综合ICU患者死亡相关因素分析

分析进入ICU患者死亡相关因素分析，91例死因：①中枢性呼吸循环衰竭；②休克；③多系流器官功能衰竭；④猝死     

嗜酸性粒细胞白血病1例

！合音，男，38岁，1990年4月初，无明显诱因出现乏力、食欲减低，当地按“胃病’”治疗无效。10天后出现发热、咳嗽、胸疼、盗汗而就诊。化验发现白细胞总数年，哈酸性粒细胞平。狗进肺纹理稍高，拟诊为“肺嗜酸性粒细胞增多症”，给予青霉素、筑美松、肠虫清治疗3天。上述症状加密，并出现心慌、气短，于1990年4用地回收入院。查体：＊3乙6C，卜96匕。。；l、R25沉／。l。。BP16／llka，中年男性，神忐清，精神叮。轻度贫血貌，全身皮肤粘膜无出血及黄染，左足背皮下有三．3X3cm不规则无疼性肿块，全身浅表淋巴结米价及肿大，胸骨中下段…     

Effects of ranitidine on contraction and action potentials in normal and potassium depolarized isolated papillary muscles of the guinea pig

The purpose of these experiments was to investigate the possible ionicbases for ranitidine (Ran) in isolated papillary muscles of the guinea pig.Ran,when the concentration was below 300μmol/L,had no influence on contraction ofnormal muscles and only above 0.3 mmol/L,it showed weak negative inotropic ef-fect.The contractile activity elicited by histamine in potassium depolarized mus-cles was depressed by Ran markedly and dose-dependently.The IC_(50) of Ran was0.273μmol/L.This depressant effect was reversed by an elevation of externalCa~(2+)concentration to 7.7mmol/L.The contraction induced by isoproterenol inpotassium depolarized preparations was not altered by Ran.Ran at theconcentrations of 1,10 and 100μmol/L failed to show influences on fast actionpotentials.However,Ran at 0.5μmol/L time-dependently inhibited slow action po-tentials.It is concluded that the ionic mechanism of Ran might be attributed toantagonized H_2 receptor of myocardium which in turn decreases Ca~(2+) inward cur-rent.     

18例后腹腔镜下肾囊肿去顶减压术的手术配合

探讨后腹腔镜下肾囊肿去顶减压术的术中配合要点,手术室护士需要做好充分的术前准备工作,熟知手术步骤,熟练掌握手术仪器的性能及使用方法.     

Aqueous Extracts of Tribulus terrestris Protects Against Oxidized Low-Density Lipoprotein-Induced Endothelial Dysfunction

Objective:To investigate the role of aqueous extracts of Tribulus terrestris(TT) against oxidized low-density lipoprotein(ox-LDL)-induced human umbilical vein endothelial cells(HUVECs) dysfunction in vitro.Methods:HUVECs were pre-incubated for 60 min with TT(30 and 3 μg/mL respectively) or 10~(-5) mol/L valsartan(as positive controls) and then the injured endothelium model was established by applying 100 μg/mL ox-LDL for 24 h.Cell viability of HUVECs was observed by real-time cell electronic sensing assay and apoptosis rate by Annexin V/PI staining.The cell migration assay was performed with a transwell insert system.Cytoskeleton remodeling was observed by immunofluorescence assay.The content of endothelial nitric oxide synthase(eNOS) was measured by enzyme-linked immunosorbent assay.Intracellular reactive oxygen species(ROS) generation was assessed by immunofluorescence and flow cytometer.Key genes associated with the metabolism of ox-LDL were chosen for quantitative real-time polymerase chain reaction to explore the possible mechanism of TT against oxidized LDL-induced endothelial dysfunction.Results:TT suppressed ox-LDL-induced HUVEC proliferation and apoptosis rates significantly(41.1%and 43.5%after treatment for 3 and 38 h,respectively;P0.05).It also prolonged the HUVEC survival time and postponed the cell's decaying stage(from the 69 th h to over 100 h).According to the immunofluorescence and transwell insert system assay,TT improved the endothelial cytoskeletal network,and vinculin expression and increased cell migration.Additionally,TT regulated of the synthesis of endothelial nitric oxide synthase and generation of intracellular reactive oxygen species(P0.05).Both 30 and 3 μg/mL TT demonstrated similar efficacy to valsartan.TT normalized the increased mRNA expression of PI3Kα and Socs3.It also decreased mRNA expression of Akt1,AMPKα1,JAK2,LepR and STAT3 induced by ox-LDL.The most notable changes were JAK2,LepR,PI3 K α,Socs3 and STAT3.Conclusions:TT demonstrated potential lowering lipid benefits,anti-hypertension and endothelial protective effects.It also suggested that the JAK2/STAT3 and/or PI3K/AKT pathway might be a very important pathway which was involved in the pharmacological mechanism of TT as the vascular protective agent.     

不同类型茶叶对小白鼠体质量的影响

目的：探讨不同类型茶叶对体质量的控制作用,探讨茶叶对肥胖的预防保健作用。方法：将42只体质量超过普通饲料喂养小鼠体质量20％的小鼠做为单纯肥胖模型,随机分为4组,分别为空白对照组12只,红茶喂养组、绿茶喂养组和黑茶喂养组,每组10只,共喂养45 d。实验前后观察小鼠体质量。结果：喂养45 d后,空白对照组小鼠体质量增加了37.49 g,而红茶、绿茶、黑茶组分别增加32.87、33.08、32?53 g,较空白对照组分别减少12.3％、11.7％、13.2％( P<0.05)。结论：长期坚持喂养茶叶可有效地控制生长期小鼠体质量的增长。相对而言,黑茶的效果显著,红茶次之。     

先天性阑尾缺失一例报告

<正> 阑尾是退化性器官,但先天性阑尾缺失比较少见,现将我们在尸体解剖中所见一例报告如下: 死者成年、男性,身长158厘米,体质营养较差。发黑无斑秃,头、颈、躯干、外生殖器、及眼、耳、鼻、口等均无畸形。胸腹部未见疤痕,四肢除左髋关节拟为结核性关节炎伴病理性后脱位外,其他皆无特殊。全部暴露胸腔,腹腔和盆腔后:见胸腔内除胸膜有轻微粘连外,其他无异常。腹腔和盆腔内腹膜无粘连,无明显积液,肝、胆、胰、胃、脾、肾及小肠皆未见有特别。大肠未现炎症现象,盲肠位于右髂凹内,可以游离,其末端阑尾缺失。盆腔脏器正常。仔细检查全部大肠未见     

暖贴巾对实验动物皮肤毒理学研究

目的 观察暖贴巾对实验动物皮肤的毒性作用．方法 用暖贴巾分别对豚鼠完整皮肤与破损皮肤进行急性毒性试验、家兔完整皮肤与破损皮肤进行刺激试验、豚鼠皮肤进行过敏试验。结果 暖贴巾对豚鼠完整皮肤与破损皮肤无急性毒性反应，对家兔完整皮肤与破损皮肤无刺激反应，对豚鼠皮肤无过敏反应。结论 暖贴巾对实验动物皮肤未见毒性、刺激性和过敏性反应，说明其毒性极低，为临床使用提供了一定的安全依据。     

停用宫内节育器后再生育人群生育结局双向性队列研究

目的探讨停用避孕措施后再生育人群不良妊娠结局的发生情况。方法采取双向性队列研究方法,对2014年1月—2015年12月参加江苏省溧阳市、泰兴市、沛县3个县级妇幼保健计划生育服务机构的孕前优生健康检查家庭进行筛选,以计划生育二孩的2 435人为研究对象,将末次避孕措施为宫内节育器(IUD)定义为研究组,避孕套为对照组,随访比较2组队列妊娠结局的发生情况。采用多因素logistic回归模型进行统计分析。结果本研究共纳入2 435名研究对象,其中研究组1 252人,对照组1 183人。发生不良妊娠结局273例,发生率为11.21%。其中研究组和对照组不良妊娠结局分别为141例和132例,发生率分别为11.26%和11.16%,差异无统计学意义(P=0.935),调整人群基本特征、月经问题、女性生殖系统方面特征以及子女健康状况等混杂因素后,IUD组不良妊娠结局的发生风险是避孕套组的1.06倍(95%CI=0.81～1.39),差异仍无统计学意义。结论使用IUD未增加不良妊娠结局的风险。     

小儿导水管阻塞性脑积水32例治疗体会

目的　评价脑室一腹腔分流术（ＶＰＳ）对小儿导水管阻塞性脑积水的疗效。方法　回顾性总结了３２ 例小儿导水管阻塞性脑积水的临床表现、诊断、治疗与疗效。结果　３２ 例中恢复良好１４ 例,好转１２ 例,有效６ 例。结论　采用ＶＰＳ治疗小儿导水管阻塞性脑积水是一种安全有效的治疗方法。