全文获取类型
收费全文 | 359篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
妇产科学 | 12篇 |
基础医学 | 33篇 |
口腔科学 | 5篇 |
临床医学 | 43篇 |
内科学 | 43篇 |
皮肤病学 | 6篇 |
神经病学 | 26篇 |
特种医学 | 7篇 |
外科学 | 84篇 |
综合类 | 6篇 |
预防医学 | 29篇 |
眼科学 | 14篇 |
药学 | 49篇 |
中国医学 | 2篇 |
肿瘤学 | 20篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 14篇 |
2021年 | 23篇 |
2020年 | 14篇 |
2019年 | 23篇 |
2018年 | 27篇 |
2017年 | 22篇 |
2016年 | 27篇 |
2015年 | 24篇 |
2014年 | 25篇 |
2013年 | 22篇 |
2012年 | 43篇 |
2011年 | 32篇 |
2010年 | 12篇 |
2009年 | 12篇 |
2008年 | 14篇 |
2007年 | 8篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 3篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1993年 | 2篇 |
排序方式: 共有392条查询结果,搜索用时 640 毫秒
31.
The effects of Continuous Care Model on depression, anxiety, and stress in patients on hemodialysis.
This quasi-experimental study was carried out to determine the effects of the Continuous Care Model on stress, anxiety, and depression in patients on hemodialysis in Hamedan, Iran in 2005. Thirty-eight patients were selected randomly and the Depression Anxiety Stress Scale (DASS-21) was used for data collection. Data analysis showed a significant relationship between applying the Continuous Care Model and DASS-21 scores. According to the findings, applying this care model can improve the lives of patients on hemodialysis. 相似文献
32.
33.
34.
35.
Mutation in ADORA1 identified as likely cause of early‐onset parkinsonism and cognitive dysfunction
下载免费PDF全文
![点击此处可从《Movement disorders》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Elham Jaberi PhD Mohammad Rohani MD Gholam Ali Shahidi MD Shahriar Nafissi MD Ehsan Arefian PhD Masoud Soleimani PhD Abolfazl Moghadam MS Mohsen Karimi Arzenani PhD Farid Keramatian MS Brandy Klotzle PhD Jian‐Bing Fan PhD Casey Turk PhD Frank Steemers PhD Elahe Elahi PhD 《Movement disorders》2016,31(7):1004-1011
36.
Ahmed A. Hussein Paul R. May Zhe Jing Youssef E. Ahmed Carl J. Wijburg Abdulla Erdem Canda Prokar Dasgupta Mohammad Shamim Khan Mani Menon James O. Peabody Abolfazl Hosseini John Kelly Alexandre Mottrie Jihad Kaouk Ashok Hemal Peter Wiklund Khurshid A. Guru 《The Journal of urology》2018,199(5):1302-1311
37.
S. Abolfazl Hosseini 《Remote sensing letters.》2016,7(2):101-110
In this letter, we propose a feature extracting technique by using rational function curve fitting. A unique rational function curve is developed to fit the spectral signature of each pixel in a hyperspectral image. Polynomial coefficients in the numerator and denominator of the fitted curve are considered as new extracted features. The main contribution of this letter is utilization of curve-fitting ability in order to classify and compress hyperspectral data. In other words, naturally different curves can be discriminated when they are approximated by rational functions with equal form, but different amounts of coefficients. This rational function curve fitting feature extraction method provides better classification results compared to some common feature extraction algorithms when a maximum likelihood classifier is used. The method also has the ability of lossy data compression since the original data can be reconstructed using the fitted curves. In addition, the proposed algorithm has the possibility to be applied to all pixels of image individually, independently and simultaneously, unlike methods like principal component analysis which need to know all data points to compute the transformation matrix before transforming data points to new feature space. 相似文献
38.
Febrile seizures are the most common form of childhood seizures. Although the literature associates certain micronutrients with febrile seizures, there is limited information about the effects of such micronutrients. This study aimed to determine the relationship between serum selenium level and simple febrile seizures in children. This case-control study was conducted in the Children's Hospital in Qazvin, Iran, in 2008. The serum selenium level of 30 children who experienced simple febrile seizures (case group) was measured and compared with that of 30 febrile children without seizure (control group). The serum selenium level was measured by flame atomic absorption spectrophotometer. Data were analyzed by using t-test. Mean ± standard deviation of serum selenium level in the case and control groups was 44.4 ± 10.9 and 63 ± 9.78 μg/dL, a significant difference (P < 0.001). In the case group, 18/30 patients (60%) had a serum selenium level below the norm of 46?μg/dL, whereas serum selenium level in the entire control group was within the normal range (P < 0.01). The serum selenium level in the children who had simple febrile seizures was significantly lower than in the nonseizure control group. It seems that there is an association between serum selenium deficiency and simple febrile seizures; however, further study is recommended. 相似文献
39.
Warnholtz A Ostad MA Heitzer T Thuneke F Fröhlich M Tschentscher P Schwedhelm E Böger R Meinertz T Munzel T 《Atherosclerosis》2007,194(2):439-445
Activation of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of endothelial dysfunction and atherosclerosis. Studies evaluating the effect of AT1-receptor blockers on endothelial dysfunction in patients with coronary artery disease (CAD) revealed mixed results. Studies addressing the effects of AT1-receptor blockers on the coronary and peripheral function in the same study population, are still lacking. We therefore aimed to test the effects of long-term therapy with the AT1-receptor blocker irbesartan (IRB) on both, the coronary and peripheral endothelial function in patients with CAD. Seventy-two patients with CAD were randomly assigned to double-blinded treatment for 6 months with IRB 300 mg per day or placebo, respectively. Coronary and peripheral endothelial function were measured by intracoronary infusion of acetylcholine (final intracoronary concentration 10(-7.3) to 10(-5.6)M) and by determining flow-dependent dilation (FMD) of the brachial artery, respectively. IRB significantly improved FMD, while no change of coronary endothelial function was observed. Interestingly, plasma levels of N(G),N(G)-dimethyl-arginine, and the isoprostane excretion rate were not modified. IRB treatment improves peripheral but not coronary endothelial dysfunction in patients with CAD. Since reduced FMD of the brachial artery has been shown to be associated with a high-cardiovascular event rate, improvement of FMD by IRB may lead to better prognosis of patients with CAD. 相似文献
40.
Abolfazl Azami Parichehr Pasbakhsh Mohammad Akbari Mohammad Barbarestani Mohammadhosein Ghahremani Mohammadali Shokrgozar Ali Mandegary Amir Kiani Gholamreza Hassanzadeh 《中国神经再生研究》2009,4(12):1068-1072
BACKGROUND: 3, 4-methylenedioxymethamphetamine (MDMA, also known as "ecstasy") has been shown to exhibit neurotoxic effects on the hippocampus. However, exposure to sub-lethal insults of MDMA has been reported to result in neuroprotection. OBJECTIVE: To investigate the effects of MDMA on hippocampal neuronal viability, caspase-3 activity, and mRNA expression of the N-methyI-D-aspartate (NMDA) receptor 2B (NR2B) subunit. DESIGN, TIME AND SETTING: A cytological, in vitro experiment was performed at the Department of Anatomy, School of Medicine, and Department of Toxicology-Pharmacology, Faculty of Pharmacy Tehran University of Medical Sciences in 2008. MATERIALS: MDMA was extracted from ecstasy tablets, which were kindly supplied by the Pharmacology-Toxicology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran. METHODS: Hippocampal neurons were isolated from Wistar rats at gestational day 18. Following primary culture, hippocampal neuronal viability was detected by MTT assay. Varying concentrations of MDMA (100-5 000 μmol/L) were used to determine lethal concentration 50 (LC50), which was around 1 500 μmol/L. Five concentrations of MDMA below 1 500 μmol/L (100, 200, 400, 800, and 1 050 μmol/L) were used for the remaining experiments. After 24 hours of MDMA treatment, NR2B mRNA expression was detected by RT-PCR, and caspase-3 relative activity was determined by colorimetric assay. MAIN OUTCOME MEASURES: Hippocampal neuronal viability, caspase-3 activity, and NR2B mRNA expression. RESULTS: MDMA-induced neurotoxicity in hippocampal neuronal cultures was dose-dependent. In high concentrations (1 000-5 000μmol/L) of MDMA, neuronal viability was decreased. However, with a 500 μmol/L dose of MDMA, neuronal viability was significantly increased (P 〈 0.01). Low concentrations of MDMA (200 and 400μmol/L) significantly decreased caspase-3 activity (P 〈 0.01), whereas high concentrations of MDMA significantly increased caspase-3 activity (P 〈 0.01). NR2B subunit mRNA expression was not significantly altered after 100 -1 050 μmol/L MDMA exposure. CONCLUSION: MDMA exhibits dual effects on hippocampal neuronal viability and caspase-3 activity. These effects are independent from NR2B subunit expression levels. 相似文献