Experimental and Clinical Research of Myocardial Protection Effect Using MHBC Perfusion

Objectives To determine themyocardium -protecting effect of medium hypothermalblood cardioplegia (MHBC); further demonstrates thatthe optimal temperature between these hypothermaland normothermic can overcome the disadvantages;and thus discovers a more effective myocardium pro-tecting method. Methods Section 1: 14 mongreldogs (15-20 kg) were randomly divided into twogroups: experimental group and control group; car-dialpulmonary bypass was conventionally instituted,moderate hypothermia blood cardioplegia was used inexperimental group, Blood samples from right atriumtaken for examination of lactate dehydrogenase (LDH)creatine kinase(CK-MB) and Topin Ⅰ(cTn-Ⅰ). speci-mens of left ventricular subendocardial myocardiumwere biopsied to observe changes of ultrastructure.Section 2: 24 patients were randomly divided into twogroups and both groups received two types of treat-ment (same as Section 1) after aorta cross-clamp(ACC). Biochemical index and Clinical observationwere caculated as the indicators. Results     

体外循环下肺动脉栓塞的外科治疗

目的 探讨体外循环下肺动脉切开取栓和肺动脉内膜剥脱术治疗慢性肺动脉栓塞的方法、围术期处理经验，以提高慢性肺动脉栓塞外科治疗的安全性。方法 全组12例慢性肺动脉栓塞患者均在浅低温体外循环心跳中切开肺动脉取栓及肺动脉内膜剥脱术。结果 全组12例无一例近期死亡，其中1例活检为平滑肌肉瘤，术后化疗，2年后复查元复发，其余11例均为血栓，术后临床症状减轻，活动能力明显提高。结论 体外循环下肺动脉切开取栓和内膜剥脱术是治疗慢性肺动脉栓塞的安全、有效的方法。     

体重5kg以下小婴儿心脏术后机械通气

目的　探讨新生儿、小婴儿心脏术后机械通气的管理。方法　对 15例体重 5kg以下的新生儿、小婴儿术后机械通气方式、通气参数、并发症进行回顾性分析。结果　术后机械通气时间最长 18d ,最短 3h ,平均5 3d ,机械通气过程中并发呼吸机相关肺炎 3例、肺不张 1例、术后近期死亡 4例。结论　新生儿、小婴儿心脏术后机械通气有其自身特点 ,加强术后呼吸管理 ,可降低先心病术后病死率。     

心血管手术输血后庚型肝炎病毒感染的研究

目的 研究心血管手术输血后庚型肝炎病毒（HGV）感染及其危险因素。方法 选取连续166例心血管手术患者进行前瞻性研究,检测手术前、后血样标本的庚型肝炎病毒RNA（HGV RNA）,按HGV RNA阳性和阴性分组,分析HGV感染的危险因素。结果 术后前3个月HGV总感染率4．22％。阳性组年龄大（P＜0．0217）,输血量多（P＜0．0088）,病种以非先天性心脏病为主（P＜0．0458）。结论 心血管手术输血后HGV感染率为4．22％。HGV感染与患者年龄、输血量和病种有关。提示为降低心管手术输血后HGV感染,应减少围术期输血量,并早期施行手术。     

左旋精氨酸对静脉移植保护作用的综合研究

目的:观察左旋精氨酸(L-Arg)对自体移植静脉内膜增生的影响,探讨其作用机制.方法:(1)动物实验:60只新西兰兔,随机分为左旋精氨酸实验组、生理盐水对照组.所有动物术日建立自体静脉旁路移植模型:于术后1、2、4、6周及8周取材,统计学分析各组间差异.(2)临床试验部分:将33例欲行非体外循环冠脉搭桥手术的患者随机分成两组,对照组给予常规血管保存液处理血管桥,观察组给予含L-Arg的血管保存液处理血管桥.结果:(1)移植4周后,各组静脉均有内膜及中膜较正常颈静脉明显增厚表现,左旋精氨酸组内膜及中膜增厚较对照组轻.两组静脉桥的管腔狭窄程度进行比较存在明显差异.(2)两组手术成功率无显著性差异(P＞0.05).观察组术后细胞间黏附分子-1 (ICAM-1)、内皮素-1(ET-1)及血管细胞黏附分子-1(VCAM-1)水平均较术前有明显降低(P＜0.05),且与对照组比较有统计学意义(P＜0.05).结论:(1)兔静泳移植至股动脉后内膜及中膜增厚.(2)左旋精氨酸联合降脂药物能抑制移植静脉内膜及中膜增生,减少静泳桥狭窄.(3)含有左旋精氨酸的血管保护液可一定程度上改善血管内皮细胞的功能,从而延缓血管硬化,并有效控制病情进展.     

吸毒所致感染性心内膜炎的外科治疗

目的：报告4例吸毒所致感染性心内膜炎的外科治疗。方法：浅低温体外循环下行三尖瓣赘生物切除、DeVega术3例，二尖瓣赘生物摘除、瓣膜置我术1例。结果：4例病人均痊愈出院。结论：吸毒所致感染性心脏瓣膜赘生物、瓣膜损伤必需尽早手术治疗，损坏瓣膜尽量修复保留。     

带膜血管内支架在治疗胸主动脉夹层中的应用

目的:总结带膜血管内支架置入治疗DebakeyⅢ型主动脉夹层临床经验。方法:胸主动脉夹层8例,男6例,女2例,平均年龄(54.2±10.6)岁。经CT增强扫描或磁共振成像确诊。切开右或左侧股动脉置入带膜血管内支架,封堵原发破口。置入后重复造影检查。随访行胸部X线平片与电子束CT检查。结果:支架置入全部成功,术后即刻造影7例无内漏,1例见少量内漏。降主动脉及腹主动脉真腔均明显扩大,远端降主动脉及分支供血均有不同程度的改善。术后随访:降主动脉及腹主动脉真腔扩大,术后造影1例有内漏者,无加重,其余患者近端夹层动脉瘤消失,夹层近端假腔内均有血栓形成。结论:带膜血管内支架置入治疗胸主动脉夹层近期疗效满意,远期疗效有待于进一步观察。     

三房心的外科治疗(附8例报道)

目的：探讨三房心的临床诊断和外科治疗方法。方法：总结了1994年至2002年,8例三房心患者施行外科手术的情况。结果：本组8例患者畸形矫治满意,术后恢复好。结论：超声心动图对于三房心的诊断具有较高的价值;三房心是一种罕见的心脏畸形,多合并其他心内畸形,手术切除左房内隔膜并同时矫治其他心内畸形可获得满意的效果。     

Monitoring of Acute Rejection after Orthotopic Heart Tranplantation

Objectives To study the monitoring of rejection after orthotopic heart thansplantation. Methods From 1998 to 2005, 10 othotopic heart thansplans were performed, and acute rejection was monitored by endomyocardial biopsy as well as by clinical features, ECG, ultrasonocardiography and blood serum determination of Tropin I, and by the combination of these methods, we analysed the monitoring of acute rejection after the heart transplantation. Results With the combination of clinical features, ECG, ultrasonocardiography and blood serum test, 5 occurences of acute rejection were judged in the postoperative course, which were comfirmed by endomyocardial biopsy to be 2 acute rejections inⅠb degree, 3 acute rejections inⅢa degree. Endomyocardial biopsy were routinely performed 21 times postoperatively in which there were 1 acute rejection inⅠa degree and 5 acute rejections inⅠb degree. Conclusions Acute rejection is an important factor influencing the postoperative course of heart transplantation, so it is imperative to have an in-time, effective and planned monitoring procedure for acute rejection. Endomyocardial biopsy is a sensitive and reliable method in diagnosis of acute rejection, but it is invasive and probable for some complications. The noninvasive method such as clinical features, ECG, ultrasonocardiography and blood serum test can be used as additive means in the diagnosis of acute rejection. Endomyocardial biopsy should be combined with some noninvasive methods in monitoring acute rejection after the heart transplantation.