健脑通络汤对缺血大鼠脑组织神经营养因子含量影响的研究

目的 从神经营养因子环节探讨健脑通络汤(即补阳还五汤合六味地黄汤)抗脑缺血损伤的机制,并观察补阳还五汤与六味地黄汤是否有协同作用.方法 采用改良Haruo Nagasawa法复制老龄大鼠脑缺血模型,随机分为健脑通络汤组、六味地黄汤组、补阳还五汤组、模型组、假手术组,观察各组术后24h、72h、7d脑组织TGF-β1、GDNF的表达.结果 健脑通络汤能提高急性持续脑缺血大鼠的TGF-β1、GDNF阳性细胞总数,使其表达增强,其作用优于单用,其中单用补阳还五汤优于单用六味地黄汤.结论 通过诱导内源性神经营养因子的表达,可能是健脑通络汤脑保护的作用机制.     

小儿急性肠套叠麻醉下气灌肠复位126例报告

目的寻找提高小儿急性肠套叠复位成功率的良好措施。方法对126例单纯空气灌肠复位未成功的急性肠套叠患儿,实施麻醉下气灌肠复位治疗。结果全部病例均复位成功,疗效满意。结论麻醉下气灌肠复位能显著提高小儿急性肠套叠复位成功率。     

五倍子丹参膏治疗瘢痕疙瘩38例临床观察

目的:观察五倍子丹参膏治疗瘢痕疙瘩的临床疗效.方法:选择瘢痕疙瘩患者109例、共197块瘢痕疙瘩,随机分为治疗组、对照1组和对照2组,分别予以五倍子丹参膏外敷、黑布药膏外敷和复方倍他米松注射液皮损内注射治疗,治疗前及治疗后1、3、6个月各积分1次,疗程结束后评判疗效.结果:疗程结束后治疗组治疗前和治疗后6个月积分比较有...     

脑卒中患者血清ICAM-1、CD62P、CRP变化及其临床意义

目的探讨细胞间黏附分子-1（ICAM-1）、P-选择素（CD62P）和C反应蛋白（CRP）在脑卒中发生发展中的作用。方法采用ELISA法测定68例脑卒中患者血清ICAM-1、CD62P水平,免疫比浊法检测CRP水平,并进行相关性分析。结果脑卒中患者的ICAM-1、CD62P和CRP水平明显高于对照组（36例体检正常者）,P〈0.05;ICAM-1、CD62P与CRP呈明显正相关（P〈0.05）。结论脑卒中患者血清ICAM-1、CD62P和CRP水平明显升高;其水平变化可指导脑卒中的诊断、治疗及预后判断。     

应用圆形分布法分析疟疾的发病季节

[目的]了解周宁县疟疾发病是否存在明显的季节性,为疟疾监测和控制提供科学依据。[方法]以圆形分布的理论和方法,先求出疟疾发病的集中度(r),后进行均匀性检验,若r与零在0.05水平上有显著差异,再求出角均数(α)和角离差(S),以推算集中时间和高峰期。[结果]我县1981—1988年疟疾发病的集中时间为5月8日(3月1日零时为零度角,α=66.41°),发病高峰期是3月4日至8月3日(S=84.75°);青壮年、男性和外流人员多发。[结论]我县1981—1988年疟疾有明显的季节性,好发时间有向温热季节集中趋势。近几年疟疾发病率低,仍不遗余力地加强外来流动人口和外出回归人员的监测和管理,加强蚊媒监测,以控制疟疾流行。     

环戊硫酮治疗干眼的临床疗效评价

Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.     

微量泵持续胰岛素泵入与皮下注射治疗胸部术后合并2型糖尿病的对比研究

微量泵在胸外科被广泛用于精确、恒定地输注血管活性药物和控制补液，我们受胰岛素泵持续皮下输注胰岛素治疗糖尿病的启发，2002年2月至2005年1月对64例合并2型糖尿病施行胸外科术后患者，采用微量泵持续胰岛素泵入与传统皮下注射控制术后的高血糖进行对比研究，显示了微量泵持续胰岛素泵入能够取得更好的疗效，现报告如下。     

宁波市86株结核抗酸菌耐药性测定分析

宁波市８６株结核抗酸菌耐药性测定分析浙江省宁波市卫生防疫站３１５０１０金春光，徐霞芬，林辉结核菌对抗铸药物的耐药状况，对结核病化疗效果具有重要的影响，越来越引起临床医生的关注。为了解本地区结核抗酸菌耐药状况，特时本站１９９０年１月至１９９４年１２月期...     

高龄患者心脏跳动中瓣膜置换术21例临床分析

1995年 7月至 2 0 0 1年 7月我科对 2 1例 6 0岁以上的高龄患者进行心脏跳动中瓣膜置换术 ,现将结果报道如下。1　资料与方法1.1　一般资料 :本组共 2 1例 ,其中男 11例 ,女 10例。年龄 6 0～ 6 9岁 ,平均 6 2 .2岁。行二尖瓣置换术 14例 ,主动脉瓣置换术 3例 ,二尖瓣及主动脉瓣置换术 4例。合并糖尿病5例 ,高血压 4例 ,肾功能不全 1例 ,房颤 8例。风湿性瓣膜病 15例 ,(其中曾经进行过二尖瓣闭式或球囊扩张术的有 3例 ) ,老年性退行性变 6例。心胸比率 0 .5 6～ 0 .74。1.2　方法 :常规建立体外循环 ,二尖瓣置换者不阻断主动脉 ,主动脉瓣及…     

KBT一次性抗菌纸内裤的抗菌效果

用洗必泰和成膜剂整理的一次性抗菌纸内裤,经Quinn抗菌检测有良好与持久的抗菌作用. 实际使用效果,抗菌纸内裤使用1～3天后抑菌率分别为99.5%和92.3%