全文获取类型
收费全文 | 170364篇 |
免费 | 6778篇 |
国内免费 | 312篇 |
专业分类
耳鼻咽喉 | 3062篇 |
儿科学 | 6393篇 |
妇产科学 | 4372篇 |
基础医学 | 24004篇 |
口腔科学 | 4795篇 |
临床医学 | 12724篇 |
内科学 | 31005篇 |
皮肤病学 | 4675篇 |
神经病学 | 15699篇 |
特种医学 | 8777篇 |
外国民族医学 | 24篇 |
外科学 | 28318篇 |
综合类 | 1089篇 |
一般理论 | 37篇 |
预防医学 | 7979篇 |
眼科学 | 4603篇 |
药学 | 11789篇 |
中国医学 | 348篇 |
肿瘤学 | 7761篇 |
出版年
2023年 | 772篇 |
2021年 | 1234篇 |
2020年 | 1107篇 |
2019年 | 1298篇 |
2018年 | 2874篇 |
2017年 | 2366篇 |
2016年 | 3301篇 |
2015年 | 3658篇 |
2014年 | 3871篇 |
2013年 | 5429篇 |
2012年 | 8319篇 |
2011年 | 7716篇 |
2010年 | 4612篇 |
2009年 | 3670篇 |
2008年 | 7656篇 |
2007年 | 8491篇 |
2006年 | 8540篇 |
2005年 | 8934篇 |
2004年 | 8502篇 |
2003年 | 8416篇 |
2002年 | 8303篇 |
2001年 | 6183篇 |
2000年 | 6250篇 |
1999年 | 5407篇 |
1998年 | 1586篇 |
1997年 | 1305篇 |
1996年 | 999篇 |
1995年 | 806篇 |
1994年 | 748篇 |
1992年 | 2393篇 |
1991年 | 2316篇 |
1990年 | 2278篇 |
1989年 | 2125篇 |
1988年 | 1858篇 |
1987年 | 1844篇 |
1986年 | 1708篇 |
1985年 | 1647篇 |
1984年 | 1284篇 |
1983年 | 1023篇 |
1979年 | 1382篇 |
1978年 | 1017篇 |
1977年 | 852篇 |
1975年 | 1088篇 |
1974年 | 1131篇 |
1973年 | 1018篇 |
1972年 | 1033篇 |
1971年 | 1002篇 |
1970年 | 887篇 |
1969年 | 833篇 |
1968年 | 802篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
171.
VGH Bad.-Württ. 《MedR Medizinrecht》2007,25(2):116-119
Abstrakt Nach § 13 Abs. 2 S. 1 BPflV 1995 ist als Entgelt für ?rztliche und pflegerische T?tigkeit und die dadurch veranlassten Leistungen
für jede organisatorisch selbstst?ndige bettenführende Abteilung, die von einem fachlich nicht weisungsgebundenen Arzt mit
entsprechender Fachgebietsbezeichnung geleitet wird, ein Abteilungspflegesatz zu vereinbaren und bei Nichtvereinbarung durch
die Schiedsstelle festzusetzen (§ 18 Abs. 4 KHG).
Der Bildung eines Abteilungspflegesatzes steht nicht entgegen, dass keine dem Leistungsspektrum der Abteilung deckungsgleiche
Facharztbezeichnung existiert, sofern der Leiter der Abteilung über eine Facharztbzw. Fachgebietsbezeichnung verfügt (hier:
Fach?rztin für Psychiatrie und Psychotherapie), die die in der Abteilung zu bew?ltigenden Aufgaben (hier: Gerontopsychiatrie)
umfasst. (Leits?tze des Bearbeiters) 相似文献
172.
Oliver Schneider MD Christoph A. Stückle Elisabeth Bosch Corinna Gott Irenäus A. Adamietz 《Strahlentherapie und Onkologie》2004,180(8):502-509
BACKGROUND AND PURPOSE: The efficacy of radiation treatment (RT) for plantar heel pain has been reported repeatedly. Yet, the results referring to the pain relief rate, to long-term effects and prognostic factors are not consistent. In this paper, the effectiveness (pain relief rate and long-term results) and prognostic factors of RT for plantar heel pain have been investigated. PATIENTS AND METHODS: From January 2000 to October 2000, 62 patients (73 heels) with painful plantar heel spurs and a minimum pain history of 3 months were treated and evaluated in a prospective study. Mean age was 54 years (range 28-84 years). All patients were treated with a total dose of 5 Gy in seven fractions (= one series), given twice a week at a single-dose sequence of 0.25-0.25-0.5-1.0-1.0-1.0-1.0 Gy (10-MV photons, source-skin distance [SSD] 100 cm, direct portal, field size 12 x 17 cm). The mean duration of heel pain before RT was 26 weeks (= 6.5 months; range 3-120 months). By means of a visual analog scale (VAS) the patients had to self-assess the quantity of their heel pain once before, three times during and four times after RT at a longterm median follow-up of 28 and 40 months. Additionally, the patients had to assess their mechanical heel stress extent during RT. Effectiveness was estimated according to the patients' judgment of pain reduction. RESULTS: A significant reduction of heel pain extent measured by VAS has been observed already during the RT series (before RT: 6.3 +/- 1.5 vs. 3.8 +/- 2.1 at the end of RT; p < 0.001). 6 weeks after RT (FU 1) pain reduction (> 20%) was achieved in 60 heels (82.3%; n = 73), in 64 heels (91.4%; n = 70) after a mean follow-up of 28 months (FU 2), and in 61 heels (89.7%; n = 68) after a mean follow-up of 40 months (FU 3), respectively. Sufficient pain relief (> 80% compared to initial extent) was observed in 18/73 heels (24.6%) at FU 1 (FU 2: 42/70; 60.0%; FU 3: 37/68; 54.4%), including 13/73 heels (17.8%) with complete pain relief (FU 2: 39/70; 55.7%; FU 3: 36/68; 52.9%). Partial improvement (50-80% pain reduction) was observed in 27/73 heels (37.0%) at FU 1 (FU 2: 14/70; 20.0%; FU 3: 15/68; 22.1%), and minor partial improvement (20-50% pain reduction) in 15/73 heels (20.5%) at FU 1 (FU 2: 8/70; 11.4%; FU 3: 9/68; 13.2%), respectively. No change was seen in 13/73 heels (17.8%) at FU 1 (FU 2: 6/70; 8.6%; FU 3: 7/68; 10.3%). Older patients (p = 0.04) and patients who avoided heel stress during the period of RT (p < 0.01) demonstrated a better short-term response (FU 1); both effects were lost 28 and 40 months after RT. Moreover, significant differences in the extent of heel pain reduction by RT were observed in dependence on previous pain duration (at FU 2-3). CONCLUSION: The results confirm the high efficacy of RT in painful plantar spur and add new aspects to formerly published data concerning the time course of changes in heel pain reduction. Pain relief can be expected during and shortly after RT. In addition, the initial success can be transformed into effective long-term results > 2 years after RT; however, further improvement is not to be expected. As a new prognostic factor, the reduction of mechanical heel stress during RT may ameliorate the short-term results, whereas short heel pain history improves the long-term results. Especially for older patients, RT should be taken into consideration as primary treatment. 相似文献
173.
Stefan Wirth Ekkehard Euler Ulrich Linsenmaier Sandro-Michael Heining Dorothea Kotsianos Klaus-Jürgen Pfeifer Wolf Mutschler Maximilian Reiser 《Computer aided surgery》2004,9(1-2):27-38
OBJECTIVE: To analyse the image quality and diagnostic effectiveness of a new C-arm-based 3D imaging method (C-arm-CT) for intraoperative evaluation of screw osteosyntheses adjacent to a peripheral joint. MATERIALS AND METHODS: Insertion of screws into four cadaveric specimens simulated the surgical treatment of talus neck fractures. Ten orthopedic surgeons and 10 radiologists evaluated X-ray, C-arm fluoroscopy, C-arm-CT and CT images. RESULTS: The best image quality was obtained with X-rays (p < 0.001), followed by C-arm fluoroscopy (2D) and CT, with the C-arm-CT (3D) being rated lowest (p < 0.001). The most correct diagnoses were obtained with CT and C-arm-CT (with no statistical difference between them), while C-arm-fluoroscopy was inferior (p < 0.001) and X-rays were the worst (p < 0.05). CONCLUSIONS: Even if the image quality of C-arm-CT is definitely inferior to that of CT, screw misplacements can be reliably detected using C-arm-CT. As compared to the current standard procedures (intraoperative fluoroscopy and postoperative radiography), C-arm-CT performed better. C-arm-CT is ideally suited to the intraoperative diagnosis of high-contrast inquiries like bone fragments and OS material, especially at the extremities. Coupling of the new 3D imaging to existing navigation systems is possible. C-arm-CT will support the further development and implementation of open and minimally invasive surgical procedures. 相似文献
174.
Murat Kuloglu Murad Atmaca Bilal Ustündag Halit Canatan Omer Gecici Ertan Tezcan 《European neuropsychopharmacology》2003,13(2):67-71
The pathophysiology of akathisia still remains controversial. Iron deficiency was proposed to be an important factor in the development of akathisia. In the present study, it was aimed to compare levels of serum iron and linked variables in chronic akathisic (n=30), and non-akathisic patients (n=30) with schizophrenia and healthy controls (n=30) because of the controversy in the association of iron and akathisia. The Barnes Akathisia Scale for akathisia and Simpson-Angus Rating Scale for extrapyramidal side effects were used. Serum iron and linked variables and hematological profile of the patients and control subjects were determined. Serum iron levels were significantly lower both in akathisic and non-akathisic groups compared to the control group (P<0.001). Moreover, akathisic patients had significantly lower iron levels than non-akathisic patients (P<0.05). Total iron binding capacity was significantly higher in patients with akathisia compared to the control group (P<0.01). Although non-akathisic patients had a mild increase in total iron binding capacity, it was not statistically significant compared to the control group (P>0.05). Ferritin levels were determined to be significantly lower in both groups compared to the control group (P<0.01). In addition, there was a significant difference in ferritin levels between the patients with and without akathisia (P<0.05). In conclusion, our results support the hypothesis that an association between akathisia and iron metabolism exists. 相似文献
175.
Philippe Cattin Hitendu Dave Jürg Grünenfelder Gabor Szekely Marko Turina Gregor Zünd 《European journal of cardio-thoracic surgery》2004,25(5):786-790
OBJECTIVES: To characterize remaining coronary artery motion of beating pig hearts after stabilization with an 'Octopus' using an optical remote analysis technique. METHODS: Three pigs (40, 60 and 65 kg) underwent full sternotomy after receiving general anesthesia. An 8-bit high speed black and white video camera (50 frames/s) coupled with a laser sensor (60 microm resolution) were used to capture heart wall motion in all three dimensions. Dopamine infusion was used to deliberately modulate cardiac contractility. Synchronized ECG, blood pressure, airway pressure and video data of the region around the first branching point of the left anterior descending (LAD) coronary artery after Octopus stabilization were captured for stretches of 8 s each. Several sequences of the same region were captured over a period of several minutes. Computerized off-line analysis allowed us to perform minute characterization of the heart wall motion. RESULTS: The movement of the points of interest on the LAD ranged from 0.22 to 0.81 mm in the lateral plane (x/y-axis) and 0.5-2.6 mm out of the plane (z-axis). Fast excursions (>50 microm/s in the lateral plane) occurred corresponding to the QRS complex and the T wave; while slow excursion phases (<50 microm/s in the lateral plane) were observed during the P wave and the ST segment. The trajectories of the points of interest during consecutive cardiac cycles as well as during cardiac cycles minutes apart remained comparable (the differences were negligible), provided the hemodynamics remained stable. Inotrope-induced changes in cardiac contractility influenced not only the maximum excursion, but also the shape of the trajectory. Normal positive pressure ventilation displacing the heart in the thoracic cage was evident by the displacement of the reference point of the trajectory. CONCLUSIONS: The movement of the coronary artery after stabilization appears to be still significant. Minute characterization of the trajectory of motion could provide the substrate for achieving motion cancellation for existing robotic systems. Velocity plots could also help improve gated cardiac imaging. 相似文献
176.
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. 总被引:1,自引:0,他引:1
Jens P Bankstahl Claudia Kuntner Aiman Abrahim Rudolf Karch Johann Stanek Thomas Wanek Wolfgang Wadsak Kurt Kletter Markus Müller Wolfgang L?scher Oliver Langer 《Journal of nuclear medicine》2008,49(8):1328-1335
The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at the blood-brain barrier (BBB) and is believed to be implicated in resistance to central nervous system drugs. We used small-animal PET and (R)-11C-verapamil together with tariquidar, a new-generation P-gp modulator, to study the functional activity of P-gp at the BBB of rats. To enable a comparison with human PET data, we performed kinetic modeling to estimate the rate constants of radiotracer transport across the rat BBB. METHODS: A group of 7 Wistar Unilever rats underwent paired (R)-11C-verapamil PET scans at an interval of 3 h: 1 baseline scan and 1 scan after intravenous injection of tariquidar (15 mg/kg, n = 5) or vehicle (n = 2). RESULTS: After tariquidar administration, the distribution volume (DV) of (R)-11C-verapamil was 12-fold higher than baseline (3.68 +/- 0.81 vs. 0.30 +/- 0.08; P = 0.0007, paired t test), whereas the DVs were essentially the same when only vehicle was administered. The increase in DV could be attributed mainly to an increased influx rate constant (K1) of (R)-11C-verapamil into the brain, which was about 8-fold higher after tariquidar. A dose-response assessment with tariquidar provided an estimated half-maximum effect dose of 8.4 +/- 9.5 mg/kg. CONCLUSION: Our data demonstrate that (R)-11C-verapamil PET combined with tariquidar administration is a promising approach to measure P-gp function at the BBB. 相似文献
177.
Abstract – Traumatic dental injuries often occur to the teeth and their supporting tissues and they are the main reasons for emergency visit to a dental clinic. Management of a fracture depends on its position and the extent of root involvement. Horizontal root fractures are not seen frequently and the treatment consists of reduction and long‐term rigid fixation of the coronal segment. The present case demonstrates the successful management of two horizontally fractured maxillary central incisors with a follow‐up period of 9 months. 相似文献
178.
Ohne ZusammenfassungDie vorstehende Arbeit ist im Laboratorium des Herrn Prof. Cyon in der medicinischen Academie in St. Petersburg ausgeführt. 相似文献
179.
Dr. Küpper 《European archives of oto-rhino-laryngology》1880,15(4):271-272
Ohne Zusammenfassung 相似文献
180.
Bode-Köln König Felix Jaeger Hohmann Bode Junghanns Häbler Jüngling Westermann 《Archives of orthopaedic and trauma surgery》1941,41(2):320-328
Ohne Zusammenfassung 相似文献