阿仑膦酸钠对2型糖尿病骨质疏松患者的临床疗效分析

目的:探究阿仑膦酸钠对2型糖尿病骨质疏松患者的临床疗效.方法:抽选我院近一年来收治的90例2型糖尿病骨质疏松患者作为研究对象,按入院先后顺序将其等分为对照组和实验组,对照组采用常规治疗,实验组采用阿仑膦酸钠治疗,对比两组的骨密度指标及骨代谢生化指标,采用《疼痛数字评价量表》(Numerical Rating Scale...     

高渗氯化钠羟乙基淀粉40注射液高容量血液稀释对大鼠肝脏缺血再灌注损伤的影响

Objective To investigate the effects of hypervolemic hemodilution (HH) with hypertonic saline plus hetastarch solution 40 injectio on hepatic ischemia-reperfusion (I/R) injury in rats. Methods Thirty male Wistar rats weighing 300-350 g were randomly divided into 3 groups ( n = 10 each): group I sham operation (group S); group II I/R and group Ⅲ HH. Partial liver ischemia was produced by clamping hepatic portal vein and left arteria hepatica for 30 min with atraumatic mini-clamp, followed by 2 h of reperfusion in I/R group and HH group. In HH group the animals were infused hypertonic saline plus hetastarch solution 40 injectio 10 ml/kg through vena caudalis over 30 min and then hepatic I/R was performed IS min after the infusion.The animals were killed at 2 h of reperfusion. The left liver was removed and blood sample was taken from inferior caval vein for determination of (1) serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activities; (2) superoxide dismutase ( SOD) activity and malondialdehyde ( MDA) content in the liver; ( 3 ) microscopic examination. Results The serum ALT and AST activities and MDA content in the liver were significantly higher, SOD activity in the liver significantly lower after hepatic I/R and pathological changes in the liver severer in group I/R and HH than in group S. The serum ALT and AST activities and MDA content in the liver were significantly lower, SOD activity in the liver significantly higher after hepatic I/R and pathological changes in the liver milder in group HH than in group I/R. Conclusion Hypervolemic hemodilution with hypertonic saline plus hetastarch solution 40 injectio can ameliorate hepatic I/R injury by decreasing oxygen free radical production in rats.     

基于铁死亡基因的口腔鳞癌预后模型开发和验证

目的:探究铁死亡相关基因(FRGs)在口腔鳞状细胞癌(OSCC)中的预后价值并构建预后模型。方法:从癌症基因组图谱(TCGA)数据库下载OSCC患者的RNA-seq和临床数据,利用生物信息学方法筛选差异表达FRGs,从而构建预后模型并对其准确性进行验证,使用基因综合表达(GEO)数据库的独立队列做外部验证。结果:预后模型包括3个FRGs,与其他临床指标相比基于该模型的风险评分是一个更好的预后指标,可以作为OSCC的独立预后因素,并且模型的准确性在GEO的数据集中得到了验证。结论:本研究成功构建了一个FRGs模型,该模型可用于预测OSCC患者预后,为铁死亡在OSCC临床预后中的研究提供参考。     

儿童胫骨近端三平面骨骺骨折一例报告

胫骨近端骨骺骨折在儿童中是一种不常见的损伤,仅占儿童骨骺损伤的 1％ 以下 [1].其中,胫骨近端的三平面骨骺骨折更为少见.胫骨近端三平面骨折发生在三个平面:横面、矢状面和冠状面,多见于青春期,横穿关节面、骨骺、骺板和干骺端.在临床资料中,国内尚未见此类报道.笔者报道 1 例儿童胫骨近端三平面骨骺分离,其膝关节正侧位 ...     

嗜铬细胞瘤麻醉处理1例

1临床资料 患者,女性,64岁,因“偶发性头晕2年余,体检发现右肾上腺占位病变1周”入院。入院诊断为：嗜铬细胞瘤（右）。拟于全麻下行右侧嗜铬细胞瘤切除术。     

浅谈淋证的辩证施护

浅谈淋证的辩证施护赵金荣，吕浩淋证在临床中多见，以小便频急，淋漓不尽，尿道涩痛，小便拘急，痛引脐中为特征。多因肾虚、膀胱湿热，气化失司，水道不利所致。属于现代医学的泌尿系感染、结石、结核、前列腺炎多见。除有淋证的基本特征外，尚有各自不同的临床表现。故...     

几种雌激素衍生物的抗辐射作用

不少工作证明雌激素对受照射动物具有保护作用。为了取得抗放效价更高的雌激素,近年来,四川化学研究所合成了一系列雌激素衍生物,我们对其中的18种合成药物,进行了抗辐射效果的筛选,发现12种药     

关节镜下跟骨骨刺切除联合足底跖筋膜松解术治疗足跟痛的临床疗效

目的探讨关节镜下跟骨骨刺切除联合足底跖筋膜松解术治疗足跟痛的可行性及疗效。方法回顾性分析2015年1月至2017年12月43例跟骨刺疼痛患者的临床资料,所有患者均行关节镜下疼痛跟骨刺切除联合足底筋膜松解术,术后随访6～12个月。除常规足部检查外,采用VAS评分系统评估足部的疼痛程度。采用AOFAS-AH评分系统对足痛、自主活动、步态和稳定性进行综合评价。结果 VAS评分由术前的(8. 71±1. 64)分降为术后6个月的(6. 28±2. 44)分,差异具有统计学意义(P 0. 05)。AOFAS-AH评分从术前的(56. 43±3. 72)分增加至术后6个月的(94. 51±2. 93)分,差异具有统计学意义(P 0. 05)。结论关节镜下跟骨骨刺切除联合足底跖筋膜松解术治疗足跟痛术后疼痛缓解快、足部功能恢复快,微创手术效果满意,具有较大的临床可行性和优越性。     

6%羟乙基淀粉130/0.4对患者硬膜外复合全麻诱导期肺循环的影响

Objective To observe the effect of pulmonary circulation by 6% hydroxyethyl starch 130/0.4 during induction period from epidural block combined with general anesthesia. Methods Twenty-six hepatobiliary surgical patients with ASA Ⅰ-Ⅱ, aged 32 y-59 y, weighing 54 kg-73 kg, were randomized into 2 groups(n=13): hydroxyethyl starch 130/0.4 group(HS)and complex acetic acid Ringer's solution (RL). Above-mentioned solutions were infused 7 ml/kg respectively before induction. The pulmonary circulation hemodynamic parameters such as pulmonary arterial systolic pressure (PASP), pulmonary arterial diastolic pressure (PADP), mean pulmonary artery pressure(MPAP), pulmonary artery wedge pressure(PAWP), pulmonary vascular resistance(PVR) and right ventricular stroke work(RVSW) were recorded at base value(T0), 10 min after infusion(T1), 5 min after induction(T2), 5 rain after intubation(T3), 10 rain after intubation(T4)and 20 min after intubation(T5). Results PASP、PADP、MPAP、PAWP and CVP were significantly higher in group HS at T, than the values at T0 (P<0.05); PVR in group HS was obviously lower from T1 to T5 than the value at To (P<0.05 or P<0.01); RVSW was significantly higher in two groups at T1 than base value (P<0.05), but that in group HS was lower than base value (P<0.05 or P<0.01); HR obviously decreased in two groups from T2 to T5 as compared with the value at T0 (P<0.05); MAP was lower from T3 to T5 than the value at To (P<0.05 or P<0.01). PVR was obviously lower in group HS from T1 to T5 than that in group RL (P<0.05 or P<0.01); MAP obviously increased from T2 to T5 in group HS as compared with the value in group RL(P<0.05 or P<0.01). Conclusion 6% hydroxyethyl starch 130/0.4 can obviously reduce PVR during induction pe-riod from epidural block combined with general anesthesia. In all, there is no effect on pulmonary circulation by 6% hydroxyethyl starch 130/0.4.     

基于混合遗传算法的多信道经颅磁刺激线圈阵列设计与优化

目的 探讨多信道经颅磁刺激技术的实现方式,以实现对具有多点同时刺激、刺激点可移动等优点的磁刺激技术的模拟仿真.方法 分析圆形线圈感应电场分布规律,设计并建立了一种2×5×5的交叉型线圈阵列模型;针对优化问题设计了结合模式搜索的混合遗传算法,对交叉型线圈阵列的电流组态进行了优化.结果 给出了两点刺激和三点刺激的优化结果,结果表明这种混合遗传算法具有很好的全局和局部搜索特性,在优化算法的优化下,交叉型线圈阵列可以有效逼近指定的感应电场分布.结论 本文设计的线圈阵列结构和优化算法实现了经颅磁刺激中的多点刺激和刺激点移动问题,对于多信道经颅磁刺激的实现具有一定的参考借鉴意义.