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11.
S. Yu. Garmonov V. I. Pogorel’tsev N. S. Shitova T. A. Kiseleva E. V. Degterev M. I. Evgen’ev 《Pharmaceutical Chemistry Journal》2006,40(3):119-123
The pharmacokinetics of isonicotinic acid hydrazide upon joint administration with the immunomodulant ximedone has been investigated.
Ximedone influences the genetically determined parameters of the isonicotinic acid hydrazide pharmacokinetics. The dose-dependent
and temporal schedules of ximedone administration in humans are established, which favor the induction of acetylation processes
in patients.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 3–6, March, 2006. 相似文献
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V M Koshkin L M Rozofarov L A Za?tseva A V Karalkin G D Saitova 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》1990,(7):18-20
The authors have revealed a gradual development of venous hypertension and deceleration of the rate of venous blood flow in the damaged extremities in chronic obliterative arterial diseases. Decompensation of arterial hemodynamics is accompanied by the development of pronounced venous congestion with reduced venous pressure and tension. This may cause the incompetence of the deep venous valves. 相似文献
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L M Za?tsev 《Farmakologiia i toksikologiia》1988,51(3):106-110
The results of a comparative evaluation of methodical approaches to the analysis of the electrical and contractile activity of the uterus in laboratory animals during in vitro, in situ and in vivo investigation of potential uterotropic pharmacological agents are presented. For the analysis of the results there is proposed the method of mathematical processing of hysterograms including 20 parameters and the program of the calculation of the latter for the "Electronika MK-54" microcalculator. 相似文献
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Sokolova IN Savelov NA Chistiakova OV Sorokin KV Gurariĭ LL Shatinina NN 《Arkhiv patologii》2005,67(6):38-43
59 angiomyolipomas were studied: immunohistochemistry (IHC) was used in 24 cases, electron microscopy (EM) in 6 cases. 57 tumors had a typical structure, 2 did not contain fat component. Premelanosomes were found by EM in one tumor. Smooth muscle actin was found in all tumor cells. Involvement of lymph nodes was observed in 2 patients. Histogenesis of this tumor is discussed. 相似文献
19.
The aim of this work, that was carried out using Wistar rats, was to characterize the response of neurons of different morphofunctional types to amphetamine administration and to study the possibility of correction of these changes by delta-sleep inducing peptide (DSIP). Single intraperitoneal injection of 60 microg/kg of DSIP following a long term amphetamine administration (2.5 mg/kg for 3 weeks) was shown to result in normalization of brain metabolism, that was disturbed by the drug. The correcting DSIP effect was found in rat brain structures judging by the parameters of the state of proteins in neurons of sensomotor cortex and caudate nucleus and by the activity of enzymes of neurotransmitter metabolism, such as type A and B monoamine oxidases and acetylcholine esterase, that was determined in subfractions of the same brain structures. DSIP modulating effect in phenamine stereotypy supports its role as an adaptogen of intercenter relations in CNS pathology. 相似文献
20.
Morphology of microparticles of the microencapsulated measles vaccine was studied by cryofractography, transmission electronic microscopy and by atomic force microscopy; co-polymers of polyacrylic acid and of sodium-alginate (spermidine) complexes were used as the matrix. The different-composition microcapsules had clear-cut borders and a certain range of sizes; but they were different in morphology, and their structures and densities varied identically with regard for a medium acidity, which is apparently preconditioned by some conformation-type alterations of matrix molecules. The studied preparations can, probably, protect the viral material in the stomach aggressive medium and release the material to ensure its contact with the intestine lymph tissue; thereof, they can be referred to as promising for further study of mucosal vaccines. 相似文献