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81.
82.
ITRACONAZOLE VERSUS GRISEOFULVIN IN THE TREATMENT OF TINEA CAPITIS: A DOUBLE-BLIND RANDOMIZED STUDY IN CHILDREN 总被引:3,自引:0,他引:3
SARA LÓPEZ-GÓMEZ M.D. AMALIA DEL PALACIO M.D. Ph.D. JAN VAN CUTSEM M.D. Ph.D. MARIA SOLEDAD CUÉTARA M.D. Ph .D. LUIS IGLESIAS M.D. Ph .D. ANTONIO RODRIGUEZ-NORIEGA M.D. Ph .D. 《International journal of dermatology》1994,33(10):743-747
Background. Tinea capitis is a fungal infection in which topical therapy is often unsuccessful. Griseofulvin has been considered to be a first-line therapy. Other antifungal agents are the azole derivatives. Among these, itraconazole was compared with griseofulvin in children in a double-blind study. Patients and Methods. Thirty-four children and one adult with clinical signs and symptoms of tinea capitis and with positive culture and microscopy for dermatophytes have been included in a double-blind comparison between itraconazole, 100 mg daily, and ultramicronized griseofulvin, 500 mg daily. Both drugs were given for 6 consecutive weeks. The final evaluation was made 8 weeks after the end of treatment to allow the hairs to regrow. Seventeen itraconazole- and 15 griseofulvin-treated patients received the complete 6-week treatment course. Fifteen of these 17 itraconazole patients and 14 of the 15 griseofulvin patients had infections caused by Microsporum canis. Fifteen of 17 patients were cured by itraconazole (88%) and 15 of 17 patients by griseofulvin (88%). One of the patients who discontinued griseofulvin therapy after 4 weeks was clinically and mycologically cured. Two of the original 17 griseofulvin patients discontinued therapy because of vomiting. None of the itraconazole-treated children experienced side effects. Conclusions. Itraconazole is the first azole derivate that matches griseofulvin for the treatment of tinea capitis in children. The drug also appears to be better tolerated than griseofulvin. 相似文献
83.
GIUSEPPE STABILE M.D. FRANCESCO SOLIMENE M.D. † EMANUELE BERTAGLIA M.D. ‡ VINCENZO LA ROCCA M.D. § MICHELE ACCOGLI M.D. ¶ ALBERTO SCACCIA M.D. NATALE MARRAZZO M.D. † FRANCO ZOPPO M.D. ‡ PIETRO TURCO M.D. § ASSUNTA IULIANO M.D. GERGANA SHOPOVA M.D. † CARMINE CIARDIELLO B.S. †† ANTONIO DE SIMONE M.D. § 《Pacing and clinical electrophysiology : PACE》2009,32(S1):S141-S145
Objective: To compare the rates of all-cause mortality in recipients of cardiac resynchronization therapy devices without (CRT-PM) versus with defibrillator (CRT-D).
Methods: Between February 1999 and July 2004, 233 patients (mean age = 69 ± 8 years, 180 men) underwent implantation of CRT-PM or CRT-D devices. New York Heart Association (NYHA) heart failure functional class II was present in 11%, class III in 69%, and class IV in 20% of patients; mean left ventricle ejection fraction (LVEF) was 26.5 ± 6.5 %, 48% presented with idiopathic dilated cardiomyopathy and 49% with ischemic heart disease. Cox multiple variable regression analysis was performed in search of predictors of death.
Results: The clinical characteristics of the 117 CRT-PM and 116 CRT-D recipients were similar, except for LVEF (28.2 ± 6.2% vs 25.0 ± 6.5%, respectively; P < 0.001), and ischemic versus nonischemic etiology of heart failure (41% vs 56%, respectively P = 0.02). Over a mean follow-up of 58 ± 15 months, no significance difference in overall mortality rate was observed between the two study groups. Male sex, NYHA functional class IV, and atrial fibrillation at implant were significant predictors of death.
Conclusions: There was no difference in long-term survival rate among patients with CRT-D versus CRT-PM, although CRT-D more effectively lowered the sudden death rate. Male sex, NYHA functional class IV, and atrial fibrillation predicted the worst prognosis. 相似文献
Methods: Between February 1999 and July 2004, 233 patients (mean age = 69 ± 8 years, 180 men) underwent implantation of CRT-PM or CRT-D devices. New York Heart Association (NYHA) heart failure functional class II was present in 11%, class III in 69%, and class IV in 20% of patients; mean left ventricle ejection fraction (LVEF) was 26.5 ± 6.5 %, 48% presented with idiopathic dilated cardiomyopathy and 49% with ischemic heart disease. Cox multiple variable regression analysis was performed in search of predictors of death.
Results: The clinical characteristics of the 117 CRT-PM and 116 CRT-D recipients were similar, except for LVEF (28.2 ± 6.2% vs 25.0 ± 6.5%, respectively; P < 0.001), and ischemic versus nonischemic etiology of heart failure (41% vs 56%, respectively P = 0.02). Over a mean follow-up of 58 ± 15 months, no significance difference in overall mortality rate was observed between the two study groups. Male sex, NYHA functional class IV, and atrial fibrillation at implant were significant predictors of death.
Conclusions: There was no difference in long-term survival rate among patients with CRT-D versus CRT-PM, although CRT-D more effectively lowered the sudden death rate. Male sex, NYHA functional class IV, and atrial fibrillation predicted the worst prognosis. 相似文献
84.
FEDERICO NARCISI DANIELE CASTELLANI GIUSEPPE DI MARCO ANTONIO FILENI GIUSEPPE PARADISO GALATIOTO ADELE MANCINOTTI CARLO VICENTINI 《International journal of urology》2006,13(3):289-290
Endoscopic management of urolithiasis is one of the commonest urological procedures today. It is usually safe and effective but one of the possible complications is ureteral obstruction. Stone fragmentation after ballistic lithotripsy and ureteral wall perforation could explain the mechanism responsible for this occurrence. We report a case of stone granuloma, occurring after a ballistic ureterolithotripsy. 相似文献
85.
MASSIMO SANTINI CLAUDIO PANDOZI SALVATORE TOSCANO ANTONIO CASTRO GIULIANO ALTAMURA ANNA PATRIZIA JESI GIUSEPPE GENTILUCCI MAURO VILLANI MARIA GARMELA SCIANARO 《Pacing and clinical electrophysiology : PACE》1998,21(12):2641-2650
The aims of the study were to verify the efficacy and safety of low energy internal Cardioversion (LEIC) in patients with persistent at rial fibrillation (AF) and to identify the factors affecting the at rial defihrillation threshold (ADT). Forty-nine patients with persistent (lasting ≥ 10 days) AF underwent LEIC. In each patient, two 6 Fr custom-made catheters with large active surface areas were positioned in the coronary sinus (cathode) and the lateral right wall (anode), respectively, for shock delivery, and a tetrapolar lead was placed in the fight ventricular apex for R wave synchronization. Truncated, biphasic (3 ms+3 ms). exponential shocks were used, beginning at 50 V and increasing in steps of 50 V until sinus rhythm had been restored. Mild sedation (diazepam 5 mg IV) was administered to 12 patients. Sinus rhythm was restored in all the subjects with mean voltage and energy levels of 352.0 ± 80.3 V and 8.2 ± 3.4 J, respectively. The ADT in patients pretreated with amiodarone (6.4 ± 1.8 J) was lower than that of patients who had not received any antiarrhythmic drugs (9.2 ± 3.7) (P = 0.04). No ventricular arrhythmias were induced by any of the atrial shocks, and no other complications were observed. During a mean follow-up of 162.9 ± 58.7 days, AF recurred in 21 (43%) patients; 71% of these occurred in the first week after Cardioversion. LEIC is effective in restoring sinus rhythm in patients with persistent AF. The technique seems to be safe and does not require general anesthesia or, in most cases, sedation. Patients pretreated with amiodarone have lower ADTs. 相似文献
86.
87.
GAETANO ANTONIO LANZA MICHELE LUCENTE ANTONIO GIUSEPPE REBUZZI ANTONIO SPAGNOLO CALOGERO DULCIMASCOLO UGO MANZOLI 《Pacing and clinical electrophysiology : PACE》1986,9(6):860-867
Previous works have reported circadian rhythms for several cardiovascular parameters. A chronobiologic rhythm is characterized by: mesor (a rhythm-determined average), amplitude (half difference between the highest and lowest values), and acrophase (timing of high point in degrees and/or in hours) along with 95% confidence limits. We performed 24-hour ECG Holler monitoring in seven patients (mean age, 50.6 years) with ventricular parasystole (VP) in order to determine whether the chronotropic activity of parasystolic foci has a circadian rhythm similar to that of the sinus node. For each Holter recording parasystolic rates (PRs) and heart rates (HRs) were calculated every hour. Furthermore, a mean hourly PR and a mean hourly HR were calculated from the hourly PRs and HRs of the patients. The statistic chronobiologic analysis was done by single and mean cosinor methods. Correlation between mean hourly PR and HR was evaluated by Pearson's V coefficient. A statistically significant rhythm (P < 0.05) was found for the single and mean rhythms both of HR and PR. In our patients, HR had acrophase at 1.27 P.M., mesor at 73.28 beats/min, and amplitude at 9.53 beats/min, whereas PR had acrophase at 1.42 P.M., mesor al 38.31 beats/min, and amplitude at 3.64 beats/ min. Chronobiological data and the high direct correlation between mean hourly HRs and mean hourly PRs (r = 0.96, P < 0.001) indicate a similar circadian variability of the chronotropic activity of sinus nodes and parasystolic foci. Although several hypotheses can be made, responsiveness of parasystolic foci to circadian variations of the autonomic nervous system tone (sympathetic and/or vagal) and/or circulating substances (particularly catecholamines) seems the more probable one for explaining our findings. 相似文献
88.
MENDENHALL CHARLES; CHEDID ANTONIO; ROUSTER SUSAN; KROMME CAROL; GROSSMANI CHARLES; MORGAN DAVID 《Alcohol and alcoholism (Oxford, Oxfordshire)》1987,22(4):375-388
Chronic ethanol effect on regenerating post-partial hepatectomyrat liver was studied from 0 to 80 hr to evaluate sequentialchanges. The rate of restoration in liver mass was comparablebetween controls (C) and ethanol (E) treated rats. Cell cyclechanges included a decrease in magnitude and duration of theearly peak in DNA synthesis (24 hr). However, the second peak(40 hr) was increased in magnitude so that the net change wasnegligible. Histone synthesis increased markedly, whereas thymidinekinase activity was moderately increased. The net effect wasan accelerated accumulation of DNA (0.18 mg of DNA/g liver/hrvs 0.29 mg of DNA/g liver/hr; C vs E). The M phase of the cellcycle was initially delayed by ethanol, but once initiated,it exhibited greater numbers of mitoses reaching significanceat 72 hr. It is concluded that although ethanol induces multiplechanges, the overall process of restoring liver mass and cellnumber (DNA synthesis) is not impaired. 相似文献
89.
90.
ANTONIO MICHELUCCI LUIGI PADELETTI MARCO FRATI SIMONE MININNI REA CHELUCCI M. LETIZIA STOCHINO IGNAZIO SIMONETTI GRISTINA GIGLIOLI MASSIMO MARGHERI GIAN FRANCO GENSINI 《Pacing and clinical electrophysiology : PACE》1996,19(11):1905-1908
The effects of ischemia and reperfusion on QT interval dispersion (QTD: QTmax -QTmin in the 12-lead ECG) were analyzed in 15 patients (12 males, 57 ± 13 years) undergoing coronary angiopiasty (PTCA). AH patients had single-vessel coronary artery disease (only one ≥ 85% stenosis in a major coronary artery) and normal left ventricular function. AH were in sinus rhythm with normal atrioventricular and intraventricular conduction on the surface ECG. No patient was on therapy that could affect the QT interval. The ECG was recorded (all 12 leads simultaneously) at 50 mm/s speed before the first balloon inflation, at the end of the first inflation during PTCA, and at 30" and 60" during reperfusion following the first inflation. In order to avoid ischemic preconditioning, only recordings of the first inflation were used. In each tracing QTmax and QTmin were evaluated. All values were rate corrected using a simple linear equation (QT linear corrected = QT + 0.154 [1-RR]). QTD increased significantly during both ischemia and reperfusion. QTmax was not changed by ischemia and was increased by reperfusion. QTmin was reduced by ischemia and increased by reperfusion. These results indicate that both ischemia and reperfusion alter ventricular repolarization, inducing a less homogeneous ventricular recovery pattern. 相似文献