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991.
Bayrak Harun Yıldız Yılmaz Olgaç Asburçe Kasapkara Çiğdem Seher Küçükcongar Aynur Zenciroğlu Ayşegül Yüksel Deniz Ceylaner Serdar Kılıç Mustafa 《Metabolic brain disease》2021,36(6):1213-1222
Metabolic Brain Disease - Nonketotic hyperglycinemia is an autosomal recessive inborn error of glycine metabolism, characterized by deficient activity of the glycine cleavage enzyme system. Classic... 相似文献
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The aim of pediatric transfusions should be based on the concept of avoiding unnecessary transfusions without jeopardizing the patient safety and providing correct blood components when there are well founded indications to transfuse. Despite considerable efforts from transfusion services to increase transfusion safety, transfusions are still associated with preventable and unpreventable adverse effects that may, in the worst case, have severe and fatal consequences. Transfusions to pediatric patients constitute a small proportion of all transfusions but have higher incidence of adverse events compared to adults. Pediatric transfusions consist of intrauterine transfusions, top-up transfusions to neonates and young children, exchange transfusions in the management of hemolytic disease of newborn (HDN), in addition to sickle cell crisis, chronic transfusion therapy in thalassemia patients, massive transfusion in trauma, HLA- and HPA-compatible platelets in immunized patients and neonates with fetal neonatal alloimmune thrombocytopenia (FNAIT). Packed red cells (PRCs) and platelet (PLT) concentrates are the most utilized blood components and will be reviewed here. 相似文献
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Hyun-Sop Choe Seung-Ju Lee Yong-Hyun Cho Mete Çek Zafer Tandoğdu Florian Wagenlehner Truls Erik Bjerklund-Johansen Kurt Naber 《Journal of infection and chemotherapy》2018,24(4):278-283
Objectives
To assess Asian data from Global Prevalence Study on Infections in Urology (GPIU study) which has been performed more than 10 years.Methods
Seventeen Asian countries participated in the GPIU study between 2004 and 2013. Data for these countries were collected from the web-based GPIU database. The point prevalence of urinary tract infections (UTI) and antimicrobial susceptibility of representative pathogens were analysed for Asian geographic regions.Results
A total of 6706 patients (5271 male, 1435 female) were assessed during the study period, and 659 patients were diagnosed with a UTI (9.8%). Of these UTI patients, 436 were male and 223 were female. Mean patient age was 54.9 ± 19.3 years. Pyelonephritis and cystitis were the most common clinical diagnoses, representing 30.7% and 29.9% of patients, respectively. Escherichia coli was the most frequently identified uropathogen (38.7%). For the patients with urinary tract infection, cephalosporins were the most frequently used antibiotics (34.4%), followed by fluoroquinolones (24.1%), aminoglycosides (16.8%). Fluoroquinolone resistance was relatively high (ciprofloxacin 54.9%, levofloxacin 39.0%), and cephalosporin resistance 42% (42.5–49.4%). Of the antibiotics evaluated, uropathogens had maintained the highest level of susceptibility to amikacin and imipenem (24.9% and 11.3% resistance rates, respectively).Conclusion
Uropathogens in many Asian countries had high resistance to broad-spectrum antibiotics. Knowledge of regional and local resistance data and prudent use of antibiotics are important for proper management of UTI in Asian countries. 相似文献994.
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Novel 4‐Thiazolidinones as Non‐Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA‐Dependent RNA Polymerase
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Çağdaş Kalkan Çiğdem Soydal Elgin Özkan Ata Maden Irfan Soykan 《Clinical autonomic research》2016,26(3):189-196