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52.
羊水栓塞是在分娩过程中羊水突然进入母体血液循环引起急性肺栓塞、休克、弥散性血管内凝血、肾衰竭或突发死亡的分娩严重并发症。发生于足月妊娠时产妇死亡率高达70%-80%。我科在2002年6月-2004年7月2年中曾遇3例羊水栓塞患者,现将3例患者的发病原因和诊治过程报告如下。 相似文献
53.
目的 探讨高迁移率族蛋白B1(HMGB1)对高糖诱导的晶状体上皮细胞(LEC)凋亡和自噬的影响。方法 本研究以糖尿病性白内障患者和年龄相关性白内障(ARC)患者晶状体前囊膜以及高糖和正常糖条件下培养的人晶状体上皮细胞株(SRA01/04)为研究对象。选取2021年10月至2022年3月在南通大学第二附属医院眼科确诊为白内障的患者20例,依据白内障类型分为糖尿病性白内障组(DC组)和ARC组,每组各10例,取患者晶状体前囊膜进行实验。将细胞分为正常糖组和高糖组,正常糖组培养基含5.5 mmol·L-1葡萄糖,高糖组培养基含25.0 mmol·L-1葡萄糖,处理24 h后进行实验。采用Western blot检测各组HMGB1蛋白的表达水平。利用siRNA技术对HMGB1进行敲降,将细胞分为正常对照组、scr-siRNA组和si-HMGB1组。正常对照组:不作任何处理;scr-siRNA组:加入等量的Lipofectamine 3000和scr-siRNA;si-HMGB1组:加入等量的Lipofectamine 3000和si-HMGB1。三组... 相似文献
54.
目的 研究数字化X射线胸部高千伏摄影曝光剂量与图像质量的关系,确定数字化X射线摄影最佳曝光剂量。方法 选择胸部高千伏摄影管电压120 kV,摄影mAs从1 mAs逐档增加至25 mAs,对模拟人体胸部厚度摄影体模与CDRAD 2.0对比度细节体模进行摄影,测量体模表面X射线入射剂量,由5位观察者独立阅读体模影像,比较任意两曝光条件组之间的图像质量因子(IQF),确定高千伏胸部摄影最佳条件。比较4和10 mAs条件下正常人体胸部摄影图像质量评分。结果 胸部高千伏摄影体模曝光条件从1 mAs增加到25 mAs,体模表面X射线入射剂量从0.067 mGy增加至1.468 mGy。随着X射线入射剂量的增加,影像质量影响因子IQF值不断减小,观察者阅读体模信号的IQF差异有统计学意义(F=31.00,P<0.05),曝光剂量条件选择在1~4 mAs时所对应的IQF均值差异有统计学意义(F=15.3,P<0.05),4~10 mAs时所对应的IQF差异无统计学意义,10~25 mAs时所对应的IQF均值差异有统计学意义(F=9.74,P<0.05)。曝光剂量条件选择4和10 mAs所对应的体模表面入射剂量为0.250和0.606 mGy,两种条件下胸部图像质量的综合评分分别为(24.8±1.64)、(25.8±2.05)分,差异无统计学意义。结论 随着数字化X射线摄影剂量的增加所获得图像信息量增加。满足临床诊断的标准人体胸部高千伏数字化X摄影最佳剂量为0.250 mGy左右。 相似文献
55.
目的 分析鼻底及相关上气道解剖特征与阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的相关性。方法 50例OSAHS患者和40例对照组研究对象均接受多道睡眠图监测及上呼吸道三维CT检查。对比组间各参数差异,分析上气道解剖特征与睡眠监测参数间的相关性。结果 两组间多个CT指标均具有显著性的差异,包括腭咽腔与舌咽腔的最小左右径及最小截面积、腭咽腔的最小前后径以及鼻底气道宽度(P 均<0.05)。logistic回归分析提示腭咽最小截面积及鼻底气道宽度是OSAHS发生与否的独立预测因素(风险比值比分别为0.978及0.589,P <0.05)。相关分析提示鼻底气道宽度及鼻底气道面积均与多项咽腔CT指标显著相关(P <0.05),其中二者与腭咽腔最小截面积的相关系数分别为0.536及0.425。结论 鼻底及腭咽腔狭窄是OSAHS发生的独立解剖危险因素,鼻底部位的气道特征与下游咽腔的解剖特征相关。 相似文献
56.
Objective To analyze the proguostic factors for chronic lymphocytic leukemia (CLL) with typical and atypical immunophenotype. The parameters analyzed included sex, age, Binet stages, abso-lute lymphocyte count (ALC), immunoglobulin heavy-chain variable region (IgVH) gene mutation status, ZAP-70 protein, CD38 expression and cytogenetic aberrations. Methods According to the clinical guideline and scoring system for CLL in Britain, among 77 patients, 61 patients with score 5 called typical immunophe-notype CLL, 16 with score 4 or 3 were atypical immunophenotype CI,L. Multiparameter flow cytometry was employed for immunophenotypic analysis in 77 CLL patients for CD5, CD19, CD23, FMC7, slg, CD20, CD79h expression and ZAP-70 protein and CD38. IgVH mutation status was detected by multiplex RT-PCR and sequencing of the purified PCR amplification products. Fluorescence in situ hybridization (FISH) and a panel of probes were used to detect cytogenetic aberrations. Results There was no significant difference be-tween the two groups in sex, age, ZAP-70 and IgVH mutation status (P =0.398, P =0. 189, P =0.268 and P =0. 131, respectively). The incidence of ALC≥50 × 109/L, Binet B + C, CD38 ≥30% in atypical CLL patients(43.8%, 87.5% and 43.8%, respectively) were higher than that in typical group (16.4%, 36.1% and 16.4%, respectively) (P = 0. 026, P < 0. 01 and P = 0. 026, respectively). The proportion of typical patients (26. 8%) with a 13q14 deletion as sole abnormality was higher than that of atypical patients (7.6%), and that with deletion of 11q22 or 17p13 was lower than that of atypical patients (12.2% vs 46.2%) (P = 0. 022). Conclusion There were obvious differences between the typical immunophenotype CLL and atypical CLL in ALC, Binet stages, CD38 expression level and cytogenetic aberrations. 相似文献
57.
目的了解乳腺癌患者一级亲属对乳腺癌早期筛查认知情况及探讨其影响因素,为临床针对性开展护理干预和健康教育提供理论依据和指导。方法选取2013年8月至2014年1月本院乳腺治疗中心乳腺癌患者一级亲属213例作为研究对象,采用问卷调查的形式分析乳腺癌患者一级亲属对乳腺癌早期筛查认知情况及其影响因素。结果乳腺癌患者一级亲属对乳腺癌疾病相关知识获取途径主要来源于亲属住院期间的健康教育(29.11%)和医护人员(24.41%);在乳腺癌高危因素认知上主要有认为其发病与乳腺良性疾病史(65.73%)、长期服用激素(64.32%)和家族史(61.03%)有关,在临床表现上,主要认为乳腺癌的临床表现为乳房肿块(88.26%);在早期筛查方法上,主要通过乳房临床检查(52.11%);乳腺癌相关知识认知程度与乳腺癌患者一级亲属居住地、有无职业和文化程度有关(P0.05),与年龄和婚姻状况无关(P0.05);乳腺癌患者一级亲属主要希望通过邮寄资料获取相关健康教育知识。结论乳腺癌患者一级亲属对乳腺癌早期筛查认知不足,应加大预防乳腺癌相关知识的健康教育,并注意不同居住地、职业和文化程度的宣传教育方式,努力提高防癌意识。 相似文献
58.
Objective To analyze the proguostic factors for chronic lymphocytic leukemia (CLL) with typical and atypical immunophenotype. The parameters analyzed included sex, age, Binet stages, abso-lute lymphocyte count (ALC), immunoglobulin heavy-chain variable region (IgVH) gene mutation status, ZAP-70 protein, CD38 expression and cytogenetic aberrations. Methods According to the clinical guideline and scoring system for CLL in Britain, among 77 patients, 61 patients with score 5 called typical immunophe-notype CLL, 16 with score 4 or 3 were atypical immunophenotype CI,L. Multiparameter flow cytometry was employed for immunophenotypic analysis in 77 CLL patients for CD5, CD19, CD23, FMC7, slg, CD20, CD79h expression and ZAP-70 protein and CD38. IgVH mutation status was detected by multiplex RT-PCR and sequencing of the purified PCR amplification products. Fluorescence in situ hybridization (FISH) and a panel of probes were used to detect cytogenetic aberrations. Results There was no significant difference be-tween the two groups in sex, age, ZAP-70 and IgVH mutation status (P =0.398, P =0. 189, P =0.268 and P =0. 131, respectively). The incidence of ALC≥50 × 109/L, Binet B + C, CD38 ≥30% in atypical CLL patients(43.8%, 87.5% and 43.8%, respectively) were higher than that in typical group (16.4%, 36.1% and 16.4%, respectively) (P = 0. 026, P < 0. 01 and P = 0. 026, respectively). The proportion of typical patients (26. 8%) with a 13q14 deletion as sole abnormality was higher than that of atypical patients (7.6%), and that with deletion of 11q22 or 17p13 was lower than that of atypical patients (12.2% vs 46.2%) (P = 0. 022). Conclusion There were obvious differences between the typical immunophenotype CLL and atypical CLL in ALC, Binet stages, CD38 expression level and cytogenetic aberrations. 相似文献
59.
Objective To analyze the proguostic factors for chronic lymphocytic leukemia (CLL) with typical and atypical immunophenotype. The parameters analyzed included sex, age, Binet stages, abso-lute lymphocyte count (ALC), immunoglobulin heavy-chain variable region (IgVH) gene mutation status, ZAP-70 protein, CD38 expression and cytogenetic aberrations. Methods According to the clinical guideline and scoring system for CLL in Britain, among 77 patients, 61 patients with score 5 called typical immunophe-notype CLL, 16 with score 4 or 3 were atypical immunophenotype CI,L. Multiparameter flow cytometry was employed for immunophenotypic analysis in 77 CLL patients for CD5, CD19, CD23, FMC7, slg, CD20, CD79h expression and ZAP-70 protein and CD38. IgVH mutation status was detected by multiplex RT-PCR and sequencing of the purified PCR amplification products. Fluorescence in situ hybridization (FISH) and a panel of probes were used to detect cytogenetic aberrations. Results There was no significant difference be-tween the two groups in sex, age, ZAP-70 and IgVH mutation status (P =0.398, P =0. 189, P =0.268 and P =0. 131, respectively). The incidence of ALC≥50 × 109/L, Binet B + C, CD38 ≥30% in atypical CLL patients(43.8%, 87.5% and 43.8%, respectively) were higher than that in typical group (16.4%, 36.1% and 16.4%, respectively) (P = 0. 026, P < 0. 01 and P = 0. 026, respectively). The proportion of typical patients (26. 8%) with a 13q14 deletion as sole abnormality was higher than that of atypical patients (7.6%), and that with deletion of 11q22 or 17p13 was lower than that of atypical patients (12.2% vs 46.2%) (P = 0. 022). Conclusion There were obvious differences between the typical immunophenotype CLL and atypical CLL in ALC, Binet stages, CD38 expression level and cytogenetic aberrations. 相似文献
60.
仑伐替尼是继索拉非尼之后FDA首次批准的晚期肝细胞癌(hepatocellular carcinoma,HCC)一线用药,临床研究显示其疗效与索拉非尼相当,并在某些方面更具优势。然而,伴随仑伐替尼的大规模使用,近年来其临床耐药问题也引起高度关注。表皮生长因子受体(EGFR)激活、成纤维细胞生长因子受体1 (FGFR1)过表达及HCC中肿瘤干细胞出现等为仑伐替尼耐药的重要原因。面对仑伐替尼耐药,一些创新性研究也取得了积极进展,如仑伐替尼联合免疫检查点抑制剂经临床试验证实具有良好疗效,成为新兴的HCC治疗策略。本文总结了近年关于仑伐替尼耐药机制及创新性应对策略的研究成果,为HCC患者进行仑伐替尼治疗提供新的参考。 相似文献