改良显微小梁切除术治疗葡萄膜炎继发性青光眼

Objective To investigate the effect of trabeculectomy combined with segmental iridectomy, mitomycin C (MMC) and viscoelastic agents usage on the treatment of glaucoma secondary in uveitis. Methods According to the age, degree of inflammation and the condition of Tenon capsule of patients, differ-ent concentration of MMC (0.25-0.33 mg/ml) was used during the operation, with separation of the anterior and posterior synechia, resection of pupillary organization membrane using viscoelastic agents. Segmental iridec-tomy and releasable sutures were also performed on the patients. The visual acuity of preoperation and postoper-ation, intraocular pressure, inflammation and the complication were record. Results Forty-two eyes of 38 cases with glaucoma secondary in uveitis were studied, the mean follow-up time was (12.01±3.56) months. The postoperative visual acuity improved in 14 eyes, didn't change in 28 eyes. The postoperative inflammation of anterior chamber disappeared in 35 eyes, relieved in 7 eyes. And the average postoperative intraocular pres-sure (15.20± 4.64) mmHg was significantly lower than the preoperative intraocular pressure (38.37±12.93) mmHg (t = 8.255, P = 0.000). The total success rate was 92.9%. There were no severe complication. Conclusion Trabeculeetomy combined with MMC, viscoelastic agents usage, separation of anterior and poste-rior syneehia, segmental iridectomy and releasable suture could increase the success rate of operation on pa tients with glaucoma secondary in uveitis, decrease the complication and inflammation reaction of operation, and the recurrence of uveitis.     

改良显微小梁切除术治疗葡萄膜炎继发性青光眼

Objective To investigate the effect of trabeculectomy combined with segmental iridectomy, mitomycin C (MMC) and viscoelastic agents usage on the treatment of glaucoma secondary in uveitis. Methods According to the age, degree of inflammation and the condition of Tenon capsule of patients, differ-ent concentration of MMC (0.25-0.33 mg/ml) was used during the operation, with separation of the anterior and posterior synechia, resection of pupillary organization membrane using viscoelastic agents. Segmental iridec-tomy and releasable sutures were also performed on the patients. The visual acuity of preoperation and postoper-ation, intraocular pressure, inflammation and the complication were record. Results Forty-two eyes of 38 cases with glaucoma secondary in uveitis were studied, the mean follow-up time was (12.01±3.56) months. The postoperative visual acuity improved in 14 eyes, didn't change in 28 eyes. The postoperative inflammation of anterior chamber disappeared in 35 eyes, relieved in 7 eyes. And the average postoperative intraocular pres-sure (15.20± 4.64) mmHg was significantly lower than the preoperative intraocular pressure (38.37±12.93) mmHg (t = 8.255, P = 0.000). The total success rate was 92.9%. There were no severe complication. Conclusion Trabeculeetomy combined with MMC, viscoelastic agents usage, separation of anterior and poste-rior syneehia, segmental iridectomy and releasable suture could increase the success rate of operation on pa tients with glaucoma secondary in uveitis, decrease the complication and inflammation reaction of operation, and the recurrence of uveitis.     

SARS流行期间武汉地区一线医护人员心理调查

目的　对严重急性呼吸道综合征 (SARS)流行期间武汉地区战斗在SARS一线的医护人员心理状况进行调查 ,以便能给予更有效的心理及社会干预。方法　随机抽取武汉地区 486名工作在SARS一线的医护人员 ,采用标准的焦虑自评量表 (SAS)、抑郁自评量表 (SDS)、以及社会支持评定量表 (SSRS)进行自评问卷调查 ,数据结果采用SPSS10 .0软件进行统计学分析。结果　武汉地区SARS一线的医护人员SAS及SDS评分与中国常模比较 ,差别无显著性 (P >0 .0 5 )。但医护人员不同性别之间的SAS、SDS、及SSPS评分的统计学分析却有显著性差异 (P <0 .0 1)。并且SAS及SDS的评分与SSPS的评分有高度的负相关性 (P <0 .0 1)。结论　SARS流行期间 ,武汉地区SARS一线的医护人员总体上无明显的焦虑及抑郁心理情绪 ,但女性医护人员较男性在心理变化上可能更易产生焦虑及抑郁情绪的倾向 ,而且与其社会支持程度有一定的相关性 ,因此应当重点给予女性医护人员适当的心理干预及社会干预。     

日本血吸虫童虫培养细胞形态的初步观察

首次报道日本血吸虫童虫培养细胞的光镜及扫描电镜观察结果。光镜下日本血吸虫童虫培养细胞可分为圆颗粒形，鞭毛形、多角形、三角扇形及不规则形，其中以圆颗粒形细胞占多数。童虫培养细胞虽较成虫培养细胞小，但在光镜和扫描电镜下两者的结构相似。ＳＥＭＩＰＳ图像分析结果表明，圆颗粒形细胞和鞭毛形细胞在面积、周长、最大、最小直径及圆球率等方面差异存在显著性（Ｐ＜０．０１）。     

日本血吸虫未成熟虫卵可溶性抗原54kD等抗原保护力的鉴定

用ＳＤＳ－ＰＡＧＥ制得的日本血吸虫未成熟虫卵可溶性抗原ＳＩＥＡ ５４ＫＤ抗原免疫小鼠,用尾蚴击感染后,其肝内的总虫卵成熟卵的比例与对照组小鼠比较有显著的减少。ＳＩＥＡ５４ＫＤ抗原分子地的免疫有很强抗雌虫生殖和抗胚胎发育效果,因此可望作为日本血吸虫抗病疫苗修选分子。     

眼挫伤早期继发性青光眼血-房水屏障功能的动态观察

【目的】 探讨眼挫伤早期继发性青光眼患者药物治疗后血-房水屏障(BAB)功能的动态变化及其与眼压的关系? 【方法】 收集受伤时间在7 d内的闭合性眼挫伤患者61例61眼,分为高眼压组(39例39眼)和正常眼压组(22例22眼)?所有患者均予糖皮质激素和非甾体类药物治疗,眼压升高者予降眼压药物治疗?在治疗后不同时间点行激光蛋白细胞检测仪检测,对比高眼压组和正常眼压组不同时间点房水闪辉值与细胞数,分析房水闪辉值?细胞数与眼压的相关关系? 【结果】 挫伤患者眼压与房水闪辉值和房水细胞数呈正相关,相关系数分别为r = 0.529和0.590(P < 0.001)? 高眼压组初诊时房水闪辉(pc/ms)?每0.5 mm3房水细胞数,均显著高于正常眼压组(78 ± 60 vs 20 ± 16,205 ± 88 vs 50 ± 16,P < 0.001)?高眼压组初诊时眼压为(39 ± 10)mmHg,治疗后末次眼压为(19 ± 11)mmHg,较治疗前显著下降(P < 0.001);眼压恢复至正常范围者31例(79.5%),仍高于21 mmHg者8例(20.5%)?两组患者LFCM值随治疗时间延长呈下降趋势;正常眼压组治疗后约30 d房水闪辉值(5 ± 2)pc/ms和0.5 mm3细胞数(1 ± 1)恢复至正常范围;而高眼压组治疗后120 d房水闪辉值(9 ± 1)pc/ms和0.5 mm3细胞数(5 ± 3)仍高于正常人(P < 0.001)?【结论】 眼挫伤早期继发青光眼患者的血-房水屏障功能的损害较正常眼压者严重,且与损伤早期眼压升高密切相关?抗青光眼药物治疗眼压控制的有效率为79.5%?合理应用糖皮质激素和非甾体抗炎药可以促进BAB功能恢复?     

改良显微小梁切除术治疗葡萄膜炎继发性青光眼

Objective To investigate the effect of trabeculectomy combined with segmental iridectomy, mitomycin C (MMC) and viscoelastic agents usage on the treatment of glaucoma secondary in uveitis. Methods According to the age, degree of inflammation and the condition of Tenon capsule of patients, differ-ent concentration of MMC (0.25-0.33 mg/ml) was used during the operation, with separation of the anterior and posterior synechia, resection of pupillary organization membrane using viscoelastic agents. Segmental iridec-tomy and releasable sutures were also performed on the patients. The visual acuity of preoperation and postoper-ation, intraocular pressure, inflammation and the complication were record. Results Forty-two eyes of 38 cases with glaucoma secondary in uveitis were studied, the mean follow-up time was (12.01±3.56) months. The postoperative visual acuity improved in 14 eyes, didn't change in 28 eyes. The postoperative inflammation of anterior chamber disappeared in 35 eyes, relieved in 7 eyes. And the average postoperative intraocular pres-sure (15.20± 4.64) mmHg was significantly lower than the preoperative intraocular pressure (38.37±12.93) mmHg (t = 8.255, P = 0.000). The total success rate was 92.9%. There were no severe complication. Conclusion Trabeculeetomy combined with MMC, viscoelastic agents usage, separation of anterior and poste-rior syneehia, segmental iridectomy and releasable suture could increase the success rate of operation on pa tients with glaucoma secondary in uveitis, decrease the complication and inflammation reaction of operation, and the recurrence of uveitis.     

冠心病血清对氧磷酯酶1活性与氧化功能指标的研究

目的初步探讨冠心病（CHD）中血清对氧磷酯酶1（PON1）的抗氧化功能。方法测定心绞痛及心肌梗死患者血清中PON1活性,比较其与氧化指标丙二醛（MDA）、还原型谷胱甘肽（GSH）及血脂指标的相关性。结果心绞痛组及心肌梗死组患者血清PON1均低于正常对照组,且心肌梗死组低于心绞痛组。与脂质氧化产物MDA呈负相关,与抗氧化指标GSH呈正相关。结论血清PON1参与脂质抗氧化机制,可能是高密度脂蛋白胆固醇（HDL-C）抑制动脉粥样硬化的主要酶。     

急慢性肝炎患者心理健康状况比较

目的；比较急，慢性肝炎患者心理状况及其与肝功能之间的关系。方法：采用SCL－90，SAS，SDS，EPQ及社会支持量表进行问卷调查，结果输入计算机进行统计分析。结果：慢性肝炎患者阳性项目数，强迫，抑郁，恐怖，偏执及精神病性等因子分均高于急性肝炎患者（P＜0．05）。结论：慢性肝炎患者心理症状的严重程度高于急性肝炎患者，对这类患者除药物治疗餐，积极的心理和社会干扰尤为重要。     

子宫输卵管碘油造影并发肺栓塞的早期诊断

子宫输卵管碘油造影以操作简便、费用低、痛苦小、设备要求不高、安全可靠等优势，目前仍是诊断女性不孕的首选检查方法．但肺栓塞是该项检查出现的少见严重并发症，如何早期发现和预防具有重要意义。我院2002年3月～2007年3月共行子宫输卵管碘油造影530例，发现肺栓塞病例4例，均及时发现和处理成功．无后遗症。现报道如下。