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Background: Several inflammatory biomarkers are implicated in the pathogenesis of periodontitis including interleukin-1β (IL-1β) and C-reactive protein (CRP). This study investigated the presence of these factors in gingival crevicular fluid (GCF) and their relationship to clinical and social determinants of periodontitis in the Australian population.
Methods: Equal numbers of periodontitis cases and non-cases were sampled during oral epidemiologic examination in the National Survey of Adult Oral Health. GCF was sampled from four sites where probing pocket depth (PPD) and recession were recorded. From these, IL-1β and CRP were quantified by ELISA and the log amount of GCF IL-1β (pg) per person and the proportion of adults with detectable CRP was computed.
Results: Periodontitis cases (n = 511) had significantly higher levels of IL-1β and CRP than non-cases (n = 562). PPD, clinical attachment loss, plaque and gingivitis indices were positively associated with elevated levels of both biomarkers. Levels of both were positively associated with age, low socio-economic position and non-Australian birth.
Conclusions: The presence of IL-1β and CRP in GCF are associated with periodontal disease parameters within the Australian population. The levels of both biomarkers are influenced by age, education and eligibility for public dental care. 相似文献
Methods: Equal numbers of periodontitis cases and non-cases were sampled during oral epidemiologic examination in the National Survey of Adult Oral Health. GCF was sampled from four sites where probing pocket depth (PPD) and recession were recorded. From these, IL-1β and CRP were quantified by ELISA and the log amount of GCF IL-1β (pg) per person and the proportion of adults with detectable CRP was computed.
Results: Periodontitis cases (n = 511) had significantly higher levels of IL-1β and CRP than non-cases (n = 562). PPD, clinical attachment loss, plaque and gingivitis indices were positively associated with elevated levels of both biomarkers. Levels of both were positively associated with age, low socio-economic position and non-Australian birth.
Conclusions: The presence of IL-1β and CRP in GCF are associated with periodontal disease parameters within the Australian population. The levels of both biomarkers are influenced by age, education and eligibility for public dental care. 相似文献
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Liver hemangioma: US-guided 18-gauge core-needle biopsy 总被引:6,自引:0,他引:6
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Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats 总被引:4,自引:2,他引:2
Herman AE; Galaburda AM; Fitch RH; Carter AR; Rosen GD 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(5):453-464
Induction of microgyria by freezing injury to the developing somatosensory
cortex of neonatal rats causes a defect in fast auditory processing in
males, but not in females. It was speculated that early damage to the
cortex has sexually dimorphic cascading effects on other brain regions
mediating auditory processing, which can lead to the observed behavioral
deficits. In the current series of experiments, bilateral microgyri were
induced by placement of a freezing probe on the skulls of newborn male and
female rats, and these animals were tested in adulthood for auditory
temporal processing. Control animals received sham surgery. The brains from
these animals were embedded in celloidin, cut in the coronal plane and the
following morphometric measures assessed: microgyric volume, medial
geniculate nucleus (MGN) volume, cell number, and cell size, and, as a
control, dorsal lateral geniculate nucleus (dLGN) volume, cell number and
cell size. There were no sex differences in the cortical pathology of
lesioned animals. However, microgyric males had more small and fewer large
neurons in the MGN than their sham-operated counterparts, whereas there was
no difference between lesioned and sham-operated females. There was no
effect on dLGN cell size distribution in either sex. Microgyric males were
significantly impaired in fast auditory temporal processing when compared
to control males, whereas lesioned females exhibited no behavioral
deficits. These results suggest that early injury to the cerebral cortex
may have different effects on specific thalamic nuclei in males and
females, with corresponding differences in behavioral effects.
相似文献
109.
The purpose of this study was to evaluate the gait responses of individuals with low vision compared to those of normal-visioned individuals when their vision is challenged by extreme levels of light. Twenty subjects with age-related maculopathy (ARM) and 20 subjects with normal vision first walked along a flat, unobstructed path immediately after the ambient light level was changed from low (5 lux) to high (2500 lux). The procedure was repeated after the light was reduced from the high to the low level. Muscle activity, temporal and kinematic variables, and ground reaction forces were used to detect gait characteristics because of ambient light level changes. Data suggested that ARM subjects walked slower and with more caution than normal subjects but that these differences were not related to ambient light level. Head angle, an estimate of gaze direction, was lower for ARM subjects during high light, but the gaze direction for both groups was low during low light. Among these ARM subjects, extreme levels of ambient light did not affect gait; subjects made adaptations that were reasonable to encourage safe ambulation, despite the direction of light change. Normal-visioned individuals in this study experienced more difficulty in low light than high light situations. 相似文献
110.
AE Kark MD FRCS JC McAlpine MB FRCPath 《International journal of clinical practice》1994,48(4):216-217
SUMMARY A hazard associated with eating raw fish is presented. The larval nematode Anisakis marina (‘herring worm‘) is a recognised public health problem in Japan, and cases have been reported in the UK. The intestinal burrowing of the larval form causes acute abdominal symptoms clinically resembling acute appendicitis. Operation is required; no antiparasitic agent is available. 相似文献