外周血血小板计数在ICU脓毒血症患者30d死亡率预测中的价值

目的 分析血小板计数和重症监护病房(ICU)脓毒血症患者死亡的关系,评价血小板计数在ICU脓毒血症患者入院30 d预后评估的应用价值。方法 采用回顾性病例对照研究分析2022年1-12月该院收治的117例ICU脓毒血症患者临床资料,分析血小板计数与急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)评分、死亡风险系数及序贯器官衰竭(SOFA)评分的关系,及其对ICU脓毒血症患者入院后30 d内预后的评估价值。绘制Kaplan-Meier生存曲线,分析ICU脓毒血症患者血小板计数和患者总生存率的关系。结果 根据入院后30 d内的存活情况,117例脓毒血症患者被分为存活组(80例)和死亡组(37例),两组年龄、性别比较,差异无统计学意义(P>0.05);与存活组比较,死亡组血小板计数降低,APACHEⅡ评分、死亡风险系数、SOFA评分升高(P<0.05);血小板计数与APACHEⅡ评分、死亡风险系数无关(P>0.05),而与SOFA评分呈负相关(r=-0.324,P<0.05);受试者工作特征(ROC)曲线分析结果表明,ICU脓毒血症患者血小板计数、APACHEⅡ评分、...     

HEARING SHIFT AND INNER EAR PATHOLOGY OF GUINEA PIGS EXPOSED TO OCTAVE BANDS OF NOICE CENTERED AT 63 Hz AND 4kHz

Twenty-four guinea pigs with normal Preyer's reflex were exposed to the octave bands of noise centered at 63 Hz and 4 kHz, 110 dB SPL. The duration of exposure was 4 and 8 hours respectively. The permanent shift of the guinea pigs at the above two frequencies was at 4-8 kHz. As the duration of exposure were 4 hours, the threshold shift at 63 Hz was smaller than that at 4 kHz. But as the duration of exposure was 8 hours, the threshold shift at 63 Hz and 4 kHz was almost the same. No morphological change of the inner ear was observed in the guinea pigs exposed for 4 hours at the octave bands of noise centered at 63 Hz and 4 kHz, but ultrastrnetural abnormalities were noted. After the animals were exposed for 8 hours, morphological, ultrastructural changes in the inner ear were observed. The main pathologic changes were seen at the second turn of the cochlea. These changes in hearing physiology and pathology suggest that a high intensive low frequency noise can result in high frequency hearing loss and that     

A LIVER-TUMOR ADHESION PEPTIDE FROM RANDOM PHAGE DISPLAY LIBRARY

Objective： To identify and localize the synthesized targeting peptide A54 to liver cancer cell line BEL-7402 in vivo and in vitro for confirming the potential clinical application of peptide A54 in hepatocarcinoma targeting therapy. Methods： Phage A54 was confirmed by ELISA. Biotin and FAM labeled A54 peptides were identified and localized by means of jmmunohistochemistry and immunocytochemistry. Results： A54 peptide could target the liver-rumor tissue in vivo and adhere to several liver-rumor cells in vitro. FAM-labeled A54 peptides were localized on the membrane surface of liver-rumor cells. Conclusion： Synthesized A54 peptide obtained from in vivo phage display technology still kept special abilityto adhere liver-rumor cell in vivo and in vitro. The A54 peptide could be a candidate carrier for hepatocarcinoma targeting therapy.     

铜陵市小学生肠道蠕虫感染监测结果分析

按照《安徽省土源性线虫病监测方案》要求,铜陵市疾病预防控制中心多年来对市属辖区开展小学生肠道蠕虫感染监测工作,为掌握城市14岁以下儿童肠道蠕虫感染现状,制定相关防治对策和评价防治效果提供科学依据。现对2007-2013年铜陵市小学生肠道蠕虫感染情况分析报道如下。