全文获取类型
收费全文 | 5262篇 |
免费 | 280篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 53篇 |
妇产科学 | 91篇 |
基础医学 | 716篇 |
口腔科学 | 171篇 |
临床医学 | 323篇 |
内科学 | 1407篇 |
皮肤病学 | 147篇 |
神经病学 | 307篇 |
特种医学 | 232篇 |
外科学 | 822篇 |
综合类 | 35篇 |
预防医学 | 156篇 |
眼科学 | 56篇 |
药学 | 388篇 |
中国医学 | 13篇 |
肿瘤学 | 627篇 |
出版年
2023年 | 24篇 |
2022年 | 44篇 |
2021年 | 93篇 |
2020年 | 66篇 |
2019年 | 77篇 |
2018年 | 97篇 |
2017年 | 80篇 |
2016年 | 110篇 |
2015年 | 96篇 |
2014年 | 128篇 |
2013年 | 165篇 |
2012年 | 259篇 |
2011年 | 280篇 |
2010年 | 154篇 |
2009年 | 141篇 |
2008年 | 231篇 |
2007年 | 243篇 |
2006年 | 236篇 |
2005年 | 249篇 |
2004年 | 248篇 |
2003年 | 250篇 |
2002年 | 257篇 |
2001年 | 169篇 |
2000年 | 200篇 |
1999年 | 152篇 |
1998年 | 55篇 |
1997年 | 64篇 |
1996年 | 65篇 |
1995年 | 44篇 |
1994年 | 46篇 |
1993年 | 47篇 |
1992年 | 121篇 |
1991年 | 108篇 |
1990年 | 105篇 |
1989年 | 110篇 |
1988年 | 89篇 |
1987年 | 78篇 |
1986年 | 76篇 |
1985年 | 75篇 |
1984年 | 71篇 |
1983年 | 43篇 |
1982年 | 27篇 |
1981年 | 24篇 |
1980年 | 16篇 |
1979年 | 26篇 |
1978年 | 32篇 |
1977年 | 30篇 |
1975年 | 18篇 |
1973年 | 15篇 |
1969年 | 17篇 |
排序方式: 共有5560条查询结果,搜索用时 31 毫秒
101.
Norito Takamura Toru Maruyama Etsuo Chosa Keiichi Kawai Yasuhiro Tsutsumi Yukie Uryu Keishi Yamasaki Tsuneo Deguchi Masaki Otagiri 《Drug metabolism and disposition》2005,33(4):596-602
To determine whether bucolome (5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine), a nonsteroidal anti-inflammatory agent, can reverse diuretic resistance of furosemide in patients with nephrotic syndrome, we examined the inhibitory effect of bucolome on the protein binding of furosemide in serum and urine. Bucolome significantly inhibited the protein binding of furosemide not only in serum but also in urine of preparation albumin (UPA), which mimics urinary albumin concentration in patients with nephrotic syndrome by ultrafiltration method. The binding percentage of furosemide to albumin was approximately 70% in UPA. With coadministration of bucolome to healthy volunteers, renal clearance of furosemide was increased, reflecting the increase of the free fraction of furosemide in serum. Furthermore, coadministration of bucolome caused a significant increase of urine volume and sodium concentration in urine. Even at higher urine levels of furosemide, the inhibitory effect of bucolome on the protein binding of furosemide in UPA remains constant, and changes in pH at weakly acidic pH levels (pH 5.5-6.5) did not alter the inhibitory effect of bucolome. Interestingly, coadministration of bucolome with furosemide in doxorubicin (Adriamycin)-induced nephrotic syndrome model rats alleviated the diuretic resistance. These results suggest that bucolome has a potent inhibitory effect on the protein binding of furosemide in the urine and can partially restore the diuretic response of furosemide in patients with nephrotic syndrome by increasing the free fraction of furosemide at the site of action. 相似文献
102.
Kamei H Yoshida S Yamasaki K Tajiri T Ozaki K Shirouzu K 《The Journal of surgical research》2000,89(1):20-25
BACKGROUND: The greater nitrogen loss that occurs with increasing severity of trauma is believed to occur because activation of the hypothalamus-pituitary axis is greater with severe injury. Cytokines in the brain stimulate the hypothalamus-pituitary-adrenal axis. This study was carried out to investigate whether the brain would recognize severity of trauma via TNF-alpha mRNA synthesis in the brain. METHODS: Male C57BL/6 mice (n = 70, BW: 20-28 g) were randomly assigned into four groups, (1) control (no anesthesia or incision), (2) anesthesia alone, (3) anesthesia plus laparotomy by short incision (short), and (4) anesthesia plus laparotomy by long incision (long). A laparotomy was carried out in the short and long groups by a 1.2-cm vertical incision and by a horizontal plus a vertical incision (2.4 x 2.4 cm), respectively. Exactly either 3 or 24 h after surgery, the animals were decapitated. TNF-alpha mRNA levels in the tissues were determined by semi-quantitative PCR. RESULTS: Nitrogen and catecholamine excretion were increased in the long wound group compared with the short wound group. Expression of TNF-alpha mRNA in the brain was greater in the long group after surgery than in the control, anesthesia, and short groups (brain, long: 0.150 +/- 0.005; P < 0.01 vs control, anesthesia alone, and short groups), but TNF-alpha levels in the plasma were the same in the short and long groups after surgery. CONCLUSION: Levels of TNF-alpha mRNA in the brain were enhanced according to the length of the wound probably because of greater neural stimuli from the wound site, and this elevation was involved in the greater nitrogen loss. 相似文献
103.
104.
Yamasaki N Matsumoto K Ohta Y Nishida T Adachi A Nakagawa K Kawakami K 《Kyobu geka. The Japanese journal of thoracic surgery》2000,53(9):791-794
We have experienced thoracoscopic surgery for benign solitary fibrous tumor of the parietal pleura. A 46-year-old woman was admitted to our hospital because of chest abnormal shadow. Under thoracoscopy the tumor that was connected to the parietal pleura with a wide pedicle was completely resected with combined parietal resection of the pleura. Pathological diagnosis was a benign solitary fibrous tumor developed from the connective tissues under the parietal pleura. Thoracoscopic surgery is well indicated for a solitary fibrous tumor and wide excision of the tumor with combined resection of the pleura is important to prevent a local recurrence. 相似文献
105.
106.
107.
108.
109.
Tsuyoshi Isosu Keisuke Yoshida Rieko Oishi Tsuyoshi Imaizumi Yuzo Iseki Norie Sanbe Yukihiro Ikegami Shinju Obara Shin Kurosawa Masahiro Murakawa 《Journal of clinical monitoring and computing》2018,32(4):693-697
To retrospectively investigate the effects of indigo carmine intravenous injection on oxygen reserve index (ORi?) in 20 patients who underwent elective gynecologic surgery under general anesthesia. The study subjects were patients who underwent elective gynecologic surgery under general anesthesia between April 2016 and January 2017, and were administered a 5-ml intravenous injection of 0.4% indigo carmine for clinical purposes during surgery with ORi monitoring. Changes in ORi within 20 min after indigo carmine injection were observed. A relevant decrease in ORi was defined as ≥?10% reduction in ORi from pre-injection level. ORi rapidly decreased after indigo carmine intravenous injection in all patients. In 10 of 19 patients, ORi decreased to 0 after indigo carmine injection. The median lowest value of ORi was 0 (range 0–0.16) and the median time to reach the lowest value of ORi was 2 min (range 1–4 min) after injection. ORi values returned to pre-injection levels within 20 min in 13 of 19 patients, and the median time to return to pre-injection levels was 10 min (range 6–16 min) after injection. During ORi monitoring it is necessary to consider the rapid reduction in ORi after intravenous injection of indigo carmine. 相似文献
110.