全文获取类型
收费全文 | 588篇 |
免费 | 71篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 23篇 |
妇产科学 | 12篇 |
基础医学 | 109篇 |
口腔科学 | 13篇 |
临床医学 | 77篇 |
内科学 | 142篇 |
皮肤病学 | 5篇 |
神经病学 | 26篇 |
特种医学 | 38篇 |
外科学 | 58篇 |
综合类 | 32篇 |
预防医学 | 53篇 |
眼科学 | 5篇 |
药学 | 34篇 |
中国医学 | 4篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 3篇 |
2022年 | 9篇 |
2021年 | 43篇 |
2020年 | 11篇 |
2019年 | 13篇 |
2018年 | 16篇 |
2017年 | 10篇 |
2016年 | 16篇 |
2015年 | 20篇 |
2014年 | 29篇 |
2013年 | 28篇 |
2012年 | 31篇 |
2011年 | 33篇 |
2010年 | 22篇 |
2009年 | 19篇 |
2008年 | 34篇 |
2007年 | 26篇 |
2006年 | 23篇 |
2005年 | 25篇 |
2004年 | 22篇 |
2003年 | 20篇 |
2002年 | 15篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 12篇 |
1998年 | 18篇 |
1997年 | 16篇 |
1996年 | 17篇 |
1995年 | 9篇 |
1994年 | 12篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 12篇 |
1987年 | 6篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有665条查询结果,搜索用时 46 毫秒
101.
Skin and soft tissue infections (SSTIs) span a broad spectrum of clinical entities from limited cellulitis to rapidly progressive
necrotizing fasciitis, which may be associated with septic shock or a toxic shock-like syndrome. These infections may manifest
initially as pyodermas that then progress; alternatively, they may arise from metastatic spread of microorganisms from a distant
focus. Regardless of the source, SSTIs may lead to critical illness. The complex interplay of environment, host, and pathogen
are important to consider when evaluating SSTIs and planning appropriate therapy. The keys to a successful outcome are early
identification of risk factors for specific pathogens and early initiation of empiric antimicrobial therapy. For certain types
of SSTIs, surgical intervention for diagnosis and/or therapy is also required. 相似文献
102.
103.
104.
105.
Tho DQ Török ME Yen NT Bang ND Lan NT Kiet VS van Vinh Chau N Dung NH Day J Farrar J Wolbers M Caws M 《Antimicrobial agents and chemotherapy》2012,56(6):3074-3079
HIV-associated tuberculous meningitis (TBM) has high mortality. Aside from the devastating impact of multidrug resistance (MDR) on survival, little is understood about the influence of other bacterial factors on outcome. This study examined the influence of Mycobacterium tuberculosis drug resistance, bacterial lineage, and host vaccination status on outcome in patients with HIV-associated TBM. Mycobacterium tuberculosis isolates from the cerebrospinal fluid of 186 patients enrolled in two studies of HIV-associated TBM in Ho Chi Minh City, Vietnam, were tested for resistance to first-line antituberculosis drugs. Lineage genotyping was available for 122 patients. The influence of antituberculosis drug resistance and M. tuberculosis lineage on 9-month mortality was analyzed using Kaplan-Meier survival analysis and Cox multiple regression models. Isoniazid (INH) resistance without rifampin resistance was associated with increased mortality (adjusted hazard ratio [HR], 1.78, 95% confidence interval [CI], 1.18 to 2.66; P = 0.005), and multidrug resistance was uniformly fatal (n = 8/8; adjusted HR, 5.21, 95% CI, 2.38 to 11.42; P < 0.0001). The hazard ratio for INH-resistant cases was greatest during the continuation phase of treatment (after 3 months; HR, 5.05 [95% CI, 2.23 to 11.44]; P = 0.0001). Among drug-susceptible cases, patients infected with the "modern" Beijing lineage strains had lower mortality than patients infected with the "ancient" Indo-Oceanic lineage (HR, 0.29 [95% CI, 0.14 to 0.61]; P = 0.001). Isoniazid resistance, multidrug resistance, and M. tuberculosis lineage are important determinants of mortality in patients with HIV-associated TBM. Interventions which target these factors may help reduce the unacceptably high mortality in patients with TBM. 相似文献
106.
NT Tham VT Hang TH Khanh do C Viet TT Hien J Farrar Nv Chau HR van Doorn 《Diagnostic microbiology and infectious disease》2012,74(2):131-136
Real-time polymerase chain reaction (PCR) can be considered the gold standard for detection of influenza viruses due to its high sensitivity and specificity. Roche has developed the RealTime ready Influenza A/H1N1 Detection Set, consisting of a generic influenza virus A PCR targeting the M2 gene (M2 PCR) and a specific PCR targeting the hemagglutinin (HA) of A/H1N1-pdm09 (HA PCR, 2009 H1N1), with the intention to make a reliable, rapid, and simple test to detect and quantify 2009 H1N1 in clinical samples. We evaluated this kit against the US Centers for Disease Control and Prevention (USCDC)/World Health Organization real-time PCR for influenza virus using 419 nose and throat swabs from 210 patients collected in 3 large hospitals in Ho Chi Minh City, Vietnam. In the per-patient analysis, when compared to CDC PCR, the sensitivity and specificity of the M2 PCR were 85.8% and 97.6%, respectively; the sensitivity and specificity of HA PCR were 88.2% and 100%, respectively. In the per-sample analysis, the sensitivity and specificity in nose swabs were higher than those in throat swabs for both M2 and HA PCRs. The viral loads as determined with the M2 and HA PCRs correlated well with the Ct values of the CDC PCR. Compared with the CDC PCR, the kit has a reasonable sensitivity and very good specificity for the detection and quantification of influenza A virus and A/H1N1-pdm09. However, given the current status of 2009 H1N1, a kit that can detect all circulating seasonal influenza viruses would be preferable. 相似文献
107.
Maj Gen PP Varma )Col TS Ramakrishnan ) Lt Col Pragnya Singh ) 《Medical Journal Armed Forces India》2011,67(1):9-14
Introduction: Chronic kidney disease (CKD) is associated with significant morbidity and mortality. Screening and detection of early stages of CKD can help institute interventions that may delay the progression of the disease. One aim was to study the prevalence of early stages of CKD in the Army.Methods: A cross-sectional study ofArmy Personnel in an Army cantt in Central India was carried out. All participants filled a structured questionnaire and anthropometric data was collected. Investigative profile included routine urine exam, semi-quantitative microalbuminuria (MAU), serum creatinine, lipid profile and fasting blood glucose. Glomerular Filteration rate (eGFR) was calculated using the Modification of Diet in Renal Diseases (MDRD) study equation.Result: A total of 1920 subjects were examined with 731 (38.07%) from Arms and 1189 (6I.93%) from Services. 348 were excluded and of the remaining 1572 subjects, 141 (8.97%) had MAU and 157 (9.99%) had deranged Albumin Creatinine Ratio (ACR). Mean eGFR by MDRD equation was 102 ± 25.84 ml/min/1.73m2. Early CKD was seen in 150 (9.54%) with 84 (5.34%) in stage I CKD, 55 (3.5%) in stage II and 11 (0.7%) in stage III. Multiple logistic regression showed BMI > 23, the presence of DM and HTN were independent risk factors for CKD.Conclusion: 9.54 % of healthy army personnel were found to have early stages of CKD. Institution of screening programs can result in early detection of CKD. 相似文献
108.
109.
Ho Thanh Tam Thi Le Minh Tam Truong Quang Vinh Nguyen Vu Quoc Huy Cao Ngoc Thanh 《Sexuality and disability》2020,38(1):123-133
Sexuality and Disability - This study aimed to assess the rate and level of depression, anxiety, and stress among people with infertility and the association between psychological disorders and... 相似文献
110.
Christina Gavino Sibylle Mellinghoff Oliver A. Cornely Marija Landekic Catherine Le Melanie Langelier Makan Golizeh Susanna Proske Donald C. Vinh 《Mycoses》2018,61(1):61-65
CARD9 deficiency (CANDF2; OMIM# 212050) is an autosomal‐recessive monogenic inborn error of immunity conferring susceptibility to invasive fungal diseases, including the very distinct syndrome of spontaneous central nervous system candidiasis, in which opportunistic yeast of the genus Candida infect the central nervous system (either brain parenchyma and/or meninges) in the absence of trauma, chemotherapy or underlying systemic disease. We present a patient with spontaneous endophthalmitis of the right eye due to Candida albicans; further investigations revealed concomitant cerebral abscess. She had a history of left endophthalmitis due to the dematiaceous mould, Aureobasidium pullulans, 15 years earlier. Targeted sequencing of the CARD9 gene revealed 2 novel variants (c.184G>A and c.288C>T). Analysis in silico predicted each variant altered splicing, which was confirmed by sequencing of cDNA from proband and carrier offsprings: c.184G>A results in a 4‐base pair frameshift deletion with loss of allelic expression; c.288C>T results in an in‐frame 36‐bp pair deletion with detectable protein. CARD9 deficiency can present with a phenotype of spontaneous candidal endophthalmitis. We report 2 novel mutations in CARD9, both affecting splicing, expanding the range of morbid variants causing CARD9 deficiency, emphasising the importance of both genomic and cDNA sequencing for this condition. 相似文献