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71.
[目的]观察爱可欣^TM敷料应用于包皮环切术切口护理的效果。[方法]将78例包皮环切手术病人随机分成观察组与对照组,观察组病人用爱可欣^TM敷料护理手术切口,对照组病人用传统的方法即凡士林纱布护理手术切口。术后随访8d,观察术后第1天、第2天、第3天切口疼痛情况及切口愈合情况。[结果]观察组病人术后第1天、第2天、第3天疼痛明显低于对照组,观察组切口愈合时间比对照组明显缩短,甲级愈合率高于对照组。[结论]用爱可欣^TM敷料护理包皮环切手术切口,能有效地缓解手术切口疼痛,促进切口愈合。 相似文献
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73.
目的评价回生口服液对中晚期非小细胞肺癌(NSCLC)患者化疗后血凝状态及疗效的影响。方法将69例首次确诊且可接受化疗的中晚期NSCLC随机分为实验组35例和对照组34例,两组皆采用含铂三代一线方案(吉西他滨+顺铂,或多烯紫杉醇+顺铂)化疗,21天为一周期。其中实验组在化疗同时配合使用回生口服液,10毫升/次,3次/日,从化疗当天开始口服,全程使用直至化疗终止。所有患者至少接受2周期化疗并评价临床客观疗效,在化疗前和第二周期化疗结束后一周检测血小板(PLT)、D-二聚体(D-dimer)、纤维蛋白水平(FIB)。结果实验组总有效率74.3%(26/35),临床受益率(CBR)为80.0%(28/35),疾病进展时间(TTP)为(5.5±2.8)月,平均生存期为(11.1±5.8)月。对照组总有效率47.1%(16/34),CBR为55.9%(20/34),TTP为(4.2±2.5)月,平均生存期为(8.4±5.3)月,两组总有效率、CBR、TTP与平均生存期比较差异均有统计学意义(P<0.05);化疗后实验组PLT(157±89)×109/L、D-dimer(2078±770)μg/ml、FIB(3.8±1.4)g/L,与对照组PLT(208±118)×109/L、D-dimer(2680±980) μg/ml、FIB(4.6±1.8)g/L比较差异均有统计学意义(P<0.05、P<0.01、P<0.05),且对照组化疗后有3例(8.8%)发生深静脉血栓,实验组无1例发生。结论回生口服液配合化疗提高了NSCLC患者近期疗效,并在一定程度上改善了血液高凝状态,可预防深静脉血栓的发生,并能延长TTP和平均生存期,值得临床推广。 相似文献
74.
塞来昔布对人鼻咽癌CNE-2细胞生长抑制及放射增敏研究 总被引:1,自引:0,他引:1
Objective To investigate the growth inhibition and radiosensitization of Celecoxib in hu-man nasopharyngeal carcinoma cell line CNE-2. Methods CNE-2 growth inhibition by Celecoxib was eval-uated by MTT method. Apoptosis-related changes in morphology were observed by transmission electron mi-croscopy (TEM). Cell cycle distribution and apoptosis rate were measured by flowcytometry (FCM). The ex-pression of COX-2 protein was observed by SP method after the treatment of Celecoxib. Cells were randomly planted into four groups: irradiation control(Ci), drug group(Cd), irradiation group(R), and Celecoxib plus irradiation group(D+R). Single irradiation of 2,4,6,8,and 10 Gy were administered for colonogenic assay. Cell cycle distribution and apoptosis rate were analyzed at 6 Gy irradiation. Results The growth of CNE-2 cell was inhibited by celecoxib in a dose-and time-dependent manner, the IC50 was 80 μmol/L After the treatment, cell ratio of GO and G, phases was increased (47.03±2.76 vs 56.17±1.95, t=4.68, P= 0.010), whereas the ratio of S and G2/M phases was decreased (33.07±1.86 vs 24.87±1.76, t=5.54, P = 0.010; 19.30±0.53: 17.73±0.83, t=2.75, P=0.050), and the apoptosis rate was increased (1.57±0.47:10.47±0.31, t = 27.39, P = 0.000) in a dose-dependent manner. Apoptosis with nuclear chromatin condensation, fragmentation and cell shrinkage was found by TEM. SP method showed that Celeib decreased COX-2 expression (17.48±0.34 vs 12.82±0.51,t=13.20,P =0.00). The sensitivity ratio(D0) was 1.15. FCM showed that the percentage of cells in G2/M phase was significanty more in R and D+R groups than in Ci and Cd groups (68.00±1.65,54.27±5.74,17.60±0.80,14.86±1.23, t=47.70,P=0.000; t=11.63, P=0.000), and also significantly different between R group and D + R group (t=3.99, P= 0.020). The apoptosis rate was higher in R and D + R groups than Ci and Cd groups(4.83±0.97,9.50± 1.35,1.33±0.86 and 2.28±0.42,t=4.67,P=0.010;t=8.81, P=0.000), D + R group than R group(t =4.85,P=0.010). Conclusions Celecoxib can markedly inhibit the growth and induce apoptosis in CNE-2 cells,which may depend on COX-2 pathway. Celeeoxib potently enhances the radiosensitivity of CNE-2 cells,which may due to the repair inhibit of radiation-induced DNA damage, inhibit of cell proliferation,and enhancement of cell apoptosis after irradiation. 相似文献
75.
Objective To investigate the growth inhibition and radiosensitization of Celecoxib in hu-man nasopharyngeal carcinoma cell line CNE-2. Methods CNE-2 growth inhibition by Celecoxib was eval-uated by MTT method. Apoptosis-related changes in morphology were observed by transmission electron mi-croscopy (TEM). Cell cycle distribution and apoptosis rate were measured by flowcytometry (FCM). The ex-pression of COX-2 protein was observed by SP method after the treatment of Celecoxib. Cells were randomly planted into four groups: irradiation control(Ci), drug group(Cd), irradiation group(R), and Celecoxib plus irradiation group(D+R). Single irradiation of 2,4,6,8,and 10 Gy were administered for colonogenic assay. Cell cycle distribution and apoptosis rate were analyzed at 6 Gy irradiation. Results The growth of CNE-2 cell was inhibited by celecoxib in a dose-and time-dependent manner, the IC50 was 80 μmol/L After the treatment, cell ratio of GO and G, phases was increased (47.03±2.76 vs 56.17±1.95, t=4.68, P= 0.010), whereas the ratio of S and G2/M phases was decreased (33.07±1.86 vs 24.87±1.76, t=5.54, P = 0.010; 19.30±0.53: 17.73±0.83, t=2.75, P=0.050), and the apoptosis rate was increased (1.57±0.47:10.47±0.31, t = 27.39, P = 0.000) in a dose-dependent manner. Apoptosis with nuclear chromatin condensation, fragmentation and cell shrinkage was found by TEM. SP method showed that Celeib decreased COX-2 expression (17.48±0.34 vs 12.82±0.51,t=13.20,P =0.00). The sensitivity ratio(D0) was 1.15. FCM showed that the percentage of cells in G2/M phase was significanty more in R and D+R groups than in Ci and Cd groups (68.00±1.65,54.27±5.74,17.60±0.80,14.86±1.23, t=47.70,P=0.000; t=11.63, P=0.000), and also significantly different between R group and D + R group (t=3.99, P= 0.020). The apoptosis rate was higher in R and D + R groups than Ci and Cd groups(4.83±0.97,9.50± 1.35,1.33±0.86 and 2.28±0.42,t=4.67,P=0.010;t=8.81, P=0.000), D + R group than R group(t =4.85,P=0.010). Conclusions Celecoxib can markedly inhibit the growth and induce apoptosis in CNE-2 cells,which may depend on COX-2 pathway. Celeeoxib potently enhances the radiosensitivity of CNE-2 cells,which may due to the repair inhibit of radiation-induced DNA damage, inhibit of cell proliferation,and enhancement of cell apoptosis after irradiation. 相似文献
76.
目的观察脓肿型、溃疡型淋巴结核切开引流病灶清除,脓腔内利福霉素纱条填塞换药的治疗效果。方法选择受治疗的73例脓肿型、溃疡型淋巴结核患者,在全身抗结核治疗的基础上,采用脓肿切开、脓腔及窦道内病灶清除及利福霉素钠纱条腔内填塞换药的治疗方法,观察患者的治疗效果。结果所有患者术后脓腔在21~45 d内全部愈合,平均愈合时间25.7 d,仅有2例在1年内复发,经再次同样处理后治愈。结论采用脓肿切开引流、病灶清除脓腔内利福霉素钠纱条填塞换药的方法治疗脓肿型、溃疡型淋巴结核效果好。 相似文献
77.
目的评价蜂蜜敷料局部治疗糖尿病足部溃疡的效果。方法抽取外科门诊就诊的糖尿病足溃疡患者105例,随机分为A、B、C三组,每组35例,分别使用自制的蜂蜜敷料、功能敷料和常规敷料治疗,观察三组伤口不同时间点的细菌清除率、面积愈合率及细菌清除时间、清创时间和治疗时间。结果蜂蜜敷料组(A组)的细菌清除率、面积愈合率明显优于B、C组(P<0.05),且细菌清除平均时间、清创时间和治疗时间短于功能敷料和常规敷料B、C组(P<0.05)。结论蜂蜜敷料治疗糖尿病足部溃疡有助于清除伤口感染和坏死组织,促进肉芽生长,有湿性愈合的作用。 相似文献