生长抑素对奥迪括约肌运动的作用机制

目的了解徨长抑素影响败类迪括约肌运动的神经通路成分。方法建立奥迪括约股测压慢性实验动物模型,研究Ｍ受体阻断剂、α受体阻断剂、β受体阻断剂、５－ＨＴ４受体阻断剂、一氧化氮合酶抑制剂和河豚毒素对生长抑素调节奥迪括约肌运动的影响。结果阿托品、二乙胺盐酸甲酯和河豚毒素阻断生长抑素对括约肌的兴奋作用;Ｌ－精氨酸甲酯阻断生长抑素对括约肌的抑制作用。结论生长抑素通过胆碱能和５－羟色胺神经元组成的兴奋性神经通路,     

急性心肌梗塞患者QT离散度与室性心律失常分级的关系及其 …

回顾性单盲法分析１０６例急性心肌梗塞患者入院后首次心电图,参照室律失常Ｌｏｗｎ和Ｗｏｆｆ分级分组,观察ＱＴ离散度与室性心律失常恶性程度的关系,探讨ＱＴｄ对ＡＭＩ患者预后的预测价值。认为ＱＴｄ值检测,对ＡＭＩ预后的预测具有一定的临床意义。     

急性心肌梗塞患者QT离散度与室性心律失常分级的关系及其临床意义

回顾性单盲法分析 10 6例急性心肌梗塞 (AMI)患者入院后首次心电图 ,参照室性心律失常Lown和Woff分级分组 ,观察QT离散度 (QTd)与室性心律失常恶性程度的关系 ,探讨QTd对AMI患者预后的预测价值。结果显示 ,QTd在AMI患者各亚组间和AMI组与正常对照组间差异均具有高度显著性 (P均 <0 0 1) ,且AMI组QTd与所发的室性心律失常恶性程度呈正相关 (rs’ =0 .5 73)。认为QTd值检测 ,对AMI预后的预测具有一定的临床意义     

Efficacy and Mechanism of Intravenous Sotalol for Termination of Paroxysmal Supraventricular Tachycardia

ＳＶＴ ,ｉｎｃｌｕｄｉｎｇＡＶＲＴａｎｄＡＶＮＲＴ ,ｉｓａｋｉｎｄｏｆａｒｒｈｙｔｈｍｉａｏｆｔｅｎｓｅｅｎｉｎｃｌｉｎｉｃａｌｐｒａｃ ｔｉｃｅ .Ｓｏｔａｌｏｌ,ａｃｌａｓｓⅢａｎｔｉ ａｒｒｈｙｔｈｍｉｃｄｒｕｇｗｉｔｈａｄｄｉｔｉｏｎａｌβ ｂｌｏｃｋｉｎｇａｇｅｎｔｐｒｏｐｅｒｔｉｅｓ ,ｈａｓｂｅｅｎｗｉｄｅｌｙｕｓｅｄｔｏｔｒｅａｔｖａｒｉｏｕｓａｒｒｈｙｔｈｍｉａ(ｓｕｐｒａ ｖｅｎｔｒｉｃｕｌａｒａｎｄｖｅｎｔｒｉｃｕｌａｒ)ｅｆｆｉｃｉｅｎｔｌｙｉｎｗｅｓｔｅｒｎｃｏｕｎｔｒｉｅｓ[1 9]…     

Retrospective Study on the Efficacy and Safety of Quinacrine Sterilization

Objective To observe and evaluate the efficacy and safety of quinacrine sterilization.Methods A total of 572 cases of quinacrine sterilization preformed during the 4 years from 1993to 1997in Jiangsu and Guizhou Provinces were employed in this study. The efficacy and safety of quinacrine sterilization in those case were studied and evaluated, with 588 cases of surgical sterilization performed at the same time being the control group.Results Both groups were with identical demographic and gynecological characteristics. The result of multiple decrement life table analysis showed the 12th gross cumulative failure rates for quinacrine sterilization was 3. 13% and serious side effects occurred in only 2 cases accounting for O. 35%. One was ectopic pregnancy (20 months after treatment). The other was due to anaphylaxis in 10 minutes after the second insertion). No difference in the liver and nephic functions was detected and no suspected cancer cells or cancer cells were found in the two groups. 99. 6% of the 572 women interviewed accepted the quinacrine sterilization.Conclusions Quinacrine sterilization method is with high acceptability but comparatively low effectiveness. It has been proved to be a safe method of contraception in short-term. However, the safety of long-term still needs further study.     

甲胎蛋白与肝癌关系新进展

甲胎蛋白(AFP)作为原发性肝癌较为敏感而特异的生化标志,在旰癌普查、早期诊断、疗效判断等方面发挥了重要作用。近几年还有不少新的思路,如AFP异质体用于肝癌的鉴别诊断等。然而,AFP基因表达的调控及其生物学活性十分复杂,其与肝癌发生发展之间的关系尚未完全阐明,某些基础研究的成果也亟待推广应用于临床。     

妊娠妇女血清CG及TBA测定的临床意义

采用放射免疫分析法和速率法分别测定正常组和孕妇组血清 Ｃ Ｇ、 Ｔ Ｂ Ａ 含量。结果表明： Ｃ Ｇ、 Ｔ Ｂ Ａ 在中、晚孕期显著高于正常对照组。其中 Ｃ Ｇ 在中期就存在显著差异（ Ｐ＜ ０ ．０５） ,至晚孕期差异极显著（ Ｐ＜ ０ ．０１） 。提示 Ｃ Ｇ 指标在判断肝、胆代谢功能的价值优于 Ｔ Ｂ Ａ。     

多普勒超声心动图评估左心室舒张末压的研究

目的探讨多普勒超声心动图评估左室舒张末压的有效方法与指标。方法对６８例病人采用左心导管测压及经胸多普勒超声心动图检测。结果对比研究显示,联合肺静脉与二尖瓣血流频谱分析优于二尖瓣血流频谱分析,肺静脉Ａ峰和二尖瓣Ａ峰时限差值（ＰＡｄ－Ａｄ）与左室舒张末压实测值呈最佳相关性（ｒ＝０．７２,Ｐ＜０．０１）。结论认为应用多普勒超声心动图测定ＰＡｄ与Ａｄ,并以其差值估测左室舒张末压,是一项简便、可靠的无创性评估左室舒张末压的方法。ＰＡｄ－Ａｄ≥０可作为临床判断左室舒张末压增高［≥２．０ｋＰａ（１５ｍｍＨｇ）］的一项半定量指标。