WNT信号传导途径在造血干细胞自我更新中的作用

WNT信号传导途径作为传递生长刺激信号的通路,对于动物的胚胎发育和形态学发生至关重要,但在成年动物中则会导致肿瘤的发生和生长。近来研究显示WNT途径在造血干细胞(HSC)的自我更新中发挥重要作用,并参与一些血液系统恶性疾病如白血病的发病。     

辅舒酮加万托林吸入治疗毛细支气管炎39例疗效观察

呼吸道感染性疾病是儿童发病率最高的疾病 ,其中毛细支气管炎是 2岁以内婴幼儿冬春季较常见疾病。我们采用吸入辅舒酮、万托林佐治毛细支气管炎取得较好疗效 ,现报告如下。1　对象和方法1.1　对象　我院自 2 0 0 2 - 10～ 2 0 0 3- 0 3收治住院的毛细支气管炎 82例 ,诊断标准参照《实用儿科学》[1 ] (除外先心病、佝偻病、营养不良及并呼衰、心衰及其他脏器功能衰竭患儿 )。简单随机化分为治疗组 39例 ,男 2 1例 ,女 18例 ;对照组 4 3例 ,男 2 3例 ,女 2 0例。两组年龄均为 2～ 18月龄 ,入院均有咳嗽、喘憋、肺部满布哮鸣音及细湿罗音。两组…     

导航下与传统方法应用动力髋螺钉治疗老年股骨转子间骨折的疗效比较

Objective To compare the navigational and traditional dynamic hip screw (DHS) fix-ations in the treatment of intertrochanteric fractures in elderly patients. Methods A retrospective study was conducted to analyze the elderly patients with intertrochanterie fracture who had been treated in our de-partment from April 2005 to April 2007 and whose clinical data were complete. Enrolled in the present study were 25 cases that had received navigational DHS fixation and 31 cases who had received traditional DHS fixation. In navigational group, there were 10 males and 15 females, with an average age of 82. 1 years. They were 14 eases of Evans type Ⅰ and 11 Evans type Ⅱ. In traditional group, there were 12 males and 19 fe-males, with an average age of 82. 8 years. They were 16 cases of Evans type Ⅰ and 15 Evans type Ⅱ. The 2 groups were compared in incision length, operation time, bleeding volume, X-ray exposure time, bed-ridden time, medical and implant complications, and one-year functional recovery. Results In navigational group, 23 patients were followed for 11 to 20 (average, 14) months and 2 were lost. In traditional group, 30 patients were followed up for 14 to 23 (average, 18) months and 1 died from cardiovascular disease within 1 year. Compared with traditional group, navigational group had a smaller incision, less blood loss, shorter bed-ridden time and less X-ray exposure time, a higher rate of fracture healing at 3 months, with statistically significant differences (P <0.05). The Harris hip function scores at postoperative 1 year were of no significant difference between the 2 groups (P > 0.05) . In navigational group there were 3 medical and 1 implant complications. In traditional group there were 9 medical and 5 implant complications. There was no significant difference between the 2 groups (P > 0.05). Conclusion In the treatment of intertrochanteric fractures for the elderly patients, the navigational DHS fixation is superior to traditional DHS fixation due to its ad-vantages of smaller incision, less blood loss, shorter bed-ridden time, faster fracture healing and betterfunctional recovery.     

隆德县食品中有机氯农药残留量调查

有机氯农药在我国是使用最广的杀虫剂之一,这类农药的主要特点是杀虫范围广,其化学性质稳定,挥发性低,不易分解,残留期长,脂溶性高,水溶性低等。在长期大量使用过程中,易     

关于动态合力曲线的初步分析研究

我们采用应变传感器式力测定仪加以改进，并与动态电阻应变仪及紫外光线示波器联接，记录措力及胎力曲保，建立动态力曲线测试系统，并利用该系统对３９名正常受试者第一恒磨牙最大力及力变化情况进行测定及分析研究。验征了正常左右侧力的对称性，对一些影响因素进行了讨论，为临床的进一步研究提供了依据和参考，对病理状态下的力变化的进一步深入研究打下了基础。     

小金钱草的生药鉴别研究

本文对江西地方习用药材小金钱草作了药材性状及显微鉴别的研究，认为其可作为该品种鉴定的参考。     

以雌激素受体α为靶点抗胃腺癌黄酮类物质的筛选

目的 筛选与雌激素受体（ER）α结合力最好的中药成分并验证其抗胃腺癌效果。方法 通过生物信息学比较雌激素受体基因与胃腺癌中的相关性并评估雌激素受体1基因表达量与胃腺癌患者预后的关系。借助分子对接对比20种中药成分与ER-α结合性能,采用噻唑兰（MTT）实验验证甘草素抗胃腺癌效果并通过抗体封堵实验验证甘草素的作用靶标蛋白。结果 ESR1在肿瘤组织比正常组织中表达低,是影响患者首次进展生存期的独立因素。20种黄酮类物质中与ER-α对接能力最好的为甘草素。与空白对照相比,300μmol/L、500μmol/L、1 000μmol/L甘草素组胃癌细胞抑制率均升高[分别为18.0±4.8、16.9±2.5、54.1±4.7;均P<0.05],甘草素+ER抗体组与甘草素组相比,胃癌细胞抑制率降低[分别为31.3±0.7、46.2±0.3; P<0.05]。结论 甘草素与ER-α对接能力最强,可激活ER-α抑制胃腺癌进展,有望成为胃腺癌治疗的新药物。     

膝关节功能障碍34例康复护理体会

2003年6月～2005年12月,我们采用综合康复治疗措施治疗膝关节功能障碍患者34例,经精心护理,效果满意。现将护理体会报告如下。1资料与方法1.1临床资料本组34例,男23例,女11例,平均35.2±4.3岁。病程2.58±1.73个月,关节活动度29.87°±11.84°,股骨中段骨折7例,股骨下段骨折6例,踝骨骨折4例,膑骨骨折8例,半月板切除术后4例,膝关节骨膜炎2例,关节腔积液2例,其他损伤1例。患者均为膝关节屈曲受限,均有不同程度的股四头肌萎缩。1.2治疗方法①感应电疗法:1000Hz感应电流刺激感觉神经末梢,帮助恢复知觉,解除表皮的神经性疼痛。超短波电疗1次/d,1…     

脑小血管病脑白质损伤动物模型

脑小血管病是导致认知功能减退、步态情感障碍和痴呆的重要脑血管疾病,脑白质弥漫 性损伤是该病的重要影像学特征。结合国内外近年来相关研究内容,本文对不同的脑小血管病白质 损伤动物模型制作进行了系统性回顾,包括单一型动物模型如双侧颈总动脉狭窄模型、脑淀粉样血 管病模型、Notch3 转基因小鼠模型、自发性高血压大鼠模型、易卒中型肾血管性高血压大鼠模型,以 及由两个或两个以上单一型动物模型组合而成的复合型动物模型等。     

预防呼吸机相关性肺炎的研究进展

综述了预防呼吸机相关性肺炎（VAP）的研究进展,主要内容包括：发生VAP的主要因素、预防措施等。认为VAP的发生是多种因素共同导致的结果,只有针对VAP的危险因素制定综合防治措施,才是防治VAP发生的最佳策略。