慢性肾脏疾病免疫状态的初步观察(附118例分析)

近十多年来,随着免疫学及免疫技术的迅速发展,证实各种肾脏疾病的发病与细胞免疫、体液免疫及补体等有密切关系。我院自1980年3月以来,对118例各种慢性肾脏疾病患者的免疫状态进行了初步观察,现将结果报告如下:     

AMNIOTIC FLUID FETAL BLOOD GROUP PREDICTION AND USE lN NEWBORN HEMOLYTIC DISEASES

In this article the method for testing amnio- tic fluid blood group substances is described and the results of 107 determinations presented. Amniotic fluid blood group substances agree completely with those of the fetal blood. The method of determination is simple, easy to handle and requires no expensive equipment and therefore can be carried out in most laboratories. The clinical application of this determination in hemolytic diseases of the newborn due to ABO or Rh incompatibility is discussed.     

SPERMIDINE RADIOIMMUNOASSAY IN MONITOR OF PRECANCEROUS LESIONS OF ESOPHAGUS

Serum spermidine was assayed by radioimmuno-assay in different stages of esophageal carcinogenesis in the population from high risk area of esophageal cancer, Linxian County. The serum spermidine values were 76.94 74.38 ng ml in 36 normal individuals; 115.71 113.45 ng/ml in 35 patients with marked epithelial hyperplasia (MEH) and 294.48 135.36 ng/ml in 31 patients with early esophageal cancer. Patients with MEH were given intervention treatment by Aminoretinoic Ester or Anticancer B or placebo (starch) as controls. One year later, samples from the population were collected again for serum spermidine msasurement. The values were 95.8 68.2 ng/ml in 27 normals; 125.1±72.9 ng/ml in 62 patients with MEH treated by Anticancer B; 125.6± 117.2 ng/ml in 64 patients with MEH treated by Aminoretinoic Ester; 162.4±76.6 ng/ml in 62 controls and 210.5±182.9 ng/ml in 44 patients with early esophageal cancer.The results showed that spermidine radioim-munoassay could reflect the tendency of esophageal precancerous     

雷公藤治疗肾小球肾炎84例临床分析

本文报告以雷公藤为主,分别合用利尿,降压、抗感染药或激素、细胞毒药物,治疗各型肾小球肾炎84例,总有效率71.4%,近期缓解率39.3%。肾小球肾病、急性肾炎、慢性肾炎普通型及隐匿性肾炎的疗效显著。对比单用雷公藤治疗53例的疗效结果,差异无显著性。为提高雷公藤的临床疗效,坚持以雷公藤为主的中西医结合治疗方法,值得进一步的研讨。     

神经干和脐带间充质干细胞联合应用对神经系统疾病后遗症状改善的疗效观察

目的观察神经干细胞联合脐带间充质干细胞治疗神经系统疾病后遗症状的改善疗效。方法选取2009至2012年神经内科接受治疗的患者31例,包括脑卒中患者24例(脑出血15例、脑梗死9例)、共济失调患者7例,31例患者均进行神经干细胞联合脐带间充质干细胞移植治疗。脑卒中治疗后后遗症状的改善情况采用欧洲卒中评分、生活功能评分进行评估,共济失调患者治疗后的后遗症状的改善情况采用世界合作共济失调量表进行评估,并观察31例患者在治疗过程中的不良发应。结果脑卒中治疗后其欧洲卒中评分及生活功能评分较治疗前显著提高(P<0.05),而共济失调患者的较治疗前世界合作共济失调量表的评分显著下降(P<0.05),不良反应为术后头疼(5例,脑卒中组),短暂低温(4例,共济失调组),经对症治疗后显著好转。结论神经干和脐带间充质干细胞联合移植治疗能在短期内(6个月)有效改善神经系统疾病患者的后遗症,长期疗效有待进一步观察。     

亚甲基四氢叶酸还原酶基因多态和叶酸摄取与乳腺癌的发病风险

Objective To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk. Methods A case-control study was conducted with 669 cases and 682 population-based controls in Jiangsu province of China. MTHFR C677T and AI298C genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Dietary folate intake was assessed by using an 83-item food frequency questionnaire. Odds ratios (OR) were estimated with an unconditional logistic model. Results The frequencies of MTHFR C677T C/C, C/T and T/T genotypes were 32. 37% (202/624), 48. 88% (3051624) and 18. 75% (117/624) in cases and 37. 66% (235/624), 48.24% (301/624) and 14. 10% (88/624) in controls,respectively. The difference in distribution was significant (X2=6. 616, P=0. 037), the T/T genotype being associated with an elevated OR for breast cancer (1.62, 95% CI: 1.14 -2. 30). The frequencies of MTHFR A1298C A/A,A/C and C/C were 71.47% (446/624), 27.08% (169/624) and 1.44% (9/624) in cases and 68. 11% (425/624) ,30. 13% (188/624) and 1.76% (11/624) in controls, with no significant differences found (X2=1.716, P=0. 424). Folate intake of cases [(263.00±137. 38)μg/d]was significantly lower than that of controls [(285. 12±149. 61)μg/d](t=-2. 830,P=0. 005). Compared with the lowest tertile (≤199. 08μg/d) of folate intake,the adjusted OR for breast cancer in the top tertile (≥315.μg/d) was 0. 70 (95% CI:0. 53 -0. 92). Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0. 89 (95% CI: 0. 62 -1.27)and 1.69 (95% CI: 1.20 -2. 36) for the second to the third tertite of folato intake compared with thehighest folate intake group (Xtrend2=11. 372, P=0. 001). Conclusion The findings of the present study suggest that MTHFR genetic polymorphisms, and dietary intake of folate may modify susceptibility to breast cancer.     

骨良性肿瘤及肿瘤样病变的CT 诊断

目的 探讨骨良性肿瘤及肿瘤样病变的ＣＴ诊断及其鉴别诊断。方法 ２９例骨良性肿瘤及肿瘤样病变均作ＣＴ扫描,并经手术和病理证实,分析其ＣＴ表现。结果 ＣＴ诊断正确率为９３．５％（２７／２９）。它易于显示病变的特征,对骨质破坏、骨膨胀、硬化缘、出血、骨间隔、钙化及软组织肿声等均能很好的显示。结论 根据ＣＴ扫描的特点及表现,大多数骨良笥肿瘤及肿瘤样病变可作为正确诊断。     

四肢、躯干部软组织恶性肿瘤的CT影像分析

软组织肿瘤的常规Ｘ线检查往往显示不清 ,这是由于常规Ｘ线检查由于密度分辨率较低 ,难以对软组织肿瘤作出正确的判断和诊断。而ＣＴ检查具有较高的密度分辨率 ,所以ＣＴ不仅可以排除或确定软组织肿瘤的存在与否 ,而且可以对一些软组织肿瘤作出良恶性的判断。同时可以为外科医生在制定手术方案时提供下述情况 :病变的范围和解剖部位 ,大血管和重要的神经是否受累 ,有包膜或者是浸润性生长。国外学者已将ＣＴ视为检查软组织肿瘤的主要影像学方法［１］ ,但国内有关这方面的报道相对较少。我们收集了本院自１９９４年９月～１９９９年７月经Ｃ…     

基层医院术中意外急救流程再造

随着现代医学的飞速发展和高新技术在外科领域的广泛应用,手术室作为患者进行外科治疗的特殊场所,工作中存在任务重、工作节奏快、抢救急危患者多等现象[1]。在手术过程中,难免会遇到各种各样的意外事件发生,如何确保手术意外时抢救成功率、减少损失从而保障手术成功,快速有效的应对是对手术室工作人员面对的重大挑战。因此,手术室对紧急情况的自如应对至关重要,近来越来越受医院管理者重点关注。