全文获取类型
收费全文 | 9333篇 |
免费 | 555篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 122篇 |
儿科学 | 164篇 |
妇产科学 | 221篇 |
基础医学 | 1380篇 |
口腔科学 | 111篇 |
临床医学 | 792篇 |
内科学 | 2030篇 |
皮肤病学 | 312篇 |
神经病学 | 687篇 |
特种医学 | 698篇 |
外科学 | 1417篇 |
综合类 | 59篇 |
一般理论 | 1篇 |
预防医学 | 417篇 |
眼科学 | 228篇 |
药学 | 480篇 |
中国医学 | 5篇 |
肿瘤学 | 800篇 |
出版年
2023年 | 44篇 |
2022年 | 63篇 |
2021年 | 148篇 |
2020年 | 123篇 |
2019年 | 166篇 |
2018年 | 215篇 |
2017年 | 168篇 |
2016年 | 176篇 |
2015年 | 223篇 |
2014年 | 241篇 |
2013年 | 384篇 |
2012年 | 554篇 |
2011年 | 592篇 |
2010年 | 337篇 |
2009年 | 330篇 |
2008年 | 562篇 |
2007年 | 535篇 |
2006年 | 530篇 |
2005年 | 493篇 |
2004年 | 497篇 |
2003年 | 485篇 |
2002年 | 379篇 |
2001年 | 171篇 |
2000年 | 180篇 |
1999年 | 190篇 |
1998年 | 115篇 |
1997年 | 97篇 |
1996年 | 87篇 |
1995年 | 75篇 |
1994年 | 74篇 |
1993年 | 55篇 |
1992年 | 115篇 |
1991年 | 99篇 |
1990年 | 116篇 |
1989年 | 106篇 |
1988年 | 101篇 |
1987年 | 100篇 |
1986年 | 86篇 |
1985年 | 71篇 |
1984年 | 77篇 |
1983年 | 72篇 |
1982年 | 51篇 |
1981年 | 45篇 |
1980年 | 41篇 |
1979年 | 47篇 |
1978年 | 43篇 |
1977年 | 41篇 |
1975年 | 39篇 |
1974年 | 45篇 |
1973年 | 45篇 |
排序方式: 共有9924条查询结果,搜索用时 61 毫秒
1.
2.
In recent years, there has been an increased focus on patient involvement in treatment planning in the health care system. To reduce the risk of the clinician moving towards paternalism, various methods have been introduced—shared decision making, among others. The goal of shared decision making is for the clinician and patient to share available evidence on the best treatment and to raise awareness on the needs and preferences of the patient as to make a genuinely informed choice. However, in the present article, we discuss to which degree paternalism can be avoided in light of the clinician's role as an authority with certain knowledge and expertise. Through the philosophical theory of reasons‐responsiveness, we discuss to which extend free will and control applies to the patient. Through theoretical analysis, we come to suggest that the clinician has a role as an ally rather than manipulator. 相似文献
3.
Low myocardial glucose uptake in Turner syndrome is unaffected by growth hormone: a randomized,placebo‐controlled FDG‐PET study 下载免费PDF全文
4.
T. Kapellen A. Galler K. Claus S. Heger D. Härtig Prof. Dr. W. Kiess 《Der Diabetologe》2006,2(2):167-181
Type 1 diabetes is one of the commonest chronic disorders encountered in children and adolescents. When it first becomes apparent in children, approximately 20% of them have clinical and biochemical signs of ketoacidosis (DKA). In the presence of unusual clinical symptoms it is necessary to consider the possibility of associated conditions, such as coeliac disease, immunothyroiditis and Addison’s disease. Children with diabetes must be treated by a multidisciplinary team made up of paediatrician, paediatric diabetes specialist, psychologist, social worker, ophthalmologist, dietitian, nurse and diabetes counsellor, making it essential for them to be treated in regional specialised centres. They are treated in their own psychosocial environment and their families are involved in the therapy. Comprehensive, multidisciplinary treatment strategies have now made it possible for these patients to enjoy normal physical wellbeing and near-normal psychosocial development. Prevention and early treatment of of disturbances associated with diabetes remain an important concern. The fact that type 2 diabetes must now be looked for in overweight children and adolescents is a new aspect of diabetes medicine. 相似文献
5.
The influence of short‐term confinement and moderate exercise on tibia development was investigated in growing pigs (36–41 kg, 10 weeks at the beginning of the study). Animals were kept for 2 weeks either in individual crates of 0.8 m2 (‘confinement’, n = 4) or kept in groups of four animals in large crates of 5.6 m2 without (‘control’) or with additional exercise (30 min walking at 5 days/week; ‘exercise’). Bone density and morphological parameters were evaluated by computer tomography (CT). Periosteal apposition and longitudinal growth were determined after polychrome sequential labelling in weekly intervals. Cortical areas of the cross sections at the mid‐shaft and at 75% of the length of the bone measured distal to the carpus by CT were significantly correlated to each other (r = 0.70) and revealed a significant reduction in confined animals. This difference was explained by lower periosteal apposition rates in these animals compared with exercised and group‐housed pigs. Similarly longitudinal growth and the formation and calcification of spongiosa of the tibiae were inhibited by confinement. Thus, 2 weeks of confinement led to significant differences in bone growth and metabolism in young growing piglets when compared with animals with moderate activity. 相似文献
6.
7.
D Falchetti F B de Carvalho P Clapuyt J de Ville de Goyet B de Hemptinne D Claus J B Otte 《Journal of pediatric surgery》1991,26(5):528-531
Biliary atresia is the most common indication for orthotopic liver transplantation (OLT) in children. The polysplenia syndrome anomalies, which occur in approximately 10% of children with biliary atresia, may represent special difficulties at liver transplantation. We have reviewed our experience with this syndrome in 116 children with biliary atresia who underwent liver transplantation between March 1984 and December 1989. The main features of the polysplenia syndrome, which included absence of the inferior vena cava, preduodenal portal vein, midgut malrotation, aberrant hepatic artery, and situs inversus, were encountered in 12 of the 116 children (10.3%). Severe portal vein hypoplasia (3.5 mm or smaller) was also present in 7 of these children. Eight patients received a complete and four received a reduced liver graft. The vascular anomalies increased the technical difficulty of OLT but could be surmounted, although they did contribute to the peroperative death of one child. The 1-month survival rate was 83% for the 12 children with features of the polysplenia syndrome and 88% for the other 92 children with biliary atresia alone. 相似文献
8.
K Thomsen B J Riis J S Johansen C Christiansen P R?dbro 《Gynecological endocrinology》1987,1(2):169-175
Bone turnover before and after withdrawal of estrogen/gestagen treatment was studied in a randomized trial with 110 healthy female volunteers, who had passed a natural menopause 6 months to 3 years before the start of the study. Urinary excretion of intravenously injected 99m-technetium diphosphonate was measured as an index of bone turnover; plasma bone Gla protein and serum alkaline phosphatase were measured as indices of bone formation; and fasting urinary excretion of hydroxyproline and calcium were measured as estimates of bone resorption. During 2 years of hormone treatment, all variables decreased highly significantly (p less than 0.001) to a constant low level. Three months after withdrawal all variables increased highly significantly (p less than 0.001) towards, but not above, pretreatment and placebo levels. We conclude that withdrawal of estrogen/gestagen replacement therapy in postmenopausal women increases bone turnover, but not in excess of pretreatment values. This indicates that bone loss (after withdrawal) is similar to that seen in the placebo group and that a rebound phenomenon is unlikely. 相似文献
9.
10.
Andreas Lange Claudia Kistler Tanja B. Jutzi Alexandr V. Bazhin Claus Detlev Klemke Dirk Schadendorf Stefan B. Eichmüller 《Experimental dermatology》2009,18(6):527-535
Abstract: The identification of tumor-specific proteins located at the plasma membrane is hampered by numerous methodological pitfalls many of which are associated with the post-translational modification of such proteins. Here, we present a new combination of detergent fractionation of cells and of subtractive suppression hybridization (SSH) to gain overexpressed genes coding for membrane-associated or secreted proteins. Fractionation of subcellular components by digitonin allowed sequestering mRNA of the rough Endoplasmatic reticulum and thereby increasing the percentage of sequences coding for membrane-bound proteins. Fractionated mRNAs from the cutaneous T-cell lymphoma (CTCL) cell line HuT78 and from normal peripheral blood monocytes were used for SSH leading to the enrichment of sequences overexpressed in the tumor cells. We identified some 21 overexpressed genes, among them are GPR137B, FAM62A, NOMO1, HSP90, SLIT1, IBP2, CLIF, IRAK and ARC. mRNA expression was tested for selected genes in CTCL cell lines, skin specimens and peripheral blood samples from CTCL patients and healthy donors. Several of the detected sequences are clearly related to cancer, but have not yet been associated with CTCL. qPCR confirmed an enrichment of these mRNAs in the rough endoplasmic reticulum fraction. RT-PCR confirmed the expression of these genes in skin specimens and peripheral blood of CTCL patients. Western blotting verified protein expression of HSP90 and IBP2 in HuT78. GPR137B could be detected by immunohistology in HuT78 and in keratinocytes of dysplastic epidermis, but also in sweat glands of healthy skin. In summary, we developed a new technique, which allows identifying overexpressed genes coding preferentially for membrane-associated proteins. 相似文献