全文获取类型
收费全文 | 359篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
妇产科学 | 12篇 |
基础医学 | 33篇 |
口腔科学 | 5篇 |
临床医学 | 43篇 |
内科学 | 43篇 |
皮肤病学 | 6篇 |
神经病学 | 26篇 |
特种医学 | 7篇 |
外科学 | 84篇 |
综合类 | 6篇 |
预防医学 | 29篇 |
眼科学 | 14篇 |
药学 | 49篇 |
中国医学 | 2篇 |
肿瘤学 | 20篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 14篇 |
2021年 | 23篇 |
2020年 | 14篇 |
2019年 | 23篇 |
2018年 | 27篇 |
2017年 | 22篇 |
2016年 | 27篇 |
2015年 | 24篇 |
2014年 | 25篇 |
2013年 | 22篇 |
2012年 | 43篇 |
2011年 | 32篇 |
2010年 | 12篇 |
2009年 | 12篇 |
2008年 | 14篇 |
2007年 | 8篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 3篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1993年 | 2篇 |
排序方式: 共有392条查询结果,搜索用时 257 毫秒
61.
62.
63.
Atteeq U. Rehman Maryam Najafi Marios Kambouris Lihadh Al‐Gazali Periklis Makrythanasis Abolfazl Rad Reza Maroofian Anna Rajab Zornitza Stark Jill V. Hunter Zeineb Bakey Mari J. Tokita Weimin He Francesco Vetrini Andrea Petersen Federico A. Santoni Hanan Hamamy Kaman Wu Fatma Al‐Jasmi Martin Helmstdter Sebastian J. Arnold Fan Xia Christopher Richmond Pengfei Liu Ehsan Ghayoor Karimiani GholamReza Karami Madani Sebastian Lunke Hatem El‐Shanti Christine M. Eng Stylianos E. Antonarakis Jozef Hertecant Magdalena Walkiewicz Yaping Yang Miriam Schmidts 《Human mutation》2019,40(3):267-280
Next‐generation sequencing (NGS) has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome (WES) and whole genome sequencing (WGS) in four independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter, and thinning of the corpus callosum, we identified four previously unreported homozygous truncating PPP1R21 alleles: c.347delT p.(Ile116Lysfs*25), c.2170_2171insGGTA p.(Ile724Argfs*8), c.1607dupT p.(Leu536Phefs*7), c.2063delA p.(Lys688Serfs*26) and found that PPP1R21 was absent in fibroblasts of an affected individual, supporting the allele's loss of function effect. PPP1R21 function had not been studied except that a large scale affinity proteomics approach suggested an interaction with PIBF1 defective in Joubert syndrome. Our co‐immunoprecipitation studies did not confirm this but in contrast defined the localization of PPP1R21 to the early endosome. Consistent with the subcellular expression pattern and the clinical phenotype exhibiting features of storage diseases, we found patient fibroblasts exhibited a delay in clearance of transferrin‐488 while uptake was normal. In summary, we delineate a novel neurodevelopmental syndrome caused by biallelic PPP1R21 loss of function variants, and suggest a role of PPP1R21 within the endosomal sorting process or endosome maturation pathway. 相似文献
64.
Acebutolol (AC), is a chiral, β -adrenergic blocking agent which possesses partial agonist activity and is metabolized to an equipotent chiral metabolite, diacetolol (DC). The enantiomeric disposition of AC is reported following racemic administration as a single oral (p.o., 50 mg kg−1) or as a multiple thrice daily intravenous (i.v.) or p.o. dosing for four days in male Sprague–Dawley rats (n =6). Enantiomeric concentrations of AC and DC in plasma and urine were determined using a stereospecific HPLC assay. The bioavailabilities of R- and S-enantiomer were 0.40 and 0.39 after single dose administration of AC respectively. These values were increased to 0.51 and 0.53 after multiple dosing. Although no significant differences were found in AUC0–∞ after single i.v. as compared with AUC0–τ after multiple i.v. dosing of AC, the 39 and 45% increase in mean AUC0–τ were found after multiple p.o. dosing over the corresponding AUC0–∞, for the single p.o. dose of AC for R- and S-enantiomer, respectively. The disposition of DC as well as the urinary excretion of metabolite was stereoselective in favor of R-enantiomer after oral administration of AC. These results indicate that AC enantiomers have low availability and moderate extraction through the first-pass metabolism in a rat model. The higher AUC values after p.o. multiple dosing may suggest a saturable first-pass metabolism of AC. © 1998 John Wiley & Sons, Ltd. 相似文献
65.
Increased functional connectivity in the ventral and dorsal streams during retrieval of novel words in professional musicians
下载免费PDF全文
![点击此处可从《Human brain mapping》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eva Dittinger Seyed Abolfazl Valizadeh Lutz Jäncke Stefan Elmer 《Human brain mapping》2018,39(2):722-734
Current models of speech and language processing postulate the involvement of two parallel processing streams (the dual stream model): a ventral stream involved in mapping sensory and phonological representations onto lexical and conceptual representations and a dorsal stream contributing to sound‐to‐motor mapping, articulation, and to how verbal information is encoded and manipulated in memory. Based on previous evidence showing that music training has an influence on language processing, cognitive functions, and word learning, we examined EEG‐based intracranial functional connectivity in the ventral and dorsal streams while musicians and nonmusicians learned the meaning of novel words through picture–word associations. In accordance with the dual stream model, word learning was generally associated with increased beta functional connectivity in the ventral stream compared to the dorsal stream. In addition, in the linguistically most demanding “semantic task,” musicians outperformed nonmusicians, and this behavioral advantage was accompanied by increased left‐hemispheric theta connectivity in both streams. Moreover, theta coherence in the left dorsal pathway was positively correlated with the number of years of music training. These results provide evidence for a complex interplay within a network of brain regions involved in semantic processing and verbal memory functions, and suggest that intensive music training can modify its functional architecture leading to advantages in novel word learning. 相似文献
66.
67.
Elaheh EramiHassan Azhdari-Zarmehri Abolfazl Rahmani Elmira Ghasemi-Dashkhasan Saeed SemnanianAbbas Haghparast 《Pharmacology, biochemistry, and behavior》2012,103(2):212-219
The goals of this study were to evaluate the effects of pretreatment by orexin receptor-1 antagonist on the development of morphine tolerance and physical dependence in rat. Animals were rendered dependent on morphine by subcutaneous (SC) injection of morphine sulfate (10 mg/kg) at set intervals of 12 h for 10 days. Just before the morphine administration, the animals received SB-334867, a selective orexin receptor 1 (OXR1) antagonist. To assess morphine tolerance, the antinociceptive responses of morphine were measured using the warm-water tail immersion test before and after its administration. On day 11, naloxone was injected 2 h after morphine administration and the physical dependence evaluated by quantifying/scoring naloxone-precipitated withdrawal signs for 30 min. The effect of chronic SB-334867 on locomotion was carried out by calculating the number of grid crossings as a measure of locomotor activity. Our findings demonstrated that although morphine-tolerance tended to develop in response to repeated injections of morphine, pre-treatment of OXR1 antagonist prevented this effect, causing a delay in the development of morphine-tolerance. Moreover, co-administration of orexin receptor 1 antagonist with morphine significantly decreased the somatic signs of withdrawal including diarrhea, teeth chattering, jumping, and defecation. Administration of SB-334867 alone or in a chronic co-administration with morphine failed to change locomotor activity. These results suggest that the activation of OXR1 might be involved in the development of morphine tolerance and dependence. 相似文献
68.
Boris Schnorbus Robert Schiewe Mir Abolfazl Ostad Christoph Medler Daniel Wachtlin Philip Wenzel Andreas Daiber Thomas Münzel Ascan Warnholtz 《Clinical research in cardiology》2010,99(2):115-124
Background
Pentaerythritol tetranitrate (PETN) differs from other organic nitrates by the lack of tolerance induction and by antioxidative properties. The purpose of this study was to determine the effect of PETN on endothelial function in patients with coronary artery disease (CAD). We hypothesized that the treatment with PETN improves endothelial function in patients with CAD. 相似文献69.
Secondary chromosome aberrations in de novo acute myeloid leukemia ( AML) are less specific and occur in addition to the primary chromosome abnormalities. Secondary chromosome aberration in acute nonlymphocytic leukemia has been recognized for many years as the most serious long-term complication of malignant disease. Our aim in this study was to focus on patients with AML associated with secondary chromosomal abnormalities in 127 consecutive Iranian leukemia patients. Methotrexate (MTX) cell synchronization and 24h non-stimulated cultures of bone marrow cells were applied to determine the incidence of chromosomal aberrations and association of specific primary and secondary chromosome anomalies according to French American British (FAB) morphological subtypes. The distribution of the secondary changes was clearly non-random. The most frequent numerical changes were -X, - Y, -7, + 8, -10 and + 22 and the most common structural aberrations were i(17q), 9q-, dicentric and marker chromosome. We believe this report is the first for de novo AML patients showing secondary chromosomal abnormalities which are quite non-random. The findings could contribute to widening knowledge of related chromosomal abnormalities. 相似文献
70.
Mohammad Javad ZARE SAKHVIDI Abolfazl BARKHORDARI Maryam SALEHI Shekoofeh BEHDAD Hossein FALLAHZADEH 《Industrial health》2013,51(5):545-551
Applicability of two mathematical models in inhalation exposure prediction (well mixed
room and near field-far field model) were validated against standard sampling method in
one operation room for isoflurane. Ninety six air samples were collected from near and far
field of the room and quantified by gas chromatography-flame ionization detector.
Isoflurane concentration was also predicted by the models. Monte Carlo simulation was used
to incorporate the role of parameters variability. The models relatively gave more
conservative results than the measurements. There was no significant difference between
the models and direct measurements results. There was no difference between the
concentration prediction of well mixed room model and near field far field model. It
suggests that the dispersion regime in room was close to well mixed situation. Direct
sampling showed that the exposure in the same room for same type of operation could be up
to 17 times variable which can be incorporated by Monte Carlo simulation. Mathematical
models are valuable option for prediction of exposure in operation rooms. Our results also
suggest that incorporating the role of parameters variability by conducting Monte Carlo
simulation can enhance the strength of prediction in occupational hygiene decision
making. 相似文献