全文获取类型
收费全文 | 635篇 |
免费 | 37篇 |
国内免费 | 5篇 |
专业分类
儿科学 | 36篇 |
妇产科学 | 20篇 |
基础医学 | 85篇 |
口腔科学 | 2篇 |
临床医学 | 73篇 |
内科学 | 164篇 |
皮肤病学 | 53篇 |
神经病学 | 39篇 |
特种医学 | 25篇 |
外科学 | 43篇 |
综合类 | 13篇 |
预防医学 | 64篇 |
眼科学 | 7篇 |
药学 | 40篇 |
肿瘤学 | 13篇 |
出版年
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 9篇 |
2016年 | 8篇 |
2015年 | 9篇 |
2014年 | 13篇 |
2013年 | 24篇 |
2012年 | 16篇 |
2011年 | 14篇 |
2010年 | 17篇 |
2009年 | 10篇 |
2008年 | 24篇 |
2007年 | 22篇 |
2006年 | 29篇 |
2005年 | 23篇 |
2004年 | 25篇 |
2003年 | 18篇 |
2002年 | 32篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 19篇 |
1998年 | 16篇 |
1997年 | 4篇 |
1996年 | 13篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 18篇 |
1992年 | 10篇 |
1991年 | 8篇 |
1990年 | 16篇 |
1989年 | 20篇 |
1988年 | 19篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 18篇 |
1984年 | 9篇 |
1983年 | 19篇 |
1982年 | 12篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1961年 | 2篇 |
1956年 | 3篇 |
1838年 | 2篇 |
排序方式: 共有677条查询结果,搜索用时 15 毫秒
91.
92.
93.
Hypospadias is a common congenital anomaly with a prevalence estimated to be as high as 1 in 125 live male births. Its etiology is not entirely resolved but is embryologic in origin and has been attributed to fusion defects. Several authors believe it is a manifestation of intersex. Experience to date has produced a general consensus with regard to indications, timing and surgical principles for repair of the hypospadiac meatus. While two-stage procedures have been the mainstay of therapy, successful single-stage procedures have recently been developed. The prevention and management of the complications of persistant chordee, fistula and stricture make hypospadias repair one of the more challenging urologic procedures. 相似文献
94.
95.
P Barlas TD Hernndez KL McFadden 《Focus on Alternative and Complementary Therapies》2010,15(3):225-226
McFadden KL, Hernández TD. Cardiovascular benefits of acupressure (Jin Shin) following stroke. Complement Ther Med 2010; 18: 42–8. 相似文献
96.
L Moreno SK McMaster T Gatheral LK Bailey LS Harrington N Cartwright PCJ Armstrong TD Warner M Paul-Clark JA Mitchell 《British journal of pharmacology》2010,160(8):1997-2007
Background and purpose:
Gram-negative bacteria contain ligands for Toll-like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors. Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1. Activation of NOD1 by the specific agonist FK565 results in a profound vascular dysfunction and experimental shock in vivo.Experimental approach:
Here, we have analysed a number of pharmacological inhibitors to characterize the role of key signalling pathways in the induction of NOS2 following TLR4 or NOD1 activation.Key results:
Vascular smooth muscle (VSM) cells expressed NOD1 mRNA and protein, and, after challenge with Escherichia coli or FK565, NOS2 protein and activity were induced. Macrophages had negligible levels of NOD1 and were unaffected by FK565, but responded to E. coli and LPS by releasing increased NO and expression of NOS2 protein. Classic pharmacological inhibitors for NF-κB (SC-514) and mitogen-activated protein kinase (SB203580, PD98059) signalling pathways inhibited responses in both cell types regardless of agonist. While TLR4-mediated responses in macrophages were specifically inhibited by the pan-caspase inhibitor z-VAD-fmk and the PKC inhibitor Gö6976, NOD1-mediated responses in VSM cells were inhibited by the Rip2 inhibitor PP2.Conclusions and implications:
Our findings suggest a selective role for NOD1 in VSM cells, and highlight NOD1 as a potential novel therapeutic target for the treatment of vascular inflammation. 相似文献97.
98.
Rhodes SD Fernández FM Leichliter JS Vissman AT Duck S O'Brien MC Miller C Wilkin AM Harris GA Hostetler DM Bloom FR 《Journal of immigrant and minority health / Center for Minority Public Health》2011,13(6):1183-1186
This study documented the types and quality of sexual health medications obtained by immigrant Latinos from non-medical sources. Samples of the medications were purchased from non-medical sources in the rural Southeast by trained native Spanish-speaking "buyers". Medications were screened the presence of active pharmaceutical ingredients using mass spectrometry. Eleven medications were purchased from tiendas and community members. Six were suggested to treat sexually transmitted diseases, one was to treat sexual dysfunction, one was to prevent pregnancy, and two were to assist in male-to-female transgender transition or maintenance. All medications contained the stated active ingredients. Findings suggest that medications are available from non-medical sources and may not be used as indicated. Interventions that target immigrant Latinos within their communities and rely on existing structures may be effective in reducing barriers to medical and healthcare services and increasing the proper use of medications to reduce potential harm. 相似文献
99.
Combining key ideas from the knowledge-gap hypothesis and communication infrastructure theory, the present study aimed to explain the relations among individuals' education, access to community-based communication resources, and knowledge of chronic diseases (diabetes, hypertension, breast cancer, and prostate cancer) among African Americans and Latinos in Los Angeles. Rather than explore the effect of isolated communication resources, this study explored the effect of an integrated connection to community-based storytellers on chronic disease knowledge. The authors hypothesized that individuals' access to a community-based communication infrastructure for obtaining and sharing information functions as an intervening step in the process where social inequality factors such as education lead to chronic disease knowledge gaps in a local community context. With random samples of African Americans and Latinos in Los Angeles, the authors found that access to community-based communication resources plays a mediating role in the case of breast cancer and diabetes knowledge, but not in hypertension and prostate cancer knowledge. The authors discussed these findings on the basis of communication infrastructure theory and knowledge-gap hypothesis. 相似文献
100.