间断发热九个月,胸闷半个月

病例摘要 1.一般情况:患者,43岁,女性.因间断发热9个月,胸闷半个月入院.9个月前患者无明显诱因出现发热,以午后明显,最高体温可达39.5℃,偶感畏寒,伴咳嗽,阵发性连声咳,有痰,为白色黏液痰,不易咳出,无头痛头晕,无胸闷胸痛、无心悸气短、无腹痛腹泻等其它不适,曾多次到当地医院就诊,具体诊断不祥,曾多次使用"头孢哌酮、氧氟沙星、林可霉素"等抗感染治疗,症状可缓解.     

蛋白激酶蛋白家族的功能研究进展

蛋白激酶D(protein kinase D,PKD)属丝氨酸/苏氨酸(serine/threonine,Ser/Thr)蛋白质家族,主要包括3个成员:PKD1/PKCμ、PKD2、PKD3/PKCν。其结构相对保守,均具有相似的调节结构域和激酶结构域。近年来的研究表明PKD家族蛋白参与细胞生长、增殖、迁移、分化、凋亡,高尔基体的组织和重建,免疫应答,内分泌调节、增强心肌收缩力等多种生理功能。     

The Expression of Hypoxia Inducible Factor 1-alpha in Lung Cancer and Its Correlation with P53 and VEGF

To investigate the expression of hypoxia inducible factor 1-alpha (HIF-1α) and its corre-lation with P53 and vascular endothelial growth factor (VEGF), immunohistochemical technique was employed to detect the protein expressions of HIF-1α, P53 and VEGF in specimens from 57 pa-tients with lung cancer. The results indicated that the total positive proportion of HIF-1α expres-sion was 63% and the HIF-1α expression was more frequent in bronchiole-alveolar carcinoma (86%) than in other lung cancer. There was a strong association of HIF-1α with VEGF and P53 pro-tein expressions. It is concluded that HIF-1α overexpression is a common event in lung cancer,which may be related to the up-regulation of the angiogenic factor VEGF and oncogene mutant P53 protein.     

胃嗜酸性肉芽肿21例报告

目的探讨胃嗜酸性肉芽肿的诊断和治疗方法。方法对２１例嗜酸性肉芽肿的临床资料进行分析。结果钡餐检查２１例,诊断胃癌７例,胃溃疡１４例。胃镜检查１２例,诊断胃癌５例,胃溃疡７例。１１例外周血中嗜酸性细胞增多。４例行近全胃切除加Ｄ３淋巴结清扫,１７例胃次全切除术。１２例随诊５～１５年,９例健在。结论胃镜活检及术中快速病检可确诊,胃大部切除术是主要的治疗方法     

间断咳嗽、咯血四年，气喘三年，加重二十天

患者31岁,女性.因间断咳嗽、咯血4年,气喘3年,加重20天人院.4年前患者无明显诱因出现咳嗽,为阵发性连声咳,有痰,为白色黏痰,偶见痰中带血,为鲜红色,量不多,每次约数口,无发热、无胸闷胸痛、无心悸气短、无腹痛腹泻.