HPLC法测定齿囊耙齿菌固体发酵产物中麦角甾醇含量

目的建立齿囊耙齿菌固体发酵产物中麦角甾醇含量的测定方法。方法采用高效液相色谱方法,汉邦ODS-C18色谱分析柱(250×4.6mm,5μm),流动相为100%甲醇,流速1.0m L/min,检测波长282nm;柱温30℃。结果麦角甾醇进样量在0.20~1.40μg之间与吸收峰面积呈良好的线性关系,r=0.9999;平均加样回收率为100.07%,RSD(%)=1.91%。方法具有较高的专属性、准确性、重现性和可行性。结论该方法简便、准确、灵敏度好,为齿囊耙齿菌固体发酵产物质量评价提供了可靠依据。     

累积空腹血糖暴露对心脑血管事件的影响

目的 探讨累积空腹血糖暴露(cumFBG)对心脑血管事件的影响。方法 采用前瞻性队列研究方法,以连续参加2006-2007、2008-2009、2010-2011年3次健康体检的开滦集团职工为观察对象,排除心肌梗死、脑卒中、心力衰竭患者,最终纳入统计分析52 980例。以观察对象完成第3次健康体检时间为随访起点,以发生心脑血管事件为终点事件,随访终止时间为发生心脑血管事件、全因死亡或末次随访时间(2017年12月31日)。按cumFBG四分位分组,用Kaplan-Meier法计算各组心脑血管事件累积发病率,并用Log-rank检验比较各组心脑血管事件累积发病率的差异;采用Cox比例风险模型分析cumFBG对心脑血管事件的影响。结果 随访(6.76±1.03)年,cumFBG第1至第4四分位组心脑血管事件发病密度分别为3.42/千人年、4.57/千人年、5.68/千人年和9.53/千人年,且随着cumFBG增加,心脑血管事件、脑卒中、缺血性脑卒中累积发病率均呈上升趋势,经Log-rank检验及组间两两比较,差异有统计学意义(均P<0.01)。Cox比例风险模型显示校正年龄、性别、体...     

探讨低剂量索他洛尔与普罗帕酮治疗心律不齐的效果

目的 探讨低剂量索他洛尔与普罗帕酮治疗心律不齐的效果.方法 选取2017年4月至2019年8月于本院治疗的60例心律不齐患者为研究对象,随机分为对照组和观察组,各30例.对照组使用普罗帕酮进行治疗,观察组使用低剂量索他洛尔进行治疗.比较两组治疗效果,检测治疗前后QT离散度数据,记录治疗期间药物不良反应发生情况.结果 观...     

丁甘仁辨治哮喘思路探析

丁甘仁为孟河四大家的杰出代表,著名的中医临床家、教育家,其著录的《丁甘仁医案》一书,充分反映了丁甘仁诊疗临床各科之经验。《丁甘仁医案》卷四记录14例哮喘医案,可归纳丁甘仁对哮喘的辨治思路：治疗兼顾内外,疏外邪、化内饮以止咳喘,注重调理脏腑气机,重纳肾气、健脾气、降肺气以止咳喘;用药上多选温药化痰,以脾肺肾经药为主,善用鹅管石治喘急,海浮石化老痰,半夏配茯苓杜生痰之源,补骨脂配五味子治肾虚不纳,远志利肺气纳肾气;组方上采撷众方,汤丸并用。     

无创高频通气对新生儿呼吸衰竭血气、生命体征及并发症的影响

目的：研究无创高频通气对新生儿呼吸衰竭血气、生命体征及并发症的影响。方法：将医院新生儿重症监护室(NICU)2017年1月～2018年5月间收治的106例新生儿呼吸衰竭患儿采用随机数字表法均为分高频通气组(无创高频通气,n=53)与传统组[经鼻间歇正压通气(NIPPV),n=53],比较两组治疗效果。结果：治疗前、治疗3h及12h后,两组血气分析指标PaO₂、PaCO₂、SaO₂均发生显著性改变,PH水平均无显著性改变,其中高频通气组治疗12h后,PaO₂水平明显高于传统组同时间段水平,高频通气组治疗3h及12h后PaCO₂及显著低于传统组同时间段水平,SaO₂高于传统组同时间段水平;治疗前、治疗3h及12h后,两组生命体征MAP、HR及T水平均无显著性改变,两组治疗期间呼吸频率均呈下降趋势,且高频通气组治疗3h及12h后,呼吸频率均显著低于传统组同时间段水平;高频通气组治疗并发症发生率显著低于传统组;高频通气组治愈率显著高于传统组,两组放弃治疗及死亡率均...     

The Effect of Acidity Coefficient on the Crystallization Properties and Viscosity of Modified Blast Furnace Slag for Mineral Wool Production

The crystallization and viscosity of modified blast furnace slag are key factors in fiber forming conditions. In this paper, the crystallization behavior of modified blast furnace slag under continuous cooling conditions was studied by differential scanning calorimetry, and its crystallization kinetics with different acidity coefficients were established. On this basis, the evolution law of the crystallization phase and the influence of crystallization on the viscosity of modified blast furnace slag with different acidity coefficients were analyzed. The results indicated that the crystallization phases of slag with acidity coefficients of 1.05 and 1.20 were, respectively, Melilite and Anorthite. During the cooling process at the acidity coefficient of 1.05, the critical rates of precipitation of Melilite and Anorthite were 50 °C/s and 20 °C/s, respectively, while they were 20 °C/s and 15 °C/s, respectively, at the acidity coefficient of 1.20. With the increase of the acidity coefficient, the crystal growth mode of slag changed from two-dimensional and three-dimensional mixed crystallization to surface nucleation and one-dimensional crystallization. The crystallization activation energy of slag with acidity coefficients of 1.05 and 1.20 were 698.14 kJ/mol and 1292.50 kJ/mol, respectively. In addition, the change trend of viscosity was related to crystal size and content.     

抑郁障碍患者主观与客观认知功能的差异性研究

背景 抑郁障碍患者的主观认知功能与客观认知功能存在差异。目前,关于主客观认知功能差异影响因素的研究有限。目的 探索抑郁障碍患者主观和客观认知功能的差异及其影响因素,为进一步理解抑郁障碍患者认知功能受损情况提供参考。方法 纳入2022年1月13日—2023年12月11日在成都市第四人民医院门诊就诊或住院治疗的、符合《精神障碍诊断与统计手册（第5版）》（DSM-5）抑郁障碍诊断标准的77例患者为研究对象。采用蒙哥马利-艾森贝格抑郁量表（MADRS）评定患者抑郁症状严重程度,采用抑郁感知缺陷问卷（PDQ-D）和中国简版神经认知成套测验（C-BCT）分别评定患者的主观认知功能和客观认知功能,采用席汉残疾量表（SDS）评定患者的社会功能,以临床总体印象量表-疾病严重程度量表（CGI-SI）评定患者病情严重程度。采用Pearson相关分析考查年龄、受教育年限、MADRS总评分、SDS总评分、CGI-SI评分与主客观认知功能及其差异的相关性。采用多元线性回归探索主客观认知功能差异的影响因素。结果 是否用药的抑郁障碍患者PDQ-D总评分和主客观认知功能差异（D值）比较差异均有统计学意义（t=-4.2...     

Acute abdomen caused by torsion of the omentum: A pediatric case report

Rationale:Torsion of the omentum and infarction are rare and unusual disorders that often present as acute abdominal pain in the population. The diagnosis of omental torsion is based on clinical and imaging examinations.Patient concerns:A 7-year-old girl presented with acute right lower quadrant abdominal pain, with symptoms resembling acute appendicitis.Diagnosis:The patient was diagnosed with omental torsion based on imaging and laparoscopy.Interventions:Laparoscopic exploration was performed.Outcomes:The patient was discharged seven days after satisfactory postoperative recovery.Lessons:Omental torsion should be included in the differential diagnosis of acute abdominal pain, particularly in patients with free hemorrhagic fluid in the abdominal cavity and pelvis.     

The effect of 0.01% atropine on ocular axial elongation for myopia children: A protocol for systematic review and meta-analysis

Background:Orthokeratology (OK) has a significant effect on the control of myopia progression, and has been accepted by doctors and patients. A small number of studies have shown that the combination of OK and atropine can enhance myopia control. However, owing to individual differences, research groups, drug concentrations, and research design differences, the safety and effectiveness of the combined treatment still need to be verified. Therefore, the present meta-analysis aimed to determine the effect of 0.01% atropine on ocular axial elongation in myopic children.Methods:We searched the PubMed, Cochrane Library, and CBM databases from inception to March 1, 2022. Meta-analysis will be conducted using STATA version 14.0 and Review Manager version 5.3 softwares. We calculated the weighted mean differences (WMD) to analyze the change in ocular axial length (AL) between orthokeratology combined with 0.01% atropine (OKA) and OK alone. Cochran''s Q-statistic and I² test were used to evaluate the potential heterogeneity between studies. A sensitivity analysis was performed to evaluate the influence of single studies on the overall estimate. We will also perform subgroup and meta-regression analyses to investigate potential sources of heterogeneity. We will conduct Begger''s funnel plots and Egger''s linear regression tests to investigate the publication bias.Results:This systematic review aimed to determine the effect of 0.01% atropine on ocular axial elongation in children with myopia.Conclusions:These findings provide helpful evidence for the effect of 0.01% atropine on ocular axial elongation in myopic children.