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高超 《国外畜牧学(草食家畜)》1995,(2)
灌服浓盐水配合注射硫酸钠液治疗牛瓣胃阻塞效果好高超(山东畜牧兽医学校)牛瓣胃阻塞(又称百叶干)是较为严重的前胃疾病之一。多因冬春两季长期吃单一的质量较差的粗纤维饲料,加以初春天气干燥及饮水不足.致使前胃运动机能减弱,食物在瓣胃内停滞、变干而引起。瓣胃... 相似文献
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Objective To identify the HLA-A2-restricted CTL epitopes encoded by antigen segment of Ki-67 for preparation of tumor vaccines. Methods Two epitope prediction databases ( BIMAS and SYFPEITHI) were used to predict the epitopes of Ki-67, and 7 peptides were synthesized as the candi-dates. The prediction was evaluated by peptide-binding test. ELISPOT was used to inspect the IFN-γ secre-ted by CTLs in order to reflect the immunogenicity of the peptides. Results The purities of synthetic pep-tides and positive control peptide were all above 95%. Peptide-binding test displayed that LQGETQLLV (280-288) of Ki-67 could bind with HLA-A2 molecule more strongly. ELISPOT assay displayed that LQGETQLLV could induce activation of specific CTLs. Conclusion LQGETQLLV (280-288) might be the HLA-A2-restricted CTL epitope of Ki-67 antigen. 相似文献
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20世纪80年代以来,国外有关精神分裂症与细胞因子的相关性研究表明,精神分裂症患者存在多种细胞因子功能异常,但对于抗精神病药物对细胞因子的影响研究较少。本研究旨在探讨利培酮对精神分裂症患者血清白介素6(IL-6)、白介素8(IL-8)、r干扰素(IFN-γ)和肿瘤坏死因子α(TNF—α)的影响,并探讨精神症状、药物副作用与细胞因子的关系。 相似文献
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Objective To identify the HLA-A2-restricted CTL epitopes encoded by antigen segment of Ki-67 for preparation of tumor vaccines. Methods Two epitope prediction databases ( BIMAS and SYFPEITHI) were used to predict the epitopes of Ki-67, and 7 peptides were synthesized as the candi-dates. The prediction was evaluated by peptide-binding test. ELISPOT was used to inspect the IFN-γ secre-ted by CTLs in order to reflect the immunogenicity of the peptides. Results The purities of synthetic pep-tides and positive control peptide were all above 95%. Peptide-binding test displayed that LQGETQLLV (280-288) of Ki-67 could bind with HLA-A2 molecule more strongly. ELISPOT assay displayed that LQGETQLLV could induce activation of specific CTLs. Conclusion LQGETQLLV (280-288) might be the HLA-A2-restricted CTL epitope of Ki-67 antigen. 相似文献
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Objective To investigate the antitumor effect of oncolytic adenovirus armed with small interference RNA targeting hTERT gene for renal cancer therapy. Methods Nude mice were divid-ed randomly into 4 groups (8 mice/group),and were treated by intratumoral injections of ZD55-hTERT ( an oncolytic adenovirus armed with small interference RNA targeting hTERT gene) ,ZD55-EGFP ( an on-colytic adenovirus) and Ad-hTERT (replication-defective adenovirus armed with small interference RNA targeting hTERT gene) with three consecutive daily at 7 × 108 pfu/day or treated with PBS as a control. The expression of E1A and hTERT, and apoptosis of tumor xenografts were assessed by immunohistochemi-cal technique at the 7th day after injections. The tumor volume was measured at the 50th day after injec-tions. Results The tumor volume in ZD55-hTERT treatment group ( 124.1±27.5) was significantly less than that in ZD-EGFP (499.8±77.1 ) and Ad-hTERT ( 609.0±102.5 ) treatment groups. The E 1A pos-itive expression in ZD55-hTERT treatment group was significantly higher than that in Ad-hTERT treatment group. The hTERT positive expression in ZD55-hTERT treatment group was significantly lower than that in Ad-hTERT treatment group. ZD55-hTERT treatment of tumor xenografts resulted in an increased apoptotie cell death as compared with ZD55-EGFP and Ad-hTERT treatment. Conclusion The antitumor effect of ZD55-hTERT was more potent than oneolytie adenovirus ZD55-EGFP and Ad-hTERT. 相似文献
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内皮抑素及其基因治疗肿瘤的新进展 总被引:1,自引:0,他引:1
1971年Folkman教授首次提出“肿瘤的生长依赖于血管生成 ,新血管的形成是体积 >1~ 2mm3 实体瘤生长和癌细胞转移的前提条件”。从此抑制肿瘤血管的生成成为肿瘤治疗学研究的新热点。 1997年O’Reilly[1] 首次从鼠的血管内皮细胞瘤 (Eoma)培养液中提取出内皮抑素———一种新的血管生成抑制因子。经过 5年的实验动物研究和Ⅰ期临床试验证明 :内皮抑素能有效抑制血管内皮的增殖 ,促使肿瘤细胞的凋亡 ,抑制肿瘤的生长和转移 ,具有很强的抗肿瘤特性 ,而且无耐药性和毒副作用[1] 。本文就内皮抑素及其基因治疗肿瘤的研究应… 相似文献