脂肪肉瘤及其治疗

脂肪肉瘤是最多见的软组织肿瘤,其临床表现、病理和分子特征多种多样.手术治疗仍然是治疗的基础,是惟一提供治愈可能的方法.分子生物学的发展,相关分子通路、癌基因及抑癌基因等的发现,使靶向药物治疗脂肪肉瘤在将来变为可能.     

Expression and clinical significance of FPARγ and β-catenin in breast cancer

Objective To study the expression of peroxisome proliferator-activated receptor γ (PPARγ) and β-catenin in breast cancer, and their correlations with clinicopathological parameters and prognosis. Methods Tissue samples obtained from 70 patients with breast cancer and 20 patients with breast benign mass were immunohistochemically examined for the expression of PPARγ and p-catenin. Results Overexpression rate of PPARγ protein was 34. 3% in breast cancer, significantly lower than that in breast benign mass. Abnormal expression rate of β-catenin in breast cancer was 67. 1%. A significant negative-correlation was found between the expression of PPARγ and β-catenin (r=-0. 398,P<0.05 ). PPARγ expression was inversely associated with histologic grade, tumor size, axillary lymph node metastasis,TNM stage and Ki-67 expression (P<0. 05), while positively correlated with ER status and overall survival rate (P<0. 05). Abnormal β-catenin expression was positively associated with histologic grade, axillary lymph node metastasis and TNM stage (P<0. 05), while inversely correlated with overall survival rate (P<0.05). Conclusion PPARγ and β-catenin are correlated with development of breast carcinoma,suggesting that detection of PPARγ and β-catenin may be of value in evaluating the biological behaviors and the prognosis of breast cancer.     

慢性消化道出血的早期诊断

目的：探讨慢性消化道出血的早期诊断。方法：本组８６例,男５０例,女３６例。通过纤维内窥镜、常规小肠钡餐、小肠气钡双重造影、选择性肠系膜动脉造影（经动脉造影导管放入钢丝标记１０例）、核素扫描等单项或多项检查,最终经手术和病理确诊。结果：１７．４％病变位于上消化道,８２．６％位于下消化道。结论：引起出血的病因众多,但血管畸形占３４．９％,小肠平滑肌肿瘤占２４．４％。各科医生的密切配合,针对具体情况采取合理的检查步骤,可望对出血的部位和病因作出早期诊断。