血管细胞黏附分子-1与脑缺血再灌注损伤研究进展

近年来,黏附分子在脑缺血再灌注损伤中的作用已成为研究的热点之一[1].血管细胞黏附分子-1(vascular cell adhesion molecule-1,VCAM-1)是一种重要的黏附分子,现就其与脑缺血再灌注损伤的关系做一综述.     

新生儿缺氧缺血性脑病淋巴细胞凋亡与血浆游离钙相关性研究

目的:了解新生儿缺氧缺血性脑病淋巴细胞凋亡的情况以及血浆游离钙和淋巴细胞凋亡之间的关系。方法:采用流式细胞仪测定30例新生儿缺氧缺血性脑病患儿急性期淋巴细胞凋亡,采用I-STAT1-Analyzer测定血浆游离钙,并以同期在新生儿科住院的30例足月早期新生儿作为对照组,均为羊水吸入综合征和咽下综合征患儿。结果:新生儿缺氧缺血性脑病患儿淋巴细胞经体外培养24h后,其最大凋亡率较对照组明显增加(P<0.05),且血浆游离钙和淋巴细胞凋亡呈负相关。结论:新生儿缺氧缺血性脑病时血浆游离钙降低,外周血淋巴细胞凋亡加速。     

通心络治疗冠心病心绞痛62例疗效观察分析

目的 了解通心络胶囊对冠心病心绞痛的治疗作用。方法 将确诊的冠心病心绞痛患者62例随机分为2组，在常规治疗的基础上，治疗组加用通心络胶囊4粒1日3次服，对照组加用正心泰胶囊4粒1日3次口服。4周为一疗程。结果 治疗组在改善临床症状及心电图的改善，心律失常的纠正优于对照组。结论 通心络胶囊可改善心肌功能，且副作用少，有利于提高疾病的治愈率。     

逆行荧光标记观察猫上橄榄复合体向内耳的投射

Objective To investigate the distribution and projective feature of cat olivocochlear neurons. Methods Eleven adult cats were divided into two groups randomly. The experimental group of eight cats was injected of I% cholera toxin B (CTB) to the left cochlea, while injected of 5% fluoro gold (FG) to the right cochlea. The control group of three cats was injected of saline to bilateral cochlea. After a survival time of 7 days, serial frozen sections were cut in the cat brainstem. All the sections were processed by immunofluoreseent procedure for CTB and FG, and the labeled olivocochlear neurons were observed byfluorescent microscope. Results In the experimental group, the mean total of olivocochlear neurons labeled by CTB and FG was 3210 ± 168, including lateral olivocochlear neurons (LOC, 2298 ± 120) and medial olivocochlear neurons (MOC,913 ± 64). The labeled neurons were divided into three different types according to their feature of projection: neurons which only projected to the ipsilateral cochlea, neurons which only projected to the contralateral cochlea, and double-labeled neurons which projected both to the ipsilateral and contralateral cochlea, but the double-labeled neurons comprised 3.9% and 15. 1% in the LOC and MOC system respectively. No labeled neurons were found in the control group. Conclusions There are three types of neurons in the cat olivocochlear system. The neurons which projected to the bilateral cochlea may distribute both in the LOC and MOC system.     

逆行荧光标记观察猫上橄榄复合体向内耳的投射

Objective To investigate the distribution and projective feature of cat olivocochlear neurons. Methods Eleven adult cats were divided into two groups randomly. The experimental group of eight cats was injected of I% cholera toxin B (CTB) to the left cochlea, while injected of 5% fluoro gold (FG) to the right cochlea. The control group of three cats was injected of saline to bilateral cochlea. After a survival time of 7 days, serial frozen sections were cut in the cat brainstem. All the sections were processed by immunofluoreseent procedure for CTB and FG, and the labeled olivocochlear neurons were observed byfluorescent microscope. Results In the experimental group, the mean total of olivocochlear neurons labeled by CTB and FG was 3210 ± 168, including lateral olivocochlear neurons (LOC, 2298 ± 120) and medial olivocochlear neurons (MOC,913 ± 64). The labeled neurons were divided into three different types according to their feature of projection: neurons which only projected to the ipsilateral cochlea, neurons which only projected to the contralateral cochlea, and double-labeled neurons which projected both to the ipsilateral and contralateral cochlea, but the double-labeled neurons comprised 3.9% and 15. 1% in the LOC and MOC system respectively. No labeled neurons were found in the control group. Conclusions There are three types of neurons in the cat olivocochlear system. The neurons which projected to the bilateral cochlea may distribute both in the LOC and MOC system.     

消化性溃疡临床用药

目的：系统介绍消化性溃疡用药,供临床合理用药参考。方法：通过简要介绍治疗消化性溃疡代表性药物的作用特点,了解各类药物的具体应用。结果和结论：使临床医师能较好地根据该类药物中各种药物的特点,正确地选择药物。     

番泻叶用于剖宫产术后肠功能恢复临床体会

我院妇产科采用单味番泻叶泡水代茶饮促进剖宫产术后肠功能恢复 ,经临床观察其促进肠蠕动 ,恢复肠鸣音作用时间及副反应等均优于期待组 ,现报道如下。1　临床资料我院自 1 996年 9月到 1 999年 3月的 60例剖宫产术后产妇 ,年龄 2 5至 3 3岁 ;初产妇 5 4例 ,经产妇 6例 ;手术方式均为子宫下段剖宫产 ,采用连续硬膜外麻醉。将其随机分为二组 ,即治疗组(番泻叶 )和对照组 (不用药 )各 3 0例 ,两组年龄孕产史、手术过程均相似 ,有可比性。2　用药方法　　治疗组术后 8小时即给予番泻叶 5 g,开水浸泡后代茶饮 ,少量多次 ,以肛门排气或排便为止 ,…     

深圳市某区学龄前儿童丙型肝炎血清流行病学调查

目的:C型肝炎目前并未有疫苗预防接种,因此对C型肝炎的流行情况、尤其是C型肝炎病毒的致病机转及感染途径方面的探讨,以其切断感染源,是为迫切需要.方法:以多步骤抽样法在区、街道中心与郊乡地区筛检54所幼儿园.从静脉采血取得血清,以自动化仪器测试肝功能指针研究数据,以SPSS软件系统做统计分析.结果:有19位儿童为C型肝炎抗体阳性,占2.3%.男孩的C型肝炎抗体流行率比女孩高,但经统计学处理无显著差异(0Rm:1.6;95% CI:0.9～2.8;P=0.08).3～4岁年龄段的流行率比5～6岁低(ORm:2.2;95% CI:1.1～4.2;P=0.02).经多变项调整分析后,具C型肝炎抗体流行率的儿童且受B型肝炎病毒自然感染的比未被感染的高,但经统计学处理无显著差异(ORm:2.6;95% CI:0.9～7.4;P=0.08 for HBV-infected vs. uninfected).结论:在龙岗区,C型肝炎病毒的感染与B型肝炎病毒自然的感染,除了性别与居住地外,应该还有更多的共同传染途径存在.另外,为数不少的居民相信药物注射比口服治疗快,尤其是对儿童的治疗,因此间接造成C型肝炎病毒感染的数量增加.