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31.
YOSHIHIRO YAMASHINA M.D. TETSUO YAGI M.D. Ph.D. AKIO NAMEKAWA M.D. AKIHIKO ISHIDA M.D. HIROKAZU SATO M.D. TAKASHI NAKAGAWA M.D. MANJIROU SAKURAMOTO M.D. EIJI SATO M.D. TOMOYUKI YAMBE M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2012,35(12):e349-e352
A 58‐year‐old man was referred to our emergency room with hemodynamically unstable sustained ventricular tachycardia (VT). The morphology of the VT exhibited a left bundle branch block and inferior axis deviation. He had no past history of cardiovascular disease. Echocardiography, cardiac catheterization, cardiac biopsy, gallium scintigram, myocardial scintigram, T1,T2‐weighted magnetic resonance imaging (MRI), and gadolinium‐enhanced cine MRI did not detect any structural heart disease or abnormal cardiac function. However, delayed‐enhancement MRI (DE‐MRI) detected a focal intramural scar within the septal ventricular outflow tract. An electrophysiological study revealed a sustained VT with several morphologies and the entrainment phenomenon. Radiofrequency catheter ablation to the site corresponding to the focal scar detected by DE‐MRI successfully eliminated the VT. (PACE 2012;35:e349–e352) 相似文献
32.
MICHIHISA ZENMYO SETSURO KOMIYA RIKIMARU KAWABATA YASUYUKI SASAGURI AKIO INOUE MINORU MORIMATSU 《The Journal of pathology》1996,180(4):430-433
The purpose of this study was to investigate the mechanism of cell death in chondrocytes of the growth plate. In the degenerative chondrocyte zone of the growth plate, apoptotic chondrocytes were defeated by the in situ nick end labelling method, by DNA analysis in agarose gel, and by electron microscopy. The results of the in situ nick end labelling method and the occurrence of a ladder pattern of DNA in agarose gel analysis indicated the activation of endogenous endonucleases, resulting in DNA fragmentation. Electron micrographs showed the early morphological changes associated with apoptosis. This report presents both morphological and biochemical evidence for apoptosis in the terminal hypertrophic chondrocytes of the growth plate. These data suggest that apoptosis of degenerative chondrocytes may play an important role in the control of normal and pathological endochondral ossification. 相似文献
33.
Mosaic expression of uncein and 180-kDa bullous pemphigoid antigen in generalized atrophic benign epidermolysis bullosa 总被引:2,自引:0,他引:2
Y. MATSUMURA Y. HORIGUCHI K. TODA H. FUJII S. KORE-EDA T. TACHIBANA K. OHTA H. OKAMOTO S. IMAMURA 《The British journal of dermatology》1997,136(5):757-761
Immunofluorescence microscopy of epidermodermal junction components in serial cryosections from the perilesional skin of a patient with generalized atrophic benign epidermolysis bullosa (GABEB) showed broken line-like staining of both BPAG2 (180-kDa bullous pemphigoid antigen) and uncein (antigen of 19-DEJ-l monoclonal antibody), whereas integrin α6 and laminin 5 were continuously expressed along the basement membrane zone. Immunoelectron microscopy revealed a mosaic distribution of the BPAG2/uncein positive and negative cells. BPAG2, a candidate protein of GABEB, probably has a close connection with uncein, an anchoring filament component. 相似文献
34.
MASAMITSU ADACHI M.D. Ph.D. OSAMU IGAWA M.D. Ph.D. AKIO YANO M.D. Ph.D. JUNICHIRO MIAKE M.D. Ph.D. YOSHIAKI INOUE M.D. Ph.D. KAZUYOSHI OGURA M.D. Ph.D. MASARU KATO M.D. Ph.D. KAZUHIKO IITSUKA M.D. Ph.D. ICHIRO HISATOME M.D. Ph.D. † 《Pacing and clinical electrophysiology : PACE》2009,32(S1):S182-S185
Aims: The His bundle electrogram is believed to reflect the exact location of the His bundle. However, the distinction between distal His bundle potential and proximal right bundle branch potential is challenging. The aim of this study was to pinpoint the location of the branching point of the His bundle, and to compare that site with the site of recording of the largest His bundle electrogram (LH) during sinus rhythm.
Methods: We hypothesized that the site of earliest His activation (EH) during retrograde conduction via the left bundle branch is the branching point. We studied 15 nonconsecutive patients (mean age = 40 ± 22 years; eight men). We performed a programmed stimulation from right ventricular apex until retrograde right bundle branch block appeared. At that point we measured (1) the distance between antegrade LH site and retrograde EH site and (2) the atrial-to-ventricular amplitude ratio (A/V ratio) at both sites.
Results: EH was recorded at the proximal electrode of the His bundle catheter in all patients. Mean distance between EH and LH was 9.8 ± 2.5 mm. The mean A/V ratios at the EH site and the LH site were 1.01 ± 0.42 and 0.08 ± 0.06, respectively.
Discussion: This study showed that the EH site is located approximately 10-mm proximal to the LH site. The mean A/V ratio at the EH site during sinus rhythm is approximately 1.0. These observations suggest that the majority of His potentials reflect proximal right bundle activation. Before delivering radiofrequency energy in the para-Hisian area, attention should be paid to the presence of a His potential and to the A/V ratio, rather to the amplitude of the His electrogram. 相似文献
Methods: We hypothesized that the site of earliest His activation (EH) during retrograde conduction via the left bundle branch is the branching point. We studied 15 nonconsecutive patients (mean age = 40 ± 22 years; eight men). We performed a programmed stimulation from right ventricular apex until retrograde right bundle branch block appeared. At that point we measured (1) the distance between antegrade LH site and retrograde EH site and (2) the atrial-to-ventricular amplitude ratio (A/V ratio) at both sites.
Results: EH was recorded at the proximal electrode of the His bundle catheter in all patients. Mean distance between EH and LH was 9.8 ± 2.5 mm. The mean A/V ratios at the EH site and the LH site were 1.01 ± 0.42 and 0.08 ± 0.06, respectively.
Discussion: This study showed that the EH site is located approximately 10-mm proximal to the LH site. The mean A/V ratio at the EH site during sinus rhythm is approximately 1.0. These observations suggest that the majority of His potentials reflect proximal right bundle activation. Before delivering radiofrequency energy in the para-Hisian area, attention should be paid to the presence of a His potential and to the A/V ratio, rather to the amplitude of the His electrogram. 相似文献
35.
KEICHO NAOTO; SAIJO NAGAHIRO; SHINKAI TETSU; EGUCHI KENJI; SASAKI YASUTSUNA; TAMURA TOMOHIDE; SAKURAI MASANORI; SANO TETSURO; HOSHI AKIO 《Japanese journal of clinical oncology》1986,16(2):143-146
A phase II study of UFT (a mixture of uracil and tegafur; molarratio of uracil to tegafur = 4) was undertaken in 21 patientswith advanced non-small cell lung cancer (NSCLC). UFT was administeredorally at a dose of 400 mg/m2 every day, for more than fourweeks. Of 16 adequately treated patients, one (6.3%) showed a partialresponse. Toxic effects included minimal myelosuppression, anorexia,nausea, vomiting and epigastralgia. Gastrointestinal toxicitywas well tolerated. Considering the poor response and mild toxicity,a further phase II study of higher-dose UFT is necessary forpatients without prior therapy. 相似文献
36.
FUJITA JIRO; SAIJO NAGAHIRO; SASAKI YASUTSUNA; SAKURAI MASANORI; SANO TETSURO; ISHIHARA JUNICHI; TAKAHASHI HIDENOBU; HOSHI AKIO 《Japanese journal of clinical oncology》1985,15(4):589-594
Natural killer (NK) and lymphokine activated killer (LAK) cellactivities in 133 healthy volunteers were analyzed with regardto the volunteer's sex, age, smoking history and the familialincidence of cancer. None of these factors had any influence on NK and LAK cell activities.It was concluded that identifying individuals with increasedrisk of cancer development by examining NK and LAK activitieswould be difficult. 相似文献
37.
38.
Recto-peritoneal fistula following transperineal prostate biopsy 总被引:1,自引:0,他引:1
TAKEO NOMURA HIROMITSU MIMATA SHINROU HATA MUTSUSHI YAMASAKI EIICHI TANAKA TSUYOSHI NOGUCHI AKIO MIZUTANI SHIGENORI YOSHITAKE TAKAYUKI NOGUCHI YOSHIO NOMURA 《International journal of urology》2005,12(3):322-324
A recto-peritoneal fistula is an extremely rare complication after prostate biopsy. We report herein on a peritonitis arising from a recto-peritoneal fistula 5 days after undergoing prostate biopsy. To our knowledge, this is the first case of recto-peritoneal fistula following transperineal needle biopsy of the prostate in the published literature. 相似文献
39.
Histological findings in asymptomatic hepatitis C virus carriers 总被引:1,自引:0,他引:1
TOSHINORI KODAMA TOMOHIRO TAMAKI SHIGEO KATABAMI AKIO KATAMUMA KENTARO YAMASHITA NAOKI AZUMA KEIICHI KAMIJO HIROSHI KINOSHITA AKIRA YACHI 《Journal of gastroenterology and hepatology》1993,8(5):403-405
There is controversy about clinical management of individuals who persistently have hepatitis C virus antibodies (HCVAb) but who have no symptoms or signs of liver disease. Liver biopsy samples were taken from 15 individuals, all of whom had normal alanine aminotransferase (ALT) levels, to determine the prevalence of liver disease and whether HCVAb and HCV-RNA correlate with histological findings. Eleven patients with hepatitis C viremia had histological evidence of chronic hepatitis on biopsy. On the other hand, four HCV-RNA-negative individuals had almost normal liver histology. These findings indicate that serum HCV-RNA is a sensitive and specific marker of liver disease in HCVAb-positive subjects, independent of ALT levels. Furthermore, these results suggest that there are very few histologically healthy carriers of HCV among HCV-RNA-positive individuals. 相似文献
40.