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71.
经皮椎体成形术(percutaneous vertebroplasty,PVP)因其操作简单、疼痛缓解快,已广泛用于治疗椎体压缩性骨折、多发性骨髓瘤、椎体转移性病变和血管瘤引起的疼痛。尤其在治疗骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)上取得了显著的疗效。然而,随着PVP的应用越来越多,随之而来的并发症(包括骨水泥渗漏、神经压迫、再骨折、感染以及骨水泥栓塞等)也显著增多。在这些并发症中,PVP术后椎体感染发生率低,治疗经验有限,并无统一的治疗标准,且其发生后是否需要手术以及手术方式的选择仍存在争议。2016年1月~2020年1月我院手术治疗9例PVP术后椎体感染的患者,总结如下。 相似文献
72.
73.
短暂性脑缺血频繁发作38例临床分析 总被引:1,自引:0,他引:1
短暂性脑缺血发作(TIA)是神经内科常见急症,部分患呈现短时间内反复或连续发作,即短暂性脑缺血频繁发作。作对1997-2003年诊断明确、资料完整的短暂性脑缺血频繁发作38例患进行分析,并就其临床特点、治疗及预后评价进行探讨。 相似文献
74.
目的:探讨一期前后路联合手术治疗腰椎结核的疗效及特点。方法34例符合手术指征的腰椎结核患者,进行2周以上HRZE抗结核治疗后均行一期后路固定前路病灶清除术,术后继续规范抗结核治疗并随访1~2年,观察患者症状改善情况[疼痛视觉模拟评分(VAS评分)]、腰椎畸形矫正情况(cobb角)、神经功能改善情况(frankel分级)。结果34例患者术中出血量平均900 ml,手术时间3~7 h,平均手术时间4.2 h,住院时间25~65 d,平均住院时间35 d,出院后均获得随访,时间1~2年,术后末次随访X线均显示骨性融合, VAS获得改善,26例患者Cobb角减小,31例患者frankel分级获得提高。结论对符合手术指征的患者,在系统抗结核化疗药物治疗基础上,一期后路固定前路病灶清除术可获得良好的临床效果,是目前手术治疗腰椎结核较为理想的方案。 相似文献
75.
为探讨亚急性脊髓联合变性(SCD)的早期诊断方法,我们对9例SCD的诊断方法及结果进行分析。现报告如下。 相似文献
76.
正下颈椎骨折脱位常伴有单侧或双侧关节突绞锁~([1]),如何在较短时间内以安全简单的方法使绞锁的关节突复位,是治疗下颈椎骨折脱位手术的难点之一。我们采用术中颅骨牵引结合撬拨助推技术辅助下行颈前路复位椎间融合内固定术治疗单节段下颈椎关节突绞锁患者30例,临床效果良好,总结报告如下。临床资料30例患者中,男18例,女12例;年龄18~76岁(38.5±0.3岁);交通事故伤15例,重物砸伤6 相似文献
77.
目的比较后路长节段固定联合伤椎打压植骨与联合伤椎骨水泥强化治疗Ⅲ期Kümmell病的疗效。方法采用回顾性队列研究分析2016年1月至2020年12月郑州市骨科医院收治的38例Ⅲ期Kümmell病患者临床资料, 其中男8例, 女30例;年龄59~81岁[(68.9±4.9)岁]。骨折椎体:T8 1例, T11 9例, T12 10例, L1 8例, L2 10例。17例行后路长节段固定联合伤椎椎弓根打压植骨术治疗(打压植骨组), 21例行后路长节段固定联合伤椎骨水泥强化术治疗(骨水泥组)。比较两组手术时间、术中出血量;术前、术后1周、术后3个月及末次随访时视觉模拟评分(VAS)、日本骨科学会(JOA)评分、后凸Cobb角;末次随访时骨性愈合情况;并发症发生率。结果患者均获随访24~35个月[(28.7±2.9)个月]。打压植骨组手术时间为(150.7±25.4)min, 术中出血量为(285.3±48.6)ml;骨水泥组分别为(132.0±21.1)min和(251.4±44.8)ml(P均<0.05)。术前两组VAS、JOA评分及后凸Cobb角差异无统计学意义(P均>0.0... 相似文献
78.
自体骨髓间充质干细胞移植治疗阿尔茨海默病4例 总被引:1,自引:0,他引:1
阿尔茨海默病患者10例,按治疗方法分为两组:干细胞原位治疗组6例,给予重组人粒细胞集落刺激因子150μg,腹部皮下注射,1次/d,7~10d为1个疗程;同时给予丹参注射液20mL,静脉滴注,1次/d,10d为1个疗程;自体骨髓干细胞治疗组4例,经骨髓穿刺采集自体骨髓230~330mL,分离提取骨髓单核细胞后经静脉途径和/或椎管内一次性或分次注射;注射后当日给予干细胞原位治疗。干细胞治疗前、治疗3个月后进行简易智能测量、日常生活活动能力评分及外周血细胞监测,并对患者神经功能变化及不良反应进行评价。干细胞原位治疗组6例患者未发现任何不良反应,外周血白细胞计数控制在(35~40)×109L-1。治疗后3个月时简易智能测量评分及日常生活活动能力评分均高于治疗前(P<0.05)。自体骨髓干细胞治疗组4例患者中发热2例,体温均在38℃以下,且24h后体温恢复正常;有轻微头痛3例,未行治疗24h后缓解。治疗后3个月时简易智能测量评分及日常生活活动能力评分均显著高于治疗前(P<0.01)。骨髓间充质干细胞移植治疗阿尔茨海默病近期疗效明显,不良反应较少,与干细胞原位治疗联合应用疗效更佳,其远期疗效还需要进一步随访和观察。 相似文献
79.
目的 观察围术期预先给予参附注射液(SF)对脑肿瘤患者术后早期康复效果的影响.方法 192例拟行择期颅内肿瘤切除手术的患者,随机分为SF组(n=95),于麻醉诱导后,用0.9%生理盐水将50mlSF稀释至200 ml并于切开硬脑膜前静脉输注完毕;对照组(n=97),于同一时间点输入0.9%生理盐水200ml.分别记录患者术毕清醒时间、拔管时间、重症监护病房停留时间、住院天数,采用Karnofsky表现评分(KPS)量表分别在术前及出院时对患者的生存质量(QQL)作出评估.结果 两组患者的苏醒时间、拔管时间及重症监护病房停留时间无明显差别(P>0.05),SF组患者住院天数为(25.3±8.8)d,少于对照组的(27.9±7.9)d (P <0.05).两组患者出院时的KPS评分均较术前明显降低(P<0.05),但两组间比较无明显差异(P>0.05).结论 在脑肿瘤手术围术期给予SF预处理能够缩短平均住院日,但对患者术后早期生存质量无明显改善. 相似文献
80.
BACKGROUND: Studies have shown that low molecular weight heparin-superoxide dismutase conjugate exhibits a remarkable neuroprotective effect.
OBJECTIVE: To investigate the effect of low molecular weight heparin-superoxide dismutase conjugate on astrocytes in an interleukin-6 (IL-6) overexpressing mice following local cerebral ischemia.
DESIGN, TIME AND SETTING: Randomized, cytological, controlled, animal study was performed in the Department of Physiology and Neuroscience, Neurology and Biochemistry and Molecular Biology, Medical University of South Carolina from January 2005 to March 2005.
MATERIALS: Nine IL-6 transgenic mice, irrespective of gender, were randomly divided into three groups: sham-operated, model, and treatment, with three mice in each group. With exception of the sham-operated group, right middle cerebral artery occlusion was induced in the mice. Expression of glial fibrillary acidic protein, an astrocyte marker, was determined by immunohistochemistry. Low molecular weight heparin-superoxide dismutase conjugate was purchased from Biochemistry and Biotechnique Institute, Shandong University.
METHODS: Two minutes prior to ischemia induction, 0.5 mL/kg saline or 20 000 U/kg low molecular weight heparin-superoxide dismutase conjugate were administrated via the femoral artery in the model group and treatment group, respectively. The sham-operated group underwent the same protocols, with the exception of occlusion and treatment.
MAIN OUTCOME MEASURES: The number of glial fibrillary acidic protein-positive cells was quantified under light microscopy (x200).
RESULTS: In the sham-operated group, there were a large number of astrocytes in the IL-6 transgenic mice. However, the cell bodies were small, and the branches were few and thin. The number of astrocytes in the model group was remarkably less than the sham-operated group. Compared to the model and sham-operated groups, the number of astrocytes significantly increased, and the cell body became larger, following treatment with low molecular weight heparin-superoxide dismutase conjugate. Astrocytes exhibited hypertrophy and hyperplasia, and the processes became longer and thicker.
CONCLUSION: The low molecular weight heparin-superoxide dismutase conjugate may provide neuroprotection through astrocytic activation at the super-early stage of cerebral ischemia and reperfusion. 相似文献
OBJECTIVE: To investigate the effect of low molecular weight heparin-superoxide dismutase conjugate on astrocytes in an interleukin-6 (IL-6) overexpressing mice following local cerebral ischemia.
DESIGN, TIME AND SETTING: Randomized, cytological, controlled, animal study was performed in the Department of Physiology and Neuroscience, Neurology and Biochemistry and Molecular Biology, Medical University of South Carolina from January 2005 to March 2005.
MATERIALS: Nine IL-6 transgenic mice, irrespective of gender, were randomly divided into three groups: sham-operated, model, and treatment, with three mice in each group. With exception of the sham-operated group, right middle cerebral artery occlusion was induced in the mice. Expression of glial fibrillary acidic protein, an astrocyte marker, was determined by immunohistochemistry. Low molecular weight heparin-superoxide dismutase conjugate was purchased from Biochemistry and Biotechnique Institute, Shandong University.
METHODS: Two minutes prior to ischemia induction, 0.5 mL/kg saline or 20 000 U/kg low molecular weight heparin-superoxide dismutase conjugate were administrated via the femoral artery in the model group and treatment group, respectively. The sham-operated group underwent the same protocols, with the exception of occlusion and treatment.
MAIN OUTCOME MEASURES: The number of glial fibrillary acidic protein-positive cells was quantified under light microscopy (x200).
RESULTS: In the sham-operated group, there were a large number of astrocytes in the IL-6 transgenic mice. However, the cell bodies were small, and the branches were few and thin. The number of astrocytes in the model group was remarkably less than the sham-operated group. Compared to the model and sham-operated groups, the number of astrocytes significantly increased, and the cell body became larger, following treatment with low molecular weight heparin-superoxide dismutase conjugate. Astrocytes exhibited hypertrophy and hyperplasia, and the processes became longer and thicker.
CONCLUSION: The low molecular weight heparin-superoxide dismutase conjugate may provide neuroprotection through astrocytic activation at the super-early stage of cerebral ischemia and reperfusion. 相似文献