4-Methylpyrazole and the cutaneous vascular sensitivity to alcohol in Orientals

Twelve healthy subjects of Oriental ancestry were challenged with topical applications of lower aliphatic alcohols and aldehydes after topical pretreatment consisting of 4-methylpyrazole in hydrophilic ointment on the volar aspect of one forearm and hydrophilic ointment alone on the contralateral volar forearm. Cutaneous blood flow was monitored by laser Doppler velocimetry. Pretreatment with 4-methylpyrazole, a specific inhibitor of alcohol dehydrogenase, led to a significant decrease in the cutaneous vascular response to the alcohols as a group, but did not lead to changes in the cutaneous vascular response to the aldehydes as a group. Among the individual alcohols, pretreatment with 4-methylpyrazole reduced the response significantly to all concentrations of 1-propanol and 1-butanol. The means of the vascular response to the different concentrations of ethanol decreased, but not significantly. Additionally, 4-methylpyrazole did not have an independent effect on cutaneous blood flow. These results are consistent with the view that the cutaneous vascular reaction to primary alcohols applied topically to the skin of Orientals is provoked, in large part, by the corresponding aldehyde.     

Nodular colloid degeneration: distinctive histochemical and ultrastructural features

We recently evaluated a patient with a unique form of nodular colloid degeneration. Lesions consisted of pruritic, purpuric plaques involving the upper and lower extremities and the neck. Examination of a biopsy specimen revealed large, fissured masses of amorphous material in addition to solar elastosis. The amorphous material showed negative reactions to stains for amyloid, and other histochemical studies showed results similar to those for colloid milium. The amorphous masses demonstrated a marked positive reaction to the Verhoeff-van Gieson stain for elastin. Electron microscopic examination revealed masses of degenerated elastic tissue bordered by fibrillar material that resembled amyloid morphologically. We believe this case represents a nodular form of solar degeneration with clinical and histologic resemblances to both colloid milium and cutaneous amyloidosis.     

Effect of subdepressor clonidine on flushing reactions in rosacea. Change in malar thermal circulation index during provoked flushing reactions

The effects of clonidine hydrochloride, an agent effective in suppressing other types of flushing reactions, were investigated in patients with erythematotelangiectatic rosacea. Clonidine hydrochloride, 0.05 mg, was given orally twice daily for two weeks. Mean arterial BP was not altered during clonidine treatment. Flushing reactions provoked with water at 60 degrees C, red wine, and chocolate were not suppressed during clonidine treatment. Clonidine did lead to malar hypothermia. It may be that any treatment benefit obtained from the reduction in vascular reactivity by clonidine in rosacea is offset by the malar hypothermia.     

诺氟沙星缓释片的初步研究

本文初步研究了诺氟沙星缓释片的处方组成。并对不同处方进行了体外溶出试验,实验结果表明：本品的体外释药可维持12h以上且体外溶出符合一级动力学过程。     

薄层扫描法测定藤茶中二氢杨梅素的含量

目的：建立藤茶质量控制的方法,方法：采用薄层扫描法测定藤茶中二氢杨梅素的含量。结果：藤茶中二氢杨梅素的含量３８．１７％－３８．５４％,回收率为９８．５％,ＲＳＤ为１．６％,结论：该法快速、简单、稳定、测定结果准确、可靠。