云南省居民饮用水氟含量调查

目的了解云南省居民生活饮用水氟含量分布及高氟暴露情况,为政府决策及制定防治措施提供科学依据。方法通过分层抽样,在云南省25个县所有乡(镇)及所有行政村居民主要生活饮用水中抽取1份末梢水样,按照《生活饮用水标准检验方法》GB/T 5705.5-2006,采用离子色谱法检测氟含量,以水氟含量超过1.2 mg/L判定为不合格。结果25个县共检测水样3 884份,中位数为0.069 mg/L(0.000～15.260 mg/L),7份水样水氟含量超标,水氟含量≤0.25 mg/L的村占比以滇西最高(98.27%)、滇北次之(97.82%)、滇南最低(85.93%),水氟含量各县不全相同(H=767.32)、地表水高于地下水(H=1 498 317.00)、流行区高于非流行区(H=316 809.50),差异有统计学意义(均P0.001);水氟含量分散式供水与小型集中供水差异无统计学意义(H=1 523 279.50,P0.05)。结论云南省绝大部分居民生活饮用水水氟含量符合国家标准,大部分地区水氟含量过低且呈片状分布,部分地区高氟水呈局部点状分布,高氟暴露风险较小。     

Guided transcatheter valvulotomy in pulmonary atresia with intact ventricular septum

Transcatheter valvulotomy in pulmonary atresia with an intact ventricular septum can be used as a first step to create biventricular circulation and to stimulate further development of the hypoplastic right ventricle. We describe our experience in a case of a neonate with this congenital cardiac defect who underwent successful transcatheter perforation of the atretic pulmonary valve. This report highlights the utility of a special technique based on the use of a gooseneck snare positioned just above the atretic valve to guide the advance of a coronary guidewire. Other therapeutic alternatives are considered.     

Conditioning regimens in autologous stem cell transplantation for multiple myeloma: a comparative study of efficacy and toxicity from the Spanish Registry for Transplantation in Multiple Myeloma

High-dose chemoradiotherapy conditioning regimens for autologous stem cell transplantation (ASCT) are generally held to give similar results in multiple myeloma (MM), but no specific comparative study has been published. We addressed this issue by comparing the main high-dose chemoradiotherapy regimens used in the Spanish Registry. Patient cohorts included 315 cases treated with 200 mg/m2 melphalan (MEL200), 127 patients with 140 mg/m2 melphalan plus total body irradiation (MEL140 + TBI) and 121 cases with 12 mg/kg busulphan plus 140 mg/m2 melphalan (BUMEL). After ASCT, granulocyte and platelet recovery time was similar in all conditioning groups. There were no differences in transplant-related mortality. All regimens yielded a similar response in reference to pre-ASCT MM status, although BUMEL produced a slightly better overall response when compared with the other regimens (97% vs. 89% and 92%, P = 0.003). The 5-year overall survival (OS) with BUMEL was 47% [95% confidence interval (CI) 26-68] compared with 43% (CI 31-54) for MEL140 + TBI and 37% (CI: 18-56) for MEL200. The median survival for the BUMEL group was 64 months compared with 45 and 37 months for the MEL200 and MEL140 + TBI groups respectively. These differences were non-significant (P = 0.2). The median event-free survival (EFS) was better for BUMEL (32 months) than for MEL200 (22 months) or for MEL140 + TBI (20 months). The differences in EFS between BUMEL and the other conditioning regimens reached statistical significance (P = 0.01). Nevertheless, the adjusted multivariate analysis for OS and EFS revealed that the conditioning regimens had no independent prognostic value. We concluded that three different conditioning regimens, commonly used for ASCT in MM, have a similar antimyeloma effect. However, the trend for better results observed in our series with BUMEL requires a prospective trial.     

Esophageal stenosis in eosinophilic esophagitis

Eosinophilic esophagitis is a rare, recently discovered disease, characterized by esophageal symptoms, such as dysphagia and food impaction, associated with dense eosinophilia on endoscopic biopsy of the esophagus. Other entities such as gastroesophageal reflux disease are absent and there is a lack of response to proton pump inhibitor therapy. This disease mainly affects the pediatric population but is becoming more prevalent in adults. There are several theories on the etiopathogenesis of this entity, which may involve allergies and atopy. In advanced disease, complications such as esophageal stenosis can appear. Treatment is based on dietary elimination, corticosteroids and endoscopic dilatation. We report a case of eosinophilic esophagitis with esophageal stenosis.     

静脉注射小剂量氯胺酮抑制芬太尼所致咳嗽反应临床研究

全麻下行择期手术患者40例随机分为两组,观察组静注氯胺酮0.15 mg/kg,对照组静注同等体积的0.9%生理盐水,10s注射完毕,1min后,静注芬太尼2～3 μg/kg,5 s注射完毕.记录患者咳嗽次数及强度变化.发现静注芬太尼后,观察组发生咳嗽频率明显低于对照组,发生咳嗽的时间较对照组延长.认为预先注射小剂量氯胺酮可有效降低麻醉诱导期间芬太尼所致咳嗽的发生率.     

Progression of renal insufficiency in the pre-end-stage renal disease setting

The rate of decline of renal function (RDRF) in the pre-end stage renal disease setting (pre-ESRD) is highly variable. Several factors have been involved as potential modifiers of renal failure progression. This retrospective study attempts to establish which were the main determinants of the RDRF in pre-ESRD patients followed in the predialysis consult. The study group consisted of 230 patients with pre-ESRD not yet on dialysis who were referred to the predialysis consult from January 1998 to July 2002. The mean follow-up time per patient was 356 days. RDRF was assessed as delta of the average of creatinine and urea clearances (CrCl-UCl). Data obtained at time of referral to the predialysis consult were analyzed as potential predictors of the subsequent RDRF. These independent variables included: demographics, comorbid conditions, main hematological and biochemical data, antihypertensive and statin treatment, mean blood pressure, and CrCl-UCl at time of referral. The predictors of delta CrCl-UCl were determined by multiple linear regression analysis. The determinants of the survival without dialysis were established by the Cox regression hazard model, adjusted to renal function at time of referral. Mean CrCl-UCl at time of referral was 10.98 +/- 2.58 ml/min/1.73 m2, and mean delta CrCl-UCl was -0.37 +/- 0.46 ml/min/1.73 m2/month. Patients with diabetic nephropathy and chronic glomerulonephritis had the fastest RDRF, while patients with ischemic nephropathy and chronic interstitial nephritis had the slowest RDRF. Seventy-five patients (46%) required EPO therapy. The best determinants of delta CrCl-UCl were: the 24-hour proteinuria (p < 0.0001), and the hematocrit at time of referral (p = 0.0024). The best determinants of the survival rate without dialysis during the study period were: the proteinuria (in g/24 hours) (R 1, 16; p < 0.0001), the hematocrit at time of referral (OR: 0.88; p < 0.0001), the treatment with EPO (OR: 0.59; p = 0.02), and the diagnosis of diabetes mellitus (OR: 1.59; p = 0.01). In conclusion, apart from the rate of proteinuria, which could represent the best marker of the RDRF in chronic renal diseases, the development of anemia was associated with faster decline in renal function.     

Arthroplasty in congenital aortic coarctation in adults with balloon and endovascular prosthesis: immediate results and 6-month follow-up

Up to 1982, surgery was the treatment of aortic coarctation, with postsurgical recoarctation in 39% of cases. Since 1984 balloon aortoplasty has been performed successfully in adolescents and adult patients. We present the immediate results, and more than six months follow up of 6 patients with congenital aortic coarctation, who underwent this procedure. Five of the six patients were male, with an average age of 28.6 years (15-46), and in 4 of them a stent was placed. Systolic pressure of ascending aorta decreased from 187.1 mm of Hg (+/- 41.8) to 128 (+/- 25.4), and transaortic gradient from 66 mm of Hg (+/- 21.8) to 4.8 (+/- 7.6). Coarctation luminal diameter increased from 4.6 mm (+/- 1.41) to 14.3 (+/- 3) in patients with only balloon aortoplasty and to 17.8 mm with stent placement, p = NS. Angiography in three patients with stent at 6 months did not reveal restenosis, all six patients require less antihypertensive medications. Acute and chronic complications, percentage and time of restenosis, long term results, and possible benefit of stents are yet to be determined.