首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3502408篇
  免费   256356篇
  国内免费   6799篇
耳鼻咽喉   47719篇
儿科学   114325篇
妇产科学   95418篇
基础医学   506197篇
口腔科学   99608篇
临床医学   318596篇
内科学   676434篇
皮肤病学   78203篇
神经病学   277663篇
特种医学   131194篇
外国民族医学   710篇
外科学   526086篇
综合类   77411篇
现状与发展   14篇
一般理论   1287篇
预防医学   270915篇
眼科学   83572篇
药学   259306篇
  15篇
中国医学   7960篇
肿瘤学   192930篇
  2021年   28177篇
  2019年   28886篇
  2018年   40345篇
  2017年   30525篇
  2016年   34074篇
  2015年   38497篇
  2014年   54119篇
  2013年   80643篇
  2012年   111125篇
  2011年   117734篇
  2010年   70417篇
  2009年   65947篇
  2008年   109692篇
  2007年   116800篇
  2006年   117850篇
  2005年   113715篇
  2004年   109706篇
  2003年   105238篇
  2002年   101646篇
  2001年   164564篇
  2000年   168739篇
  1999年   141488篇
  1998年   40511篇
  1997年   35345篇
  1996年   35469篇
  1995年   33652篇
  1994年   30926篇
  1993年   28909篇
  1992年   108938篇
  1991年   105924篇
  1990年   102527篇
  1989年   98987篇
  1988年   90725篇
  1987年   88801篇
  1986年   83581篇
  1985年   79955篇
  1984年   59368篇
  1983年   50630篇
  1982年   29601篇
  1979年   53989篇
  1978年   38062篇
  1977年   31980篇
  1976年   30324篇
  1975年   32301篇
  1974年   39111篇
  1973年   37433篇
  1972年   34944篇
  1971年   32860篇
  1970年   30466篇
  1969年   28827篇
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
61.
62.
We report two British cases of liver abscess, due to Klebsiella pneumoniae and associated with synchronous infection elsewhere, which required liver resection for definitive treatment. They illustrate the geographic spread of aggressive K pneumoniae liver infection and demonstrate the importance of early aggressive treatment.  相似文献   
63.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations.  相似文献   
64.
65.
66.
Henna, derived from a combination of natural leaves and coloring additives, is a common decorative dye traditionally used in many Islamic religious celebrations. Para‐phenylenediamine (PPD), a major component of black henna tattoo, is a strong sensitizer and common allergen. We report a case of severe connubial allergic contact dermatitis after black henna heterotransfer in a girl.  相似文献   
67.
68.
Owing to the frequent incidence of blast-induced traumatic brain injury (bTBI) in recent military conflicts, there is an urgent need to develop effective therapies for bTBI-related pathologies. Blood-brain barrier (BBB) breakdown has been reported to occur after primary blast exposure, making restoration of BBB function and integrity a promising therapeutic target. We tested the hypothesis that treatment with dexamethasone (DEX) after primary blast injury potentiates recovery of an in vitro BBB model consisting of mouse brain endothelial cells (bEnd.3). DEX treatment resulted in complete recovery of transendothelial electrical resistance and hydraulic conductivity 1 day after injury, compared with 3 days for vehicle-treated injured cultures. Administration of RU486 (mifepristone) inhibited effects of DEX, confirming that barrier restoration was mediated by glucocorticoid receptor signaling. Potentiated recovery with DEX treatment was accompanied by stronger zonula occludens (ZO)-1 tight junction immunostaining and expression, suggesting that increased ZO-1 expression was a structural correlate to BBB recovery after blast. Interestingly, augmented ZO-1 protein expression was associated with specific upregulation of the α+ isoform but not the α isoform. This is the first study to provide a mechanistic basis for potentiated functional recovery of an in vitro BBB model because of glucocorticoid treatment after primary blast injury.  相似文献   
69.
70.
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (Pacnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to antimicrobial‐resistant P. acnes and staphylococci strains becoming one of the main health issues worldwide. This is an update on the current topical acne treatments available in Europe, their mechanism of action, their potential to induce antimicrobial resistance and their clinical efficacy and safety.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号