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in order to elucidate the different resultsobtained in cancer patients with similar condition andsymptoms treated by the same medicinal herbs,an in-vestigation of the utensils used for making decoctionswas carried out.it was found that the decoction madeby mcans of glassware,enamel and earthenware potshad the best effect of Inhibiting the colony formationof human gastric carcinoma cells,the next were thedecoctions made by means of unrefined iron pots,stainless steel pots and copper pots,and the worstwas that made with aluminium pots.It was alsofound that there was no difference between the watercontained in those utensils and normal saline in theinfluence on the colony formation of human gastriccarcinoma cells.Therefore,it is believed that the dif-ference in effect of the decoctions made by means ofdifferent kinds of utensils is not due to the tracedissolution of the utensil materials,but is most likelydue to the occurence of some chemical reactions whilemaking the decoction.That the decoctions made bymeans of different utensils had different peak valuesin the absorption spectrum also supports this pro-position. 相似文献
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具有免疫抑制作用的含有聚乙二醇基的青蒿素衍生物的合成 总被引:7,自引:0,他引:7
目的寻找免疫抑制活性更高的青蒿素类化合物。方法以二氢青蒿素为原料,通过缩合、酯化反应合成两类含有聚乙二醇基的青蒿素衍生物,测定它们对体外T细胞和B细胞增殖的抑制活性。结果合成了23个含有聚乙二醇基的青蒿素衍生物(2a~2f,3a~3d,4a~4f,6a,6b和7a~7g),通过1H NMR和元素分析确定其化学结构。结论这些化合物都有一定的体外免疫抑制活性。青蒿素母核对称取代2和6的活性高于青蒿素母核单取代的3,4和7。化合物2a~2f的活性比青蒿素、青蒿琥酯高。 相似文献
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严重脓毒症和脓毒症休克是临床重症监护室患者的主要死亡原因之一。对于晚期脓毒症患者机体所处免疫应答状态目前有两种不同观点:一种观点认为,患者固有免疫和适应性免疫进入免疫抑制状态,患者主要死于初次感染清除障碍及继发感染;另一种观点认为,晚期患者固有免疫持续激活,患者主要死于炎症造成的器官损伤。临床用药应根据患者不同的发病阶段及病症选择最佳治疗方案。近年来针对脓毒症导致的机体免疫抑制而研发的药物(如抗PD1抗体、人重组IL-7、GM-CSF等)及针对炎症细胞因子MIF、HMGB1和C5a为靶点而研发的制剂,在动物实验及临床试验中均取得了一定的疗效,为脓毒症的靶向治疗带来了新希望。 相似文献
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目的 探讨胸腰段骨折椎弓根螺钉内固定后终板愈合形态对椎间盘退变的影响。方法 选择2014年1月~2019年12月在本院接受椎弓根螺钉内固定的87例单节段胸腰椎骨折患者作为研究对象,观察不同骨折分型和终板损伤类型与椎间盘退变程度的关系。结果 A1型骨折患者椎间盘退变Pfirrmann分级显著低于A2、A3、B型骨折患者(P<0.05)。无终板损伤患者的Pfirrmann分级显著低于单个终板损伤、两个终板损伤患者,单个终板损伤患者的Pfirrmann分级显著低于两个终板损伤患者(P<0.05)。2级和3级椎间盘损伤患者的Pfirrmann分级显著高于0级和1级(P<0.05)。终板不规则愈合(irregular healing, IH)和创伤性Schmorl结节(traumatic schmorl node, TSN)患者的椎间盘退变程度显著高于终板曲率增大(increased endplate curvature, IEC)的患者,差异有统计学意义(P<0.05)。结论 终板损伤的存在和严重程度可影响椎间盘退变,IH和TSN与椎间盘退变密切相关。 相似文献