外源性一氧化氮治疗胎儿急性宫内窘迫

对13例胎儿急性宫内窘迫者行胎儿电子监护。于第一产程活跃期后或第二产程取胎儿头皮血及产妇动脉血行血气分析。产妇舌下含服硝酸甘油片0.5mg,15～30min后再次取胎儿头皮血及产妇动脉血行血气分析。结果:(1)用药后异常胎心率恢复正常;(2)用药后胎儿头皮血pH提高,二氧化碳分压降低,血氧饱和度升高,用药前、后差异显著;(3)13例中7例由失代偿型代谢性酸中毒转变为代偿形代谢性酸中毒;(4)产妇用药后血液酸碱代谢无明显改变。结论:硝酸甘油在体内可提供一氧化氮,它能扩张胎盘的血循环,增加胎儿供氧,改善胎儿酸中毒状态。     

15例老年人肺炎误诊分析

老年人由于免疫功能低下,各种器官系统相应发生老化,发生炎症时表现不明显,导致肺炎症状及体征不典型,以致误诊。现收集近年来被误诊为其他疾患的老年人肺炎15例分析如下。     

DNA content and morphological parameters in synovial sarcoma and synovioma.

By using image analysis technique with 6 normal synovial tissue specimens as controls,nuclear DNA content and morphological parameters in specimens from 51 synovial sarcomas and 15 synovioma were examined quantitatively.The DNA content in synovial sarcoma and synovioma was significantly different (P<0.01), and that of synovioma and normal synovial tissue was also different (P<0.05).Morphological parameters including nuclear areas and perimeters differed significantly among the above three groups(P<0.01).There was no correlation between the DNA content of synovial sarcoma and its histologic type (P>0.05), but the DNA content greatly differed between its higher and lower differentiated grade in each type (P<0.01). The DNA content in synoviai sarcoma IIA stage, according to Enneking's staging system, was lower than that in ⅡB, ⅢA and ⅢB (P<0.05).The 5-year survival rate of synovial sarcoma with diploid/nearly diploid (D/ND) pattern was higher than that of aneuploid (AN) pattern (P=0.028). The study suggests that analysis of the DNA content and morphological parameters of tumor cells is helpful in the diagnosis and pathologic grading of synovial sarcoma.It also provides a guide to clinical operation and estimation of the prognosis. Although synovioma is usually a well-differentiated and benign lesion,this investigation also suggested that increased DNA content may be an indication of poor prognosis for this neoplasm.     

维生素 D_3对大鼠的免疫调节作用研究

观察多次注射维生素 D_3对大鼠的免疫调节作用,结果证明维生素 D_3对抗体产生有双相调节作用,并可增强单核巨噬细胞的分泌功能。连续使用大剂量维生素 D_3可使 T 细胞数量减少。     

人参皂甙单体Rb1对大鼠在体心脏收缩性能的影响

本文作者为进一步探讨人参皂甙单体Rb1对心肌收缩的影响,完善人参对心肌保护作用的系统性研究,拟在在体工作鼠心上,以心肌收缩性能为指标,对比观察Rb1对心肌收缩的影响.     

宫颈鳞癌和食管鳞癌中Fas基因表达及其与放射敏感性的关系

用免疫组化法对 52例宫颈鳞癌和食管鳞癌标本中 Fas基因蛋白进行研究 ,并探讨其与近期放疗效果的关系。结果显示 ,Fas蛋白在宫颈鳞癌和食管鳞癌中表达分别为48.3 8%和 61 .90 % ,Fas蛋白在高分化癌中表达率高于低分化者 ( P<0 .0 5) ,与病期无关 ( P>0 .0 5)。在宫颈鳞癌中 ,Fas蛋白表达高者放疗效果较好 ( P<0 .0 5) ,食管鳞癌 Fas表达与放疗效果无明显相关 ,提示 Fas表达与放射敏感性有一定关系 ,对放疗预后判断有一定价值