SODIUM AND POTASSIUM LEVELS IN HYPERTENSIVE CHILDREN

In a baseline survey of 4,936 school children aged 6-16 years, 199 children with systolic blood pressure (SBP) values equal or greater than the 95-th percentiles for age and sex were chosen as the hypertensive group (HBP), and were matched for age and sex with 197 children with SBP from the 5-th through the 50-th percentiles as the control (normotensive) group (NBP). For both groups the intra-RBC and plasma sodium and potassium contents, 8-hour night urinary sodium, potassium and creatinine excretions for three days, and an oral saline-water load test were performed. The results show that (1) intra-RBC potassium level in the HBP was lower than that in NBP. The level in those with positive hypertension family history (FH+) was lower than that with negatives (FH-). The intra-RBC potassium contents correlated inversely with diastolic BP. No correlation between intra-RBC sodium and BP was found; (2) Plasma sodium concentration in HBP was much lower than that in NBP. No difference was found between the FH+ and FH- in the plasma sodium concentrations; (3) Mean 8-hour night urinary potassium excretion expressed as mmol/g creatinine, was lower in HBP than in NBP; (4) After the saline load test the 4-hour urinary sodium excretion was significantly higher in HBP. Of those children with FH- the 4-hour sodium excretion in HBP was higher than that in NBP, but no significant difference was found between HBP and NBP of the FH+ children in the 4-hour urinary sodium excretions.(ABSTRACT TRUNCATED AT 250 WORDS)     

改良CHOP方案治疗老年非霍奇金淋巴瘤68例临床分析

应用改良CHOP方案（环磷酰胺0．6－0．8g,iv，第1，8d，长春地辛mg,iv，第1，8d，表阿霉素60－80mg,iv，第1，8d，强的松40－80mg,po，第1－14d)，治疗老年非霍奇金淋巴瘤68例，完全缓解48例，部分缓解9例，无效11例，总有效率83．8％，3年经54．3％。因此，良CHOP方案治疗老年非霍奇金淋巴瘤效果满意。     

血管紧张素-(1-7)对心肌肥厚大鼠体外心脏缺血再灌注损伤的影响

目的探讨血管紧张素-(1-7)对心肌肥厚大鼠体外心脏缺血再灌注损伤的影响。方法通过腹主动脉结扎制作大鼠心肌肥厚模型,并用Langendorff装置建立心肌肥厚大鼠体外心脏缺血再灌注模型,观察血管紧张素-(1-7)对心肌肥厚大鼠体外缺血再灌注心脏左心室收缩压、冠状动脉流量、肌酸磷酸激酶和乳酸脱氢酶释放、心肌梗死范围的影响。结果与缺血再灌注对照组相比,血管紧张素-(1-7)处理组心脏左心室收缩压、冠状动脉流量显著提高,冠状动脉循环流出液中肌酸磷酸激酶、乳酸脱氢酶含量降低,心肌梗死范围减小。血管紧张素-(1-7)受体拮抗剂A779能够消除血管紧张素-(1-7)的这种心脏保护作用。结论血管紧张素-(1-7)能够减轻心肌肥厚大鼠体外心脏缺血再灌注损伤,其作用通过其特异性受体介导。     

Effects of Anti-CD59 on Complement- induced Platelet Activation in Adult Males with Coronary Heart Disease

INTRoDUCTIoN The abnormal activation of platelet takes Dart in the process of coronary heart disease.Besides improv.ing artery arteriosclerosis,the activation of platelet plays an important role in acute coronary syndrome,ischemic and reperfusion injury and restenosis after coronary artery angioplasty.Many studies indicate that active complement components can induce platelet ac。tivation.And some pathophysiologic changes andtreatments in CHD,such as the injury of endothelial cell,myocar…     

双重内皮素受体拮抗剂在治疗肺动脉高压中的作用

肺动脉高压（pulmonary arterial hypertension,PAH）是指在海平面静息状态下,平均肺动脉压≥25 mm Hg（1 mm Hg=0.133 kPa）,且肺毛细血管楔压≤15 mm Hg的疾病状态。PAH通常为进展性,是严重危害人们健康与生命的疾病。各研究报道PAH发病率的差异很大。     

非手术疗法治疗眼部汽枪子弹伤

眼部汽枪子弹伤多数造成眼内严重损害,但亦有部分由于子弹未进入眼内经眼球与眶壁间隙进入眼眶后,只引起眼球震荡而影响视力,经治疗后可保留一定视力.现就我院治疗病例报告如下:何××,男,9岁,住院号:18150.因汽枪弹伤伴视力下降4小时于1994年8月31日收入院.入院检查:右眼视力0.6,右上睑中央可见直径5mm贯通创口.上方球结膜下大片出血,局部隆起,可见球结膜创口.前房积血约2/3,瞳孔遮盖1/2,瞳孔直径为4×4mm,光反射迟钝.内眼未能窥清.X线眼眶正侧位片,示“右眼眶上后段异物”,即行右眼球伤口探查术,术中除见睑皮肤及结膜贯通创口外,巩膜未见创口,经清创缝合后送回病房.术后第1天检查发现右上睑下垂,玻璃体积血减少,视网膜轻度水肿,多处大片出血灶,黄斑区亦被出血遮盖.静脉滴注先锋霉素Ⅵ、血栓通及胞二磷胆碱;肌肉注射维生素B_1、B_(12);口服云南白药、维生素及能量合剂等;配合碘离子导入理疗.作角膜缘缝环X线定位摄片,确定异物在右眼眶上后段,请神经外科、耳     

维拉帕米与ATP终止室上性心动过速的临床电生理对比观察

用维拉帕米和ＡＴＰ终止２４例室上性心动过速，比较两药的有效性、电生理效应和副作用。结果显示：虽然两药主要作用于房室结，但两药复律方式、电生理效应有差异；终止室上性心动过速两药效疗相似（Ｐ〉０．０５），ＡＴ复律快（Ｐ〈０．０５）而维拉帕米复律过过程平稳且复律后心律失常发生率低（Ｐ〈０．０５）。     

社区干预对综合性轻度认知功能障碍空巢老人的影响

目的 观察农村社区干预对轻度认知功能障碍(MCI)空巢老人的影响.方法 将92例的农村空巢老人随机分成对照组和实验组,对照组实施一般措施,试验组在一般措施基础上给予综合性社区干预.干预前后采用MoCA、自我效能感量表对两组患者进行效果评价.结果 实验组MoCA得分明显高于对照组(P＜0.01),自我效能感得分明显低于对照组(P＜0.05).结论 对MCI的农村空巢老人实施社区干预可以改善患者认知状态和自我效能感.     

踝-臂指数和C-反应蛋白与高血压病下肢无症状缺血的相关性

目的踝-臂指数(ankle-brachialindex,ABI)是一种非创伤性探测下肢动脉系统有无狭窄,无症状缺血的方法。本研究通过应用ABI判断高血压下肢无症状缺血的发生率,及其与炎症的关系。方法选择连续24个月住院患者300例,其中高血压组220例,正常血压组80例,所有患者均接受下肢超声多普勒听诊仪检查,ABI小于1.0作为判断高血压下肢无症状缺血的指标,血浆C-反应蛋白(CRP)水平作为炎症反应的指标。结果220例高血压患者中有80例ABI小于1.0,占高血压患者组36.3%;正常血压组有7例ABI小于1.0,占本组8.8%,两组ABI值分别为(0.89±0.05)和(1.30±0.07)(P<0.01);高血压组中ABI<1.0与ABI>1.0的血浆CRP水平分别为(3890±1282)μg/L和(3180±1898)μg/L(P<0.01)。结论高血压组中ABI小于1.0的患者提示有下肢无症状缺血的存在,ABI小于1.0的患者血浆CRP水平升高,ABI下降、CRP水平增高与下肢无症状缺血的发生显著相关,提示炎症参与了下肢无症状缺血的发生,ABI可作为高血压患者动脉粥样硬化发生的早期指标。