全文获取类型
收费全文 | 4461篇 |
免费 | 457篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 125篇 |
妇产科学 | 181篇 |
基础医学 | 453篇 |
口腔科学 | 172篇 |
临床医学 | 341篇 |
内科学 | 1046篇 |
皮肤病学 | 203篇 |
神经病学 | 205篇 |
特种医学 | 218篇 |
外国民族医学 | 6篇 |
外科学 | 734篇 |
综合类 | 82篇 |
一般理论 | 1篇 |
预防医学 | 302篇 |
眼科学 | 94篇 |
药学 | 415篇 |
中国医学 | 25篇 |
肿瘤学 | 283篇 |
出版年
2023年 | 25篇 |
2022年 | 139篇 |
2021年 | 214篇 |
2020年 | 133篇 |
2019年 | 213篇 |
2018年 | 253篇 |
2017年 | 201篇 |
2016年 | 206篇 |
2015年 | 212篇 |
2014年 | 256篇 |
2013年 | 283篇 |
2012年 | 344篇 |
2011年 | 387篇 |
2010年 | 243篇 |
2009年 | 202篇 |
2008年 | 197篇 |
2007年 | 193篇 |
2006年 | 156篇 |
2005年 | 172篇 |
2004年 | 152篇 |
2003年 | 108篇 |
2002年 | 104篇 |
2001年 | 25篇 |
2000年 | 27篇 |
1999年 | 37篇 |
1998年 | 20篇 |
1997年 | 20篇 |
1996年 | 26篇 |
1995年 | 15篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 35篇 |
1991年 | 14篇 |
1990年 | 20篇 |
1989年 | 9篇 |
1988年 | 21篇 |
1987年 | 22篇 |
1986年 | 14篇 |
1985年 | 23篇 |
1984年 | 11篇 |
1982年 | 13篇 |
1980年 | 12篇 |
1979年 | 18篇 |
1978年 | 10篇 |
1976年 | 10篇 |
1971年 | 12篇 |
1970年 | 10篇 |
1969年 | 9篇 |
1968年 | 8篇 |
1967年 | 12篇 |
排序方式: 共有4951条查询结果,搜索用时 15 毫秒
61.
BackgroundAside from acute viral hepatitides intracellular cholestasis is seen less often with the use of certain drugs, contrast media, leptospirosis and congenital hyperbilirubinaemias. Types of liver injuries complicating malaria usually take the form of acute hepatitis or haemolytic anaemias rather than cholestasis. We report here a rare presentation where a typical intracellular cholestatic picture complicated malaria falciparum in a patient residing in an endemic area.Patient and methodsA 55 year old bank manager presented with malaria fever and deep jaundice for investigations. CBC, LFT, renal function, coagulation profile, liver function test, viral hepatitis markers for HBV and HCV including PCR, U/S liver, MRI liver, CT brain, full septic screen, thin and thick Giemsa-stained blood films and ICT for malaria, leptospira Abs and ANA.ResultsTotal bilirubin 22 mg/dl, conjugated 19 mg/dl, ALT 49, AST 65, alkaline phosphatase 176 (normal), serum albumin 3.5 mg/dl, INR 0.9, urea 98 mg/dl, creatinine 2.3 mg/dl, Hb 8.8, platelet 263, WBC 11000, MCV 84, Coomb’s test negative, haptoglobulin levels: normal, blood culture: negative, HBVDNA and HCVRNA: negative, ANA: negative, blood film and ICT for malaria: positive then turned negative after artemether treatment, leptospira Abs titres for six species including L haeorragiae at days 7, 14 and 60, were: <1/10 negative. Liver U/S normal, MRCP: normal and CT brain: normal patient fully recovered with anti-malarial agent artemether and short course of renal support (haemofiltration).ConclusionIn cases of severe intracellular cholestasis malaria infection should be considered in the differential diagnosis particularly in malaria endemic localities. This rare complication of a common disorder is potentially treatable. 相似文献
62.
A rare complication of mechanical aortic valve replacement: Separation in the region of the mitral‐aortic intervalvular fibrosa
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mehmet Celik MD Ahmet Güner MD Alev Kılıçgedik MD Sabahattin Gunduz MD Abdulrahman Naser MD Elif Eroglu Büyüköner MD Muzaffer Kahyaoglu MD Cagatay Onal MD Gokhan Kahveci MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(8):1232-1233
A 28‐year‐old man was admitted to our emergency service with a shortness of breath and palpitation. On admission, his blood pressure was high and he was in hypertensive pulmonary edema. His physical examination showed rales in both lungs and pansystolic murmur at mitral focus. His medical history included aortic valve replacement (AVR) because of native aortic valve infective endocarditis. Transthoracic echocardiography (TTE) showed normal functional aortic valve. Color flow imaging demonstrated severe mitral regurgitation with posterior eccentric jet. To examine in detail, transesophageal echocardiography (TEE) and three‐dimensional (3D) echocardiography were performed. TEE disclosed a separation in the subaortic curtain leading to severe mitral regurgitation from the left ventricle to the left atrium. In addition to severe mitral regurgitation with posterior eccentric jet, 26‐mm‐long pouch was seen in mitral‐aortic intervalvular fibrosa (MAIVF) at 120° TEE view. This pouch was separated from the mitral anterior leaflet junction releasing the mitral anterior leaflet and causing prolapse and chorda rupture in the A2 scallop of the mitral anterior leaflet. The MAIVF connects the anterior mitral leaflet to the posterior portion of the aortic annulus. The separation of the MAIVF represents a complication of the aortic valve replacement. 相似文献
63.
Extending the mutation spectrum for Galloway–Mowat syndrome to include homozygous missense mutations in the WDR73 gene
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
64.
65.
Hoiyda A. Abdel Rasol Marianne Samir M. Issac Hadeer Abdel Ghaffar Sherine El-Mously 《Comparative clinical pathology》2014,23(2):419-425
Febrile seizures (FSs) are the most common form of childhood seizures. The higher levels of pro-inflammatory cytokines in children may induce seizures, and alternatively, higher levels of anti-inflammatory cytokines may act as a defense mechanism against seizures. We aimed to investigate whether interleukin (IL)-1β-511 C/T (pro-inflammatory cytokine) (rs16944) and IL-1 receptor antagonist (IL-1Ra) (an anti-inflammatory cytokine) gene polymorphisms could be used as markers for prediction of susceptibility to FSs. The current study included 22 patients with FSs and 22 normal control subjects. All patients were subjected to thorough history taking, full neurological examination, electroencephalography, and peripheral blood sampling for genotype analyses. Detection of IL-1Ra gene polymorphisms was done using polymerase chain reaction (PCR), while a restriction fragment length polymorphism analysis of the PCR products was used for the detection of IL-1β-511 C/T gene polymorphisms. The mean age of onset of first febrile seizures was 15.7 months. Eighteen (81.8 %) cases had the criteria of complex FSs. Frequencies of alleles C and T for IL-1β-511 were 26/44 and 18/44, respectively, in FS patients and 22/44 for both in the control subjects. The CC genotype was significantly more common in the FS patients than in the control group. The IL-1Ra-I homozygote was more frequent in patients with FSs than in healthy controls. The IL-1Ra homozygous I/I and IL-1β-511 CC gene polymorphisms are associated with a higher susceptibility to febrile seizures, which may be useful markers for predicting the development of febrile seizures. 相似文献
66.
Chopard Romain Campia Umberto Morin Lucas Jering Karola S. Almarzooq Zaid I. Snyder Julia Elizabeth Rizzo Samantha Waxman Aaron B. Goldhaber Samuel Z. Piazza Gregory 《Journal of thrombosis and thrombolysis》2022,54(3):449-460
Journal of Thrombosis and Thrombolysis - Multidisciplinary pulmonary embolism (PE) response teams have garnered widespread adoption given the complexities of managing acute PE and provide a... 相似文献
67.
68.
Abdel Raouf Abou El Azm Lobna Abou-Ali Abdel Rahman Kobtan Nagwa Mansour Salwa Tawfik 《Archives of virology》2013,158(3):543-547
Hepatitis C and brucellosis are infectious diseases that occur worldwide, and both are endemic in Egypt. Co-infection with both agents is possible, and this can involve the liver in various ways. In this study, we investigated serum tissue inhibitor metalloproteinase-1 (TIMP-1), viral load, and liver functions in patients co-infected with hepatitis C virus (HCV) before and after brucellosis treatment. Over 3 years, 241 consecutive HCV patients (before interferon therapy was received) with recurrent fever who had occupational contact with animals were tested for brucellosis co-infection by a standard tube agglutination test. In patients with dual infection, viraemia (RT-PCR), TIMP-1 measured by ELISA, and liver functions were assessed and re-evaluated 2 months after brucellosis treatment. The number of patients with HCV/brucellosis co-infection was 32 out of 241 (13.3%). TIMP-1, viraemia, AST, ALT and bilirubin showed significant decrease (improvement) after brucellosis treatment (p < 0.001) but an insignificant difference (p > 0.05) with regard to serum albumin and prothrombin concentration. The study revealed that brucellosis is an important infection in HCV-infected patients and can aggravate the course of disease, suggesting that early treatment and prevention are important. 相似文献
69.
70.