全文获取类型
收费全文 | 1972781篇 |
免费 | 150503篇 |
国内免费 | 3567篇 |
专业分类
耳鼻咽喉 | 29036篇 |
儿科学 | 62539篇 |
妇产科学 | 58177篇 |
基础医学 | 287139篇 |
口腔科学 | 56596篇 |
临床医学 | 170297篇 |
内科学 | 381071篇 |
皮肤病学 | 40471篇 |
神经病学 | 156330篇 |
特种医学 | 77702篇 |
外国民族医学 | 524篇 |
外科学 | 306877篇 |
综合类 | 47178篇 |
现状与发展 | 3篇 |
一般理论 | 542篇 |
预防医学 | 148756篇 |
眼科学 | 46252篇 |
药学 | 149915篇 |
1篇 | |
中国医学 | 3772篇 |
肿瘤学 | 103673篇 |
出版年
2018年 | 17951篇 |
2015年 | 18036篇 |
2014年 | 25252篇 |
2013年 | 38597篇 |
2012年 | 52626篇 |
2011年 | 55999篇 |
2010年 | 32888篇 |
2009年 | 31010篇 |
2008年 | 53839篇 |
2007年 | 58519篇 |
2006年 | 58755篇 |
2005年 | 57965篇 |
2004年 | 56095篇 |
2003年 | 54285篇 |
2002年 | 52963篇 |
2001年 | 85094篇 |
2000年 | 87294篇 |
1999年 | 74259篇 |
1998年 | 21765篇 |
1997年 | 19716篇 |
1996年 | 19775篇 |
1995年 | 18691篇 |
1994年 | 17805篇 |
1993年 | 16520篇 |
1992年 | 61402篇 |
1991年 | 60463篇 |
1990年 | 59505篇 |
1989年 | 57763篇 |
1988年 | 53903篇 |
1987年 | 53017篇 |
1986年 | 50621篇 |
1985年 | 48582篇 |
1984年 | 36907篇 |
1983年 | 31944篇 |
1982年 | 19524篇 |
1981年 | 17592篇 |
1980年 | 16371篇 |
1979年 | 35996篇 |
1978年 | 25616篇 |
1977年 | 21838篇 |
1976年 | 20479篇 |
1975年 | 22326篇 |
1974年 | 26941篇 |
1973年 | 26035篇 |
1972年 | 24722篇 |
1971年 | 22923篇 |
1970年 | 21616篇 |
1969年 | 20880篇 |
1968年 | 19353篇 |
1967年 | 17357篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Metoclopramide, a substituted benzamide derivative, was orally administered to a patient with intractable hiccups. Dysphoria, akathisia, depressed mood with suicidal ideation, insomnia, racing thoughts, and labile affect were seen following the administration of metoclopramide. The episode met criteria for an organic affective syndrome. It is suggested that the mental status of patients undergoing metoclopramide therapy be monitored, since these symptoms have not been previously reported. 相似文献
992.
Horner's syndrome or oculosympathetic paralysis is not an uncommon finding in patients with head and neck neoplasms. While in most cases the syndrome is easily established at the bedside, it can be confirmed and topographically defined as a central, preganglionic, or postganglionic lesion through sequential pharmacologic testing. The importance of such localization lies in differentiating neoplasia vs. a benign condition as the cause of the syndrome. Such variants as congenital Horner's, an alternating Horner's, and a pseudo-Horner's syndrome are discussed in regard to their differential features. 相似文献
993.
994.
995.
Comparison of local and general anesthesia in tension-free (Lichtenstein) hernioplasty: a prospective randomized trial 总被引:3,自引:0,他引:3
To compare pulmonary effects, postoperative pain and fatigue, morbidity, patient satisfaction, and cost of different anesthetic
techniques for inguinal hernia repair, 50 patients were randomized to local and general anesthesia groups (LA and GA). All
patients received the same premedications and the same postoperative analgesic regimen. The standardized postoperative analgesic,
intramuscular pyroxicam 20 mg, was given to all patients in the recovery room and an additional 20 mg on the same day was
given as requested by each patient. Pulmonary function studies and arterial blood gas analysis were performed 1 h prior to
the operation and at the postoperative 8th and 24th hours. All patients underwent Lichtenstein's tension-free hernioplasty.
Postoperative pain and fatigue were registered 8 h and 24 h after the operation. A questionnaire was filled out by the patients,
and they were asked to give grades for the general comfort of the anesthesia and the surgical procedure (1=worst, 10=best).
Postoperative pulmonary function tests were significantly poorer in the GA group both on 8th- and 24th-hour measurements (P<0.05). Patients who underwent LA had significantly lower PCO2 and higher PO2 at the postoperative 8th hour (P<0.05). Mean postoperative pain and fatigue scores revealed a significant difference in favor of local anesthesia at only
the 8th hour (P<0.05). There were two complications, one in each group (a hematoma in LA and a urinary retention in GA). Patient satisfaction
grades were not different in the two groups. We conclude that LA in inguinal hernia repair does not adversely affect pulmonary
functions, patients feel less pain, and patient satisfaction is comparable to that with GA.
Electronic Publication 相似文献
996.
Donor interleukin-4 promoter gene polymorphism influences allograft rejection after heart transplantation. 总被引:3,自引:0,他引:3
Femke J Bijlsma Joyce vanKuik Marcel G J Tilanus Nicolaas deJonge Erik H Rozemuller Jan G van den Tweel Frits H J Gmelig-Meyling Roel A deWeger 《The Journal of heart and lung transplantation》2002,21(3):340-346
BACKGROUND: The cytokine interleukin-4 (IL-4) is secreted mainly by activated T lymphocytes and characterizes the T-helper 2 (Th2) sub-type. In transplantation Th2 cells are believed to induce graft tolerance. Previous studies revealed that patients with a relatively high frequency of IL-4 producing helper T lymphocytes (HTL) before heart transplantation (HTX) had no or less rejection episodes compared with patients with a low frequency of IL-4 producing HTL. Three single nucleotide polymorphisms (SNPs) have been identified in the promoter region of the IL-4 gene, which influence promoter strength. We investigated whether there was a correlation between SNP genotypes in the IL-4 promoter and heart failure, and rejection after HTX. METHODS: Seventy HTX patients, 61 donors, and 36 controls were genotyped for the 3 SNPs by sequencing. RESULTS: Of the SNPs at -285 and -81, only the C and A alleles, respectively, were found in this study. Both alleles were found for the -590 SNP. No relation between patient genotype of the SNP at -590 and heart failure and rejection was found. However, incidence of rejection was significantly lower in patients that received a donor heart with the T-positive genotype compared with patients that received a heart from a T-negative donor. Patients who had the T-negative genotype and received a heart from a T-positive donor, suffered significantly less from rejection than T-negative patients that received a T-negative donor heart. This was not significant in the T-positive patient group. CONCLUSIONS: This indicates that IL-4 production within the donor heart and by cells from the donor is important for reducing incidence of episodes of rejection. 相似文献
997.
998.
G Harry Van Lenthe Marieke M. M. Willems Nico Verdonschot Maarten C De Waal Malefijt Rik Huiskes 《Acta orthopaedica》2002,73(6):630-637
Although the revision rates for modern knee prostheses have decreased drastically, the total number of revisions a year is increasing because many more primary knee replacements are being done. At the time of revision, bone loss is common, which compromises prosthetic stability. To improve stability, intramedullary stems are often used. The aim of this study was to estimate the effects of a stem, its diameter and the interface bonding conditions on patterns of the bone remodeling in the distal femur.
We created finite element models of the distal half of a femur in which 4 types of knee prostheses were placed. The bone remodeling process was simulated using a strain-adaptive bone remodeling theory. The amount of such remodeling was determined by calculating the changes in bone mineral density in 9 regions of interest from simulated DEXA scans.
The computer simulation model showed that revision prostheses tend to cause more bone resorption than primary ones, especially in the most distal regions. Predicted long-term bone loss due to a revision prosthesis with a thin stem equalled that around a prosthesis with an intercondylar box. However, strong regional differences were found- the stemmed prostheses having more bone loss in the most distal areas and some bone gain in the more proximal ones. A prosthesis with a thick stem led to an increase in bone loss. When the prosthesis-cement interface was bonded, more bone loss was predicted than with an unbonded interface. These results suggest that a stem which increases stability initially may reduce stability in the long term. This is due to an increase in stress shielding and bone resorption. 相似文献
We created finite element models of the distal half of a femur in which 4 types of knee prostheses were placed. The bone remodeling process was simulated using a strain-adaptive bone remodeling theory. The amount of such remodeling was determined by calculating the changes in bone mineral density in 9 regions of interest from simulated DEXA scans.
The computer simulation model showed that revision prostheses tend to cause more bone resorption than primary ones, especially in the most distal regions. Predicted long-term bone loss due to a revision prosthesis with a thin stem equalled that around a prosthesis with an intercondylar box. However, strong regional differences were found- the stemmed prostheses having more bone loss in the most distal areas and some bone gain in the more proximal ones. A prosthesis with a thick stem led to an increase in bone loss. When the prosthesis-cement interface was bonded, more bone loss was predicted than with an unbonded interface. These results suggest that a stem which increases stability initially may reduce stability in the long term. This is due to an increase in stress shielding and bone resorption. 相似文献
999.
1000.
C. Sch?fer H. H. Klünemann B. Ibach J. Mueller A. Putzhammer I. Trender-Gerhard G. Schuierer H. E. Klein 《Der Nervenarzt》2002,24(1):879-882
Wir berichten über den ersten Fall von polyzystischer lipomembran?ser Osteodysplasie oder “brain, bone and fat disease” in
Deutschland. Die nach dem Erstbeschreibern auch als Morbus J?rvi-Hakola-Nasu bezeichnete Erkrankung ist bisher vor allem in
Japan und in Finnland beschrieben worden. Einzelne F?lle wurden aus Schweden, Norwegen, Italien, Südafrika, Belgien und den
USA berichtet. Im deutschsprachigen Raum ist bisher ein Fall aus ? ver?ffentlicht worden. 相似文献