榄香烯注射液对局部晚期宫颈癌患者预后的临床研究

目的:探究榄香烯注射液对局部晚期宫颈癌患者预后的影响。方法:对收治的109例局部晚期宫颈癌患者作为研究对象,随机将其分为治疗组55例和对照组54例,对治疗组患者在同步放化疗基础上加用榄香烯注射液静滴,而对照组患者仅进行同步放化疗。对两组患者的近、远期疗效及不良反应发生情况进行比较。结果:治疗组患者加用榄香烯注射液后,其近期有效率较对照组有显著升高,且随着时间的推移,治疗组患者2年、3年的生存时间亦明显延长,差异有统计学意义(P0.05);而两组患者的1年生存率及不良反应发生率无明显统计学差异(P0.05)。结论:对局部晚期宫颈癌患者在同步放化疗治疗的基础上加用榄香烯注射液静滴有良好的耐受性,并可改善患者预后,提高患者生存时间。     

212例胆道良性狭窄的临床分析

目的 分析胆道良性狭窄的原因及诊治情况,提高其防治效果.方法 回顾性分析天津市南开医院2004年1月至2006年12月胆道良性狭窄患者212例,其中3例有2处狭窄,并对其病因、诊断及治疗进行分析.结果 胆道良性狭窄主要以炎性狭窄为主,占65.12%(140/215).与手术相关的狭窄(瘢痕性狭窄及胆道损伤)占20.46%(44/215),成为第二位致狭窄原因.狭窄部位又以胆总管下段狭窄为主,占总数的52.09%(112/215).本组中采用狭窄部支撑法31.37%(64/204),胆道内引流法18.13%(37/204),狭窄部成型43.63%(89/204),狭窄段切除法1.96%(4/204).结论 炎性狭窄占良性胆道狭窄的首位,狭窄部位又以胆总管下段狭窄为主.对于胆道良性狭窄术前诊断可决定手术方式及预后,因此术前诊断方法尤为重要.胆道良性狭窄的治疗施行手术内窥镜联合治疗,其中狭窄部支撑法、胆道内引流法及狭窄部成型是主要方法.     

中医药在肾移植中的应用

近20年来,中医中药在移植学中得到了广泛的应用,特别是在肾移植中应用最为广泛。国内一些单位已对中药的抗排斥反应进行了大量研究,并有学者认为,从中药中寻找有效、低毒、价廉的免疫抑制剂具有广阔的发展前景。已有多家研究机构对中药作为辅助的免疫抑制剂进行了实验和临床研究,主要包括雷公藤、冬虫夏草的免疫抑制作用和移植前后中医的辨证论治以及中药对移植后并发症的治疗等。     

大承气颗粒、针刺足三里对腹部手术后胃肠功能影响效果的比较

[目的]探讨腹部手术后促进胃肠功能恢复的有效方法,比较大承气颗粒及针刺疗法对腹部手术之后胃肠道功能恢复效果。[方法]119例患者随机分为大承气治疗组(62例),针刺治疗组(57例),大承气治疗组从术后第1天起,给予大承气冲剂冲服或灌肠;针刺治疗组于术后第1天开始给予针刺足三里。[结果]两组相比较,大承气治疗组术后肠鸣音恢复时间时间明显少于针刺治疗组,且差异显著(P<0.05);肛门排气时间大承气治疗组少于针刺治疗组,且差异显著(P<0.05);大承气治疗组组住院时间及住院费用也少于针刺治疗组组,且差异显著(P<0.05)。[结论]大承气颗粒对于促进腹部手术后胃肠功能恢复效果要优于针刺足三里疗法,且可以使住院时间缩短,住院费用降低。     

大承气颗粒新药研制

大承气汤是《伤寒论》经方,主治阳明腑实证或热结旁流之证。自60年代以来,由天津市南开医院率先应用该方治疗急腹症,对解除单纯性机械性肠梗阻和恢复腹部手术后胃肠运动功能均有明显作用,近年来证明该方剂对腹内感染所致的肠源性内毒素血症及脏器损害有较好的防治作用。     

胆囊结石不进行手术行吗?

胆囊结石是一种常见的疾病。从尸检材料中发现,胆囊内有结石的病人生前约 有50％并无胆道疾病的症状。少数人有消化不良,偶有上腹部隐痛等。约30％,的人发生过严重的胆囊结石发作,而产生严重症状。约15％有非典型性     

改良小柴胡汤可能通过转化生长因子-β1/Sma及愤怒相关蛋白信号通路抑制大鼠慢性胰腺炎进展

Objective： To investigate the effect of modified Xiaochaihu Decoction （小柴胡汤, MXD） on transforming growth factor- [3 1/Sma- and Mad-related proteins （TGF- 13 1/Smads） signaling pathway in rats with chronic pancreatitis （CP） induced by dibutyltin dichloride. Methods： Thirty healthy male Wistar rats were randomly divided into the normal control group, CP group and CP＋MXD-treated group. CP was induced by injection of dibutyltin dichloride （DBTC, 7 mg/kg of body weight） into the right caudal vein, and the control rats were treated with vehicle. MXD was given daily by gavage at a dose of 10 g/kg of body weight, starting from the day after CP induction. After 28-day treatment, the n-benzoyl-tyrosyl para-aminobenzoic acid （NBT-PABA） test was carried out to evaluate exocrine pancreatic function. Then, rats were sacrificed, and pancreatic tissues were harvested for histological evaluation. In addition, the mRNA expression of TGF- β 1, TGF- β 1 type Ⅱ receptor （TGF β R 11 ）, Smad3 and Smad7 was determined in pancreatic tissues by using real-time polymerase chain reaction. Results： Treatment of CP with MXD improved the PABA recovery, decreased the histological lesion, and reduced the mRNA expression of TGF- β 1, TGF β R 11 and Smad3 （P〈0.05）. However, MXD had no effect on Smad7 mRNA level. Conclusions： MXD could protect the pancreas against chronic injury and improve pancreatic exocrine function in DBTC induced rat CP model. Its mechanism may involve inhibition of the TGF-β 1/Smads signaling pathway.     

通里攻下法在腹部外科疾病中的应用与基础研究

中医通里攻下法(简称下法)是指荡涤胃肠、攻实祛瘀及泻热逐邪的一种治疗方法,常用于温热病及危重病的治疗。1960年代初期以来,根据急腹症出现的功能障碍、梗阻、感染及血运障碍等不同的基本病理变化,采用通里攻下法治疗或下法与其他治则相结合,辨证施治,初步形成了一套治疗常规。 1.通里攻下法的临床研究     

Change of Th1/Th2 Cytokine Equilibrium in Rats with Severe Sepsis and Therapeutic Effect of Recombinant Interleukin-12 and Shenmai Injection(参麦注射液)

Objective: To evaluate the dynamic change of Th1/Th2 cytokines in serum, peritoneal lavage fluid (PLF) and splenic macrophages (SM) in rats with severe peritonitis, and to observe the therapeutic preparation. Methods: Severe peritonitis (SP) model was induced by intraperitoneal injection of E. coli and B. frag, and mild peritonitis (MP) model was induced by cecal ligation and punching. Then the following experiments were done: (1) Survival rates of animals after every 6 hrs in the 72 hrs after modeling were recorded, serum and PLF levels of cytokines, including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ),and interleukin-10 (IL-10), 6 hrs, 12 hrs, 24 hrs and 48 hrs after modeling were measured. (2) Model rats were treated with rlL-12 or SMI, the survival rate was recorded and serum levels of TNF-α, INF-γ, and IL-10before and after treatment were measured, and (3) amount of these cytokines produced by SM were determined 6 hrs, 12 hrs and 24 hrs after treatment. The survival rates and levels of cytokines were then compared between the groups (model group treated with rlL-12 or SMI, untreated model group, and blank group). Results: Serum and PLF levels of IFN-γ, TNF-α at all the time points in SP rats were significantly lower than those in MP rats while those of IL-10 6 hrs and 12 hrs after modeling were significantly higher in the former than that in the latter ( P＜0.05). IFN-γ secretion of SM in SP rats was significantly higher than that in MP rats 6 hrs after modeling (P＜0.05). Administration of rlL-12 or SMI given before modeling could improve the survival rate of the model rats (P＜0.05) and cause significant increase of the serum level and SM secretion of IFN-γ. Conclusion: Imbalance in promoting/antagonizing inflammatory cytokines and Th2 response dominance appear in SP rats early at the initiating stage, and SM secretion of inflammation promoting factor also reduces. Administration in time of rlL-12 and SMI, may increase the survival rate, and its mechanism may be related with their immuno-stimulating action.