Effects of lesions in the dorsal or ventral striatum on locomotor activity and on locomotor effects of amphetamine

Bilateral electrolytic lesions in the dorsal portion of the anterior striatum of adult male rats reliably increased spontaneous wheel running, and potentiated the stimulant effects of d,1-amphetamine on activity in both running wheels and stabilimeters. Comparable lesions in the ventral aspects of the striatum produced a decrease in spontaneous wheel running and did not modify the activating effects of amphetamine in either wheels or stabilimeters.     

Effect of decreased O2 supply to tissue on the lactate:pyruvate ratio in blood

Experiments were performed with trained conscious dogs with permanently implanted intravascular catheters. With the dogs in a basal resting state, the concentrations of lactate (L) and pyruvate (P) in arterial blood fluctuated widely from day to day, whereas their concentration ratio (L/P) remained relatively constant. By contrast, decrease in tissue O(2) supply induced by severe chronic anemia increased the arterial blood L/P, specifically, with only random accompanying changes in the lactate or pyruvate concentrations themselves.When systemic O(2) consumption was increased acutely by muscular exercise, cardiac output increased, and the changes in blood L/P were small and not consistent between different dogs. But when O(2) supply to the tissues was simultaneously limited by anemia, L/P increased during exercise, and the magnitude of the increase was proportional to the severity of the anemia. These results suggest that changes in blood L/P during exercise are related specifically to tissue O(2) supply.