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61.
G Rubin A D Firlik R R Pindzola E I Levy H Yonas 《Journal of stroke and cerebrovascular diseases》1999,8(1):9-16
The effect of reperfusion therapy on cerebral blood flow (CBF) in acute cerebral ischemia was studied using xenon-enhanced computed tomography (XeCT). The XeCT CBF studies of 10 patients were evaluated before and after thrombolytic therapy. CBF evidence of reperfusion was evaluated in relation to the angiographic results and the clinical outcomes. Six patients had occlusions of the middle cerebral artery and four of the internal carotid artery. The mean CBF of the ischemic areas before attempted reperfusion was 9 +/- 3 mL/100g/min compared with 34 +/- 9 mL/100g/min in the contralateral asymptomatic region (P<.001). Intra-arterial-thrombolysis was performed in nine patients, and in one patient the intravenous route was used. Reperfusion of the ischemic region was shown in 9 of 10 patients, both angiographically and with the XeCT CBF studies (the mean CBF increased from 9 +/- 3 mL/100g/min to 32 +/- 10 mL/100g/min, P<.001). Among the nine successfully reperfused patients, seven were neurologically improved, one was unchanged, and one died. The mean National Institutes of Health stroke scale in the eight reperfused survivors was 12 on admission and decreased to 6 on discharge. XeCT CBF measurements are correlated with the angiographic results and can assist in the understanding of the effects of thrombolytic therapy on CBF in acute stroke. Re-establishment of CBF is associated with an improved clinical outcome but exceptions can be found. Reperfusion can occur in ischemic brain regions even with very low CBF (approaching 0 mL/100g/min) although it is not associated with prevention of infarction. 相似文献
62.
Ronald C. Petersen Emily S. Lundt Terry M. Therneau Stephen D. Weigand David S. Knopman Michelle M. Mielke Rosebud O. Roberts Val J. Lowe Mary M. Machulda Walter K. Kremers Yonas E. Geda Clifford R. Jack 《Annals of neurology》2019,85(1):155-160
Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population‐based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75‐year‐old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85:155–160. 相似文献
63.
Krista L. Lanctôt Luis Agüera-Ortiz Henry Brodaty Paul T. Francis Yonas E. Geda Zahinoor Ismail Gad A. Marshall Moyra E. Mortby Chiadi U. Onyike Prasad R. Padala Antonios M. Politis Paul B. Rosenberg Emma Siegel David L. Sultzer Eleenor H. Abraham 《Alzheimer's & dementia》2017,13(1):84-100
Introduction
Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities.Methods
The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs.Results
Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches.Discussion
Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention. 相似文献64.
Glass N Fredland N Campbell J Yonas M Sharps P Kub J 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》2003,32(2):227-238
The goal of this synthesis is to provide a comprehensive assessment of the literature associated with dating violence in adolescence. Previous research findings on the prevalence, risk factors associated with victimization and perpetration, and potential health outcomes of dating violence are discussed. The importance of designing developmentally and culturally competent dating violence prevention and intervention strategies in the clinical setting is emphasized. This review is intended to assist health care professionals to develop interventions in their clinical settings to prevent and reduce adolescent dating violence. 相似文献
65.
Factors associated with diabetic retinopathy screening and regular eye checkup practice among diabetic patients attending Felege Hiwot Specialized Hospital
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66.
BackgroundAcute abdomen is a major surgical problem in Ethiopia with surgery for acute abdominal conditions accounting for roughly one-third of total emergency operations in many centers. This study was conducted with the aim of studying the pattern and outcome of surgically managed acute abdominal cases in a private general hospital in Addis Ababa, Ethiopia.MethodsThis was a retrospective cross-sectional study of acute abdominal cases in adult patients operated at Teklehaimanot General Hospital between January 1, 2018 and August 1, 2019.ResultsA total of 267 patients'' medical records were reviewed. The male to female ratio was 1.5:1 and majority of patients were between the age range of 20 to 40 years with mean age of 36±16 years. The average duration of symptoms before arrival was 71.1±84.4 hours (range 3 to 504 hours) and only 85 (31.8%) of patients reached to the Hospital within 24 hours or less of onset of symptoms. Acute appendicitis was the most common cause of acute abdomen; observed in 193 (72.3%) of the cases. Overall post-operative complication rate was 14.8% and post-operative mortality rate was 1.9%. It was found that delayed presentation (OR 2.01, 95% CI 1.64–7.84), old age (OR 1.51, 95% CI 1.89–3.59), and tachycardia at presentation (OR 2.85, 95% CI 1.03–6.82) were major predictors of morbidity and mortality in operated patients.ConclusionIn this study acute appendicitis accounted for the majority of cases operated for acute abdomen. Length of post-operative hospital stay, early post-operative complication rate, and overall mortality rate were found to be significantly lower in our series than other reports. 相似文献
67.
Maria Vassilaki MD PhD MPH Jeremy A. Syrjanen MS Walter K. Kremers PhD Philip T. Hagen MD David S. Knopman MD Michelle M. Mielke PhD Yonas E. Geda MD MSc Rabe E. Alhurani MD MSc Mary M. Machulda PhD Rosebud O. Roberts MB ChB MS Ronald C. Petersen MD PhD 《Journal of the American Geriatrics Society》2020,68(6):1250-1255
68.
Cerebral blood flow measured by xenon-enhanced computed tomography may provide useful information in victims of severe head injury. To assess the effect of stable xenon inhalation on intracranial pressure, intracranial pressure was measured in 17 mechanically ventilated patients with severe head injury undergoing cerebral blood flow studies with xenon-enhanced computed tomography. Under hypocapnic conditions, mean intracranial pressure increased by less than 1 mm Hg (p less than 0.05) late in the inhalation period only in patients whose baseline intracranial pressure was less than 20 mm Hg. It was concluded that under hypocapnic conditions, the magnitude of this increase in intracranial pressure does not prohibit the safe evaluation of cerebral blood flow in victims of head injury using xenon-enhanced computed tomography. 相似文献
69.
70.
D Gur H Yonas D L Jackson S K Wolfson H Rockette W F Good E E Cook V C Arena J A Willy G S Maitz 《Investigative radiology》1985,20(7):672-677
Simultaneous measurements of cerebral blood flow have been performed in baboons to assess the correlation between the acute and invasive nondiffusible microsphere technique and the noninvasive xenon-enhanced CT method. Blood flows in small tissue volumes (approximately 1 cm3) were directly compared. The results of these studies demonstrate a statistically significant association between the two methods (P less than .001). Similar correlations were obtained by both the Kendall tau (tau) and the Spearman (r) methods. The problems and limitations of such correlations are discussed. 相似文献