as appendicitis or liver injury could also appear, especially in the presence of multisystem inflammatory disease. In this review, we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis, misdiagnosis, prognosis, and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome, child nutrition, and disease management. 相似文献
49.
Warnholtz A Mollnau H Heitzer T Kontush A Möller-Bertram T Lavall D Giaid A Beisiegel U Marklund SL Walter U Meinertz T Munzel T 《Journal of the American College of Cardiology》2002,40(7):1356-1363
OBJECTIVE: With the present studies we sought to determine how treatment with nitroglycerin (NTG) affects endothelial function, oxidative stress and nitric oxide (NO)-downstream signaling in Watanabe heritable hyperlipidemic rabbits (WHHL). BACKGROUND: In vitro experiments have demonstrated potent antiatherosclerotic effects of NO suggesting that treatment with NO-donors such as NTG could compensate for the diminished availability of endothelial NO. Nitric oxide may, however, not only be scavenged by reaction with endothelium-derived superoxide but also form the potent oxidant and inhibitor of vascular function, peroxynitrite (ONOO(-)). METHODS: Watanabe heritable hyperlipidemic rabbits were treated for three days with NTG patches. Normolipidemic New Zealand White rabbits (NZWR) served as controls. Endothelial function was assessed ex vivo with organ chamber experiments and vascular superoxide was quantified using lucigenin (5 and 250 microM) and CLA-enhanced chemiluminescence. Vascular ONOO(-) formation was determined using nitrotyrosine antibodies. The activity of the cGMP-dependent kinase (cGK-I) was assessed by determining the phosphorylation of vasodilator-stimulated phosphoprotein VASP (P-VASP). RESULTS: Nitroglycerin treatment caused endothelial dysfunction in NZWR and WHHL, associated with an increase in superoxide and ONOO(-) production and a substantial drop in cGK-I activity. In vivo NTG-treatment decreased lipophilic antioxidants (alpha- and beta-carotene) in NZWR and WHHL. Treatment of NZWR with NTG also decreased plasma extracellular superoxide dismutase (EC-SOD)-activity. CONCLUSIONS: Nitroglycerin treatment of WHHL with exogenous NO worsens rather than improves endothelial dysfunction secondary to increased formation of superoxide and/or peroxynitrite leading to decreased cGK-I activity. The decrease in plasma levels of alpha- and beta-carotene may be at least in part due to a decrease in EC-SOD activity. 相似文献
50.
Israa A. Seliem Siva S. Panda Adel S. Girgis Yosra I. Nagy Riham F. George Walid Fayad Nehmedo G. Fawzy Tarek S. Ibrahim Amany M. M. Al‐Mahmoudy Rajeev Sakhuja Zakaria K. M. Abdel‐samii 《Chemical biology & drug design》2020,95(2):248-259
A series of new fluoroquinolone conjugates 8a–g and 9a–f were synthesized via benzotriazole‐mediated synthetic approach with good yield and purity. Some of the synthesized analogs exhibited significant antibacterial properties against Escherichia coli and Staphylococcus aureus with potency higher than that of the parent drugs through in vitro standard bioassay procedure (conjugates 8c and 8d reveal antimicrobial properties with potency 1.9, 61.9, 20.7 and 2.4, 37.1, 8.3 folds relative to the parent antibiotic 6 against E. coli, S. aureus, and Enterococcus faecalis, respectively). The observed experimental data were supported by enzymatic DNA gyrase inhibitory property. Developed BMLR‐QSAR model validates the observed experimental data and recognizes the parameters responsible for the enhanced antibacterial properties. 相似文献