Endoscopic assessment of failed fundoplication: a case for standardization

Background  

Preoperative endoscopic assessment of the failed fundoplication is instrumental in diagnosis and surgical management. Endoscopy is a routine and essential part of the workup for a failed fundoplication, but no clear guidelines exist for reporting endoscopic findings. This study aimed to compare endoscopic findings reported by community physicians (gastroenterologists and surgeons) with the findings of the authors (esophageal center) for patients who underwent reoperative intervention after a previous antireflux procedure.     

MR findings of a rare defect, coronary sinus ASD

The coronary sinus drains the cardiac veins into the right atrium. An unroofed coronary sinus is the least common type of atrial septal defect (<1%). An unroofed coronary sinus also communicates with the left atrium, in addition to its normal communication with the right atrium. This defect is difficult to diagnose. MR provides accurate anatomic details about the location and size of defect. Phase contrast velocity-encoded MR also helps towards quantifying the shunt volume. This case represents classical findings of this rare defect. Our patient first presented in the 8th decade with features of right heart failure.     

Coma blisters with hypoxemic respiratory failure

A 24-year-old woman with quadriplegia was admitted with respiratory failure because of pneumonia. She was on multiple medications including diazepam, oxycodone, and amitriptyline, known to be associated with coma blisters, though she did not overdose on any of them. On hospital day 2, she developed multiple blisters on both sides of her right forearm and hand. Skin biopsy showed eccrine gland degeneration consistent with coma blisters. It was felt that hypoxemia from her pneumonia contributed to the development of these blisters, which occurred on both pressure and non-pressure bearing areas of the arm. Coma blisters are self-limited skin lesions that occur at sites of maximal pressure, mostly in the setting of drug overdose. However, coma blisters may occur with metabolic and neurological conditions resulting in coma.     

Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: a case series

Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.