三尖瓣绞锁缝合瓣环化成形技术

2000年11月至2006年11月我们采用绞锁缝合瓣环化成形术(TVP)对108例中、重度功能性三尖瓣反流病人进行了三尖瓣成形术治疗,现总结报道如下.     

In vitro lipofectamine mediated NF-κB decoy oligodeoxynucleotides transfection of Kupffer cells

Objective To study the transfection effects of nuclear factor-KappaB(NF-κB)decoy oligodeoxynucleotides(ODN) to Kupffer cells (KCs) mediated by lipofectamine,and investigate it's suppression effects on KCs activation. Methods Twenty-four Wistar rats were divided into three groups (n=8).(1)Control group,in which the normal KCs were isolated.(2)LPS group,in which 1 ms/L LPs was added to the culture system.(3)NF-κB decoy ODN group,in which KCs were transduced with NF-κB decoy ODN (4μg×105KCs)prior to LPS stimulation.The transfection efficiency Was assayed,and the phagocytosis function,NF-κB(P65) translocation,CD40 mRNA expression of KCs were also detected respectively. Results Kupffer cells were obviously activated after LPS stimulation.the phagocytosis function was reinforced.the activity of NF-κB transloeated from cytoplasm into nucleus was obviosly increaced.The co-stimulatory molecules expression(CD40 mRNA)significantly increased compared with control group(t=4.01,P<0.01).NF-κB decoy oligodeoxynucleotides can efficiently transfected into KCs mediated by lipofectamine,which can obviously suppress KCs activation,and downregulate the expression of downstream gene(compared with LPS group,t=4.89,P<0.01). Condusion NF-κB decoy ODN can efficiently transfect into KCs and inhibit it's activation.     

螺旋CT和彩色多普勒血流显像检查对胰腺癌可切除性的评估价值

Objective To determine the value of helical computed tomography (HCT) and color doppler flowing imaging (CDPI) in evaluating the resectability of pancreatic cancer. Methods The clinical data of 114 patients with pancreatic cancer who had been admitted to the Affiliated Hospital of North Sichuan Medical College from January 1995 to December 2002 were retrospectively analyzed. The values of HCT and CDPI in assessing the resectability of pancreatic cancer were determined according to the results of operation and pathological examina-tion. All the data were analyzed by chi-square test and Fisher exact probability. Results Of all patients, 109 were examined by HCT, 97 by CDPI and 96 by HCT+CDPI. For patients examined by HCT, the resection rates of pancreatic head cancer, pancreatic body and tail cancer and total pancreatic cancer were 45.3% (39/86), 26.3% (5/19) and 0 (0/9), respectively. The resection rate of pancreatic head cancer was higher than that of pancreatic body and tail cancer (χ2=8.965, P<0.05). With the increase of tumor size, the invasion rate and metastasis rate were increased and the resection rate was decreased (z=6.15, 5.35, 7.18, P<0.01). The sensitivity rate and specificity rate were 77.8% and 82.2% of HCT, 73.3% and 80.6% of CDPI, 90.6% and 92.4% of HCT+CDPI in assessing the resectability of pancreatic cancer. The values of Kappa identity test of HCT, CDPI and HCT+CDPI were 0.58, 0.52 and 0.82, respectively. Conclusions Combined application of HCT and CDPI can further improve the accuracy in assessing the resectability of pancreatic cancer.     

机关职员7192例慢病风险因子分析与健康管理对策

随着社会经济的发展和人民生活水平的提高,慢性非传染性疾病已经成为国家疾病预防控制策略的重点。为了了解本区机关人群的健康状况,探讨该人群的慢性风险因子和健康管理的方式方法,从2007年5月18日至12月底,我院体检科对全区职员进行了健康体检,其结果分析如下：     

胃酸测定在预防和治疗重度外伤患者应激性溃疡中的应用

目的:评价胃酸测定在预防和治疗重度外伤患者应激性溃疡中的作用。方法:随机抽取重度外伤患者79例,分成3组,胃酸pH≥3.5雷尼替丁组、pH<3.5雷尼替丁组和pH<3.5奥美拉唑组,治疗1周后比较3组溃疡病例发生率。结果:胃酸pH≥3.5雷尼替丁组溃疡发生率10.5%,与pH<3.5雷尼替丁组30.0%和奥美拉唑组27.3%均差异显著(均P<0.05);pH<3.5雷尼替丁和奥美拉唑2组间差异无统计学意义(P>0.05)。结论:重度外伤患者当胃酸pH<3.5时易发生应激性溃疡,应予以预防用药;H2受体阻滞剂和质子泵抑制剂预防疗效无显著性差异,可根据经济情况合理选用。     

保留齿状线内悬吊外切剥术治疗混合痔的临床研究

目的 探讨保留齿状线内悬吊外切剥术治疗混合痔的临床疗效.方法 将68例混合痔患者随机分为两组,治疗组(34例)采用保留齿线内悬吊外切剥术治疗,对照组(34例)采用外剥内扎硬注术治疗.观察两组患者疗效,术后并发症,术后肛门功能情况,手术时间,住院天数,切口愈合时间.结果 两组临床疗效相比差异无统计学意义(P>0.05);术后肛门疼痛、住院天数和切口愈合时间差异有统计学意义(P<0.05);术后肛门功能方面差异无统计学意义(P>0.05).结论 保留齿线内悬吊外切剥术能有效治疗混合痔,并且减轻术后并发症,缩短切口愈合时间及住院天数,是一种安全、有效、经济、适宜推广的治疗混合痔的新方法.     

螺旋CT和彩色多普勒血流显像检查对胰腺癌可切除性的评估价值

Objective To determine the value of helical computed tomography (HCT) and color doppler flowing imaging (CDPI) in evaluating the resectability of pancreatic cancer. Methods The clinical data of 114 patients with pancreatic cancer who had been admitted to the Affiliated Hospital of North Sichuan Medical College from January 1995 to December 2002 were retrospectively analyzed. The values of HCT and CDPI in assessing the resectability of pancreatic cancer were determined according to the results of operation and pathological examina-tion. All the data were analyzed by chi-square test and Fisher exact probability. Results Of all patients, 109 were examined by HCT, 97 by CDPI and 96 by HCT+CDPI. For patients examined by HCT, the resection rates of pancreatic head cancer, pancreatic body and tail cancer and total pancreatic cancer were 45.3% (39/86), 26.3% (5/19) and 0 (0/9), respectively. The resection rate of pancreatic head cancer was higher than that of pancreatic body and tail cancer (χ2=8.965, P<0.05). With the increase of tumor size, the invasion rate and metastasis rate were increased and the resection rate was decreased (z=6.15, 5.35, 7.18, P<0.01). The sensitivity rate and specificity rate were 77.8% and 82.2% of HCT, 73.3% and 80.6% of CDPI, 90.6% and 92.4% of HCT+CDPI in assessing the resectability of pancreatic cancer. The values of Kappa identity test of HCT, CDPI and HCT+CDPI were 0.58, 0.52 and 0.82, respectively. Conclusions Combined application of HCT and CDPI can further improve the accuracy in assessing the resectability of pancreatic cancer.     

胃癌131I-MG7瘤内注射药代动力学及辐射剂量估算(附二例报告)

胃癌１３１ＩＭＧ７瘤内注射药代动力学及辐射剂量估算（附二例报告）张裕民邓敬兰彭勇秦云才杨思齐附表２例胃癌患者瘤内注射１３１ＩＭＧ７后器官（组织）吸收剂量（ｍＧｙ／ＭＢｑ）例号注射剂量（ＭＢｑ）肝肾胃组织肠道全身骨髓血样法骶骨显像法１２４６２．５４...     

新生儿多发畸形1例

1 病例介绍 患儿于生后3天无明显诱因出现周身皮肤黄染,因患儿进乳及二便正常而未引起家长注意.直到近满月黄疸逐渐加重,故来我院儿科就诊.门诊以新生儿病理性黄疸收入院.