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41.
42.
Complications of Preoperative Balloon Test Occlusion of the Internal Carotid Arteries: Experience in 300 Cases
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Robert W. Tarr Charles A. Jungreis Joseph A. Horton Susan Pentheny Laligam N. Sekhar Chandra Sen Ivo P. Janecka Howard Yonas 《Skull base》1991,1(4):240-244
Treatment of some tumors and aneurysms of the skull base may require internal carotid artery (ICA) sacrifice. Preoperatively to determine the dependence of the cerebral blood flow on a particular vessel, we perform a balloon test occlusion (BTO) by temporarily occluding the vessel in an awake patient. During occlusion, clinical evaluations and cerebral blood flow measurements are assessed. We have performed 300 BTOs. Eleven patients (3.7%) have had complications. Six (2%) were asymptomatic dissections. Five (1.7%) had neurologic deficits that persisted beyond the test period. Of these five, one was back to baseline in less than 24 hours, one recovered completely in a week, and one (0.33%) had a minimal but persistent dysphasia. These latter three cases are unexplained but might have resulted from unrecognized dissections or embolic events. Finally, one patient with a persistent deficit required energency surgery for reasons unrelated to the BTO and was therefore difficult to assess, and one required emergency middle cerebral artery embolectomy and repair of the dissection. The preoperative knowledge of carotid dependence in cases in which the ICA is at risk is essential, since vascular grafts or alternative surgical approaches are necessary in patients unable to tolerate carotid sacrifice. Since approximately 15 to 20% of the population falls into this category, a preoperative BTO appears justified. 相似文献
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44.
Value of transcranial Doppler examination in the diagnosis of cerebral vasospasm after subarachnoid hemorrhage 总被引:3,自引:0,他引:3
In 21 patients with subarachnoid hemorrhage secondary to ruptured intracranial aneurysms, we performed serial neurological evaluations, transcranial Doppler examinations, and cerebral blood flow (CBF) determinations. We classified 8 patients as having vasospasm (delayed neurological deterioration, appropriate reduction of CBF) and 13 patients as having no spasm on the basis of this information. Transcranial Doppler flow velocities in the middle cerebral artery and the anterior cerebral artery were significantly elevated for the group with vasospasm on posthemorrhage Days 4 through 12. Elevation of transcranial Doppler velocities preceded clinical signs of cerebral ischemia. The maximal transcranial Doppler flow velocities achieved were compared on the basis of the extent of clot on early computed tomographic (CT) scans. The mean anterior cerebral artery flow velocities were significantly different between CT Grades II and III. The initial transcranial Doppler flow velocities were compared on the basis of the patient's Hunt and Hess grade upon admission. The flow velocities for Grade V patients were significantly lower than those for Grade IV patients. Transcranial Doppler flow velocities were compared with arteriographically observed anterior cerebral artery and middle cerebral artery radii in 12 instances. The correlation was poor, but the data should be interpreted cautiously in view of the small number of arteriograms. We conclude that transcranial Doppler examination has considerable potential in the early diagnosis of delayed ischemic neurological deficit (clinical vasospasm) in patients with subarachnoid hemorrhage. 相似文献
45.
M E Linskey C A Jungreis H Yonas W L Hirsch Jr L N Sekhar J A Horton J E Janosky 《AJNR. American journal of neuroradiology》1994,15(5):829
PURPOSETo evaluate stable xenon-enhanced CT cerebral blood flow with balloon test occlusion as a predictor of stroke risk in internal carotid artery sacrifice.METHODSAbrupt internal carotid artery occlusion was performed by surgical or endovascular means below the origin of the ophthalmic artery in 31 normotensive patients who were assessed preoperatively by a 15-minute clinical balloon test occlusion followed by an internal carotid artery-occluded xenon CT cerebral blood flow study.RESULTSOne patient, who passed the clinical test occlusion but exhibited regions of cerebral blood flow less than 30 mL/100 g per minute on the occlusion xenon CT cerebral blood flow study went on to have a fatal stroke corresponding exactly to the region of reduced blood flow. Thirty patients passed both components of the preoperative stroke-risk assessment. Neuroimaging demonstrated possible flow-related infarctions, which subsequently developed in three patients. Two patients were asymptomatic, and one patient was left with a mild residual hemiparesis.CONCLUSIONSOur protocol provided a statistically significant reduction in subsequent infarction rate and infarction-related death rate when compared with a control group of normotensive abrupt internal carotid artery occlusion patients who did not undergo any preoperative stroke-risk assessment (reported in the literature). The estimated false-negative rate for our preoperative assessment protocol ranged from 3.3% to 10% depending on the assessment of the cause of the three potentially flow-related infarctions. Although life-threatening major vascular territory infarctions have been avoided, our protocol is less sensitive to changes predicting smaller, often minimally symptomatic, vascular border zone infarctions and does not predict postoperative thromboembolic strokes. 相似文献
46.
D Gur H Yonas S K Wolfson P Wozney J G Colsher W F Good B C Good D L Herbert E E Cook 《Journal of computer assisted tomography》1984,8(6):1124-1127
A noninvasive technique for measuring blood flow by xenon-enhanced X-ray transmission CT has been developed and reported quite extensively in recent years. In this method nonradioactive xenon gas is inhaled, and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential CT. Time-dependent xenon concentration within various tissue segments is used to derive local blood flow maps. The method has been amply discussed in relation to assessment of local cerebral blood flow. Its application to other body organs is explored in this paper, in which results from six preliminary blood flow studies in the liver and kidneys of nonhuman primates are reported. Blood flow in renal cortex ranged from 150 to 280 ml/100 cc/min and hepatic tissue perfusion from 80 to 120 ml/100 cc/min. The advantages and limitations of the method in such applications are discussed. 相似文献
47.
Stable xenon-enhanced CT measurement of cerebral blood flow in reversible focal ischemia in baboons 总被引:1,自引:0,他引:1
When the lateral striate arteries of the baboon are temporarily occluded for either 20 or 60 minutes, a near-cessation of blood flow is followed by a dramatic, transient local increase in blood flow values. These findings are evident from serial xenon (Xe)-computerized tomography (CT) measurement of cerebral blood flow (CBF). In this study, 20 minutes of vessel occlusion resulted in brief (less than 1 hour) hyperemia, with no subsequent CT alteration and minimal random neuronal injury. Sixty minutes of occlusion resulted in a more prolonged hyperemia, a low-density area on CT images within 3 hours of reperfusion, and infarction of all cellular elements within the anterior lentiform nucleus. The Xe-CT method provides a sensitive, noninvasive technique for examining sequential alterations of CBF in small regions deep within the brain. This method of recording CBF also permits correlative studies of cerebral infarction, both clinically and experimentally, and allows reasonable inference about the probabilities of neuronal tissue damage with or without reperfusion. 相似文献
48.
Blood flow mapping in the human liver by the xenon/CT method 总被引:1,自引:0,他引:1
D Gur W F Good D L Herbert H Yonas P Wozney D H Van Thiel S K Wolfson 《Journal of computer assisted tomography》1985,9(3):447-450
In the noninvasive, nonradioactive xenon/CT method of blood flow measurement, xenon gas is inhaled, and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential CT; time-dependent xenon concentration within various tissue segments is then used to derive local blood flow maps. The usefulness of the method in the assessment of local cerebral blood flow has been documented. In this paper we explore its application to blood flow measurement in the human liver. In our preliminary clinical studies, hepatic blood flow ranged from 50 to 120 ml/100 cc/min in normal and adequately supplied tissue, and lower flow values were observed in tissue with abnormal function. The advantages and limitations of the method in such applications are discussed. 相似文献
49.
J M Mathis J D Barr C A Jungreis H Yonas L N Sekhar D Vincent S L Pentheny J A Horton 《AJNR. American journal of neuroradiology》1995,16(4):749
PURPOSETo describe experience with 500 temporary balloon occlusions of the internal carotid artery, with particular emphasis on the techniques and complications.METHODSTemporary occlusion of the internal carotid artery was accomplished endovascularly using various balloon-catheter combinations. These temporary balloon occlusions were combined, when possible, with cerebral blood flow analysis with stable xenon-enhanced CT.RESULTSComplications related to this procedure occurred in 16 (3.2%) patients. Eight (1.6%) patients had asymptomatic complications. There were 8 who experienced neurologic changes. Six (1.2%) of these were transient; two (0.4%) were permanent. There were no deaths.CONCLUSIONSTemporary balloon occlusion of the internal carotid artery, believed helpful in identifying patients at risk of stroke during abrupt carotid artery sacrifice, can be performed with an acceptably low complication rate. 相似文献
50.
Stippler M Crago E Levy EI Kerr ME Yonas H Horowitz MB Kassam A 《Journal of neurosurgery》2006,105(5):723-729
OBJECT: Despite the application of current standard therapies, vasospasm continues to result in death or major disability in patients treated for ruptured aneurysms. The authors investigated the effectiveness of continous MgSO4 infusion for vasospasm prophylaxis. METHODS: Seventy-six adults (mean age 54.6 years; 71% women; 92% Caucasian) were included in this comparative matched-cohort study of patients with aneurysmal subarachnoid hemorrhage on the basis of computed tomography (CT) findings. Thirty-eight patients who received continuous MgSO4 infusion were matched for age, race, sex, treatment option, Fisher grade, and Hunt and Hess grade to 38 historical control individuals who did not receive MgSO4infusion. Twelve grams of MgSO4 in 500 ml normal saline was given intravenously daily for 12 days if the patient presented within 48 hours of aneurysm rupture. Vasospasm was diagnosed on the basis of digital substraction angiography, CT angiography, and transcranial Doppler ultrasonography, and evidence of neurological deterioration. Symptomatic vasospasm was present at a significantly lower frequency in patients who received MgSO4 infusion (18%) compared with patients who did not receive MgSO4 (42%) (p = 0.025). There was no significant difference in mortality rate at discharge (p = 0.328). A trend toward improved outcome as measured by the modifed Rankin Scale (p = 0.084), but not the Glasgow Outcome Scale (p = 1.0), was seen in the MgSO4 treated group. CONCLUSIONS: Analysis of the results suggests that MgSO4 infusion may have a role in cerebral vasospasm prophylaxis if therapy is initiated within 48 hours of aneurysm rupture. 相似文献