Results of the national survey of borderline ovarian tumors in Spain

MATERIAL AND METHODS: Retrospective multi-center analysis of women diagnosed with borderline ovarian tumor and treated between January 1990 and December 1997. A national survey was conducted, in which 457 patients from 27 centers corresponding to ten of Spain's autonomous communities were analyzed. RESULTS: Four hundred fifty-seven women with borderline ovarian tumor were analyzed. The mean age of patients was 45.5+/-16.9 years. Of these, 390 patients (85.3%) were at stage I, 8 (1.8%) were at stage II and 36 (7.9%) at stage III. A bilateral tumor was observed in 63 women (13.8%). The mean tumor size was 14.2 cm and in 88 cases (19.3%) the tumor was on the surface of the ovary. Microinvasion was observed in 25 (5.5%) cases, and 29 women (6.3%) showed a micropapillary pattern. Study of the factors related to the appearance of peritoneal implants revealed positive tumor markers (OR 15.02: 1.9-32.9) and a tumor on the ovarian surface (OR 8.0: 1.8-127) to be independent risk factors. With respect to recurrence, the presence of peritoneal implants at the time of initial surgery (OR 3.4: 1.1-10.4) and signs of microinvasion in the anatomicopathological study (OR 5.5: 1.5-17.8) were found to be independent risk factors. The overall survival rate in our series was 97% with a mean follow-up of 88.3 months. The survival rate by stage was 97% for stage I, 100% for stage II and 97% for stage III. CONCLUSIONS: Although borderline ovarian tumors have an excellent prognosis, they are not exempt from a risk of recurrence. Characterization of patients with borderline ovarian tumor is essential in order to prevent their evolution. Likewise, the taking on board of risk factors will enable more selective treatments to be offered in each case.     

以第二课堂为载体培养学生科研创新能力探讨

营养与食品卫生教研室在学校深化教育改革倡导下,为提高预防医学专业学生综合素质和培养创新思维,将科研课题精心设计并移植到第二课堂教学中,依托学院开展的“预防论坛”形式积极参与打擂。该次有益的尝试为医学生提前介入科学研究,提高对科研的认知,培养高素质科研专才起到了积极作用。     

夫精宫腔内人工授精周期数与妊娠率的相关性分析

目的分析夫精宫腔内人工授精(IUI)治疗周期数与临床结局的相互关系。方法回顾性分析2196个IUI周期的病例资料,比较治疗周期次数与临床妊娠率的关系。结果 1625例患者行2196个IUI周期,有329例获临床妊娠,周期妊娠率为15%,夫妇累积妊娠率为20.2%。第1、第2、第3、第4周期组的临床妊娠率分别为15.2%、14.9%、12.9%、0.0%,各组间比较差异无统计学意义(P>0.05);1、2、3、4个周期组的周期临床妊娠率分别为19.7%、10.1%、8.9%、6.3%,累积妊娠率分别为19.7%、20.2%、26.7%、25.0%。两两比较分析显示1个周期组与2个周期组及3个周期组的周期临床妊娠率差异均有统计学意义(P<0.01),但其他组间比较差异无统计学意义(P>0.05);各组间累积妊娠率比较差异无统计学意义(P>0.05)。结论 IUI治疗中适当增加助孕周期数可以增加累积临床妊娠率。     

Effects on physiologic measures of appetite from intragastric balloon and endoscopic sleeve gastroplasty: results of a prospective study

Background:Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored care.Methods:We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) (n = 18) placed between October 2016 and June 2017 or underwent endoscopic sleeve gastroplasty (ESG) (n = 23) from March 2018 to June 2018. Patients underwent physiologic appraisal at 3 months with ¹³C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (%TBWL) at 3 and 6 months using best-fit linear regression.Results:The change in T50 at 3 months correlated with %TBWL at 3 months for IGB (P = 0.01) and ESG (P = 0.01) but with greater impact on %TBWL in IGB compared to ESG (R² = 0.42 vs. 0.26). Change in T50 at 3 months was predictive of weight loss at 6 months for IGB (P = 0.01) but not ESG (P = 0.11). ESG was associated with greater decrease in MTV compared to IGB (340.25 ± 297.97 mL vs. 183.00 ± 217.13 mL, P = 0.08), indicting an enhanced effect on satiation through decreased gastric accommodation. Changes in MTV at 3 months did not correlate with %TBWL for either IGB (P = 0.26) or ESG (P = 0.49) but trended toward significance for predicting %TBWL at 6 months for ESG (P = 0.06) but not IGB (P = 0.19).Conclusion:IGB and ESG both induce weight loss but likely through distinct gastric motor function phenotypes, and gastric emptying may predict future weight loss in patients with IGB.     

《中药鉴定学》创新性实验方法探讨研究——贵州省道地药材天麻、杜仲、吴茱萸的真伪鉴定与质量评价

目的：探索生药学创新性的实验方法及培养学生的创新思维、动手能力和团队协作精神的作用。方法：在教师的指导下,成立3个学生课题小组,分别选取贵州道地药材药材天麻、杜仲、吴茱萸,通过文献查阅与综述、药材市场调查与样品收集、药材鉴定、质量评价、实验记录与报告书写等完成相应的研究工作。结果：学生掌握了如何进行文献查阅与综述,如何开展药材市场调查,怎样收集到合格的药材,如何制定实验方案,物资准备包括哪些内容,选用什么样的性状、显微、理化鉴定方法对药材进行鉴定,如何评价中药的质量,如何正确书写实验记录与报告。结论：通过具体的实验项目使学生了解进行中药品种鉴定与质量评价的基本思路、方法与程序;通过与本学科课堂理论学习结合,增加学生学习兴趣,提高学生参与科学实验的积极性,培养学生的创新思维;通过实验过程的全程参与,特别是样品收集、物资准备和实验操作的锻炼,学生的动手能力普遍提高;通过课题小组的分工与协作,锻炼学生独立从事及完成一项任务的能力,改善学生之间、学生与社会之间沟通及协作能力。     

开展营养与食品卫生学第二课堂 提高军队学员卫勤保障综合技能

在军事预防医学本科生第九学期的营养与食品卫生学习阶段,开展"部队食堂食品卫生监督"为主题的第二课堂实践活动,旨在提高军队学员综合卫勤保障能力及综合素质。     

不同类型糖代谢紊乱与老年危重病人APACHEⅡ评分相关性分析

目的:探讨不同类型的糖代谢紊乱与老年危重病人APACHEⅡ评分的相关性。方法:将147例内科危重病人分成3组(原有糖尿病组、应激性高血糖组和正常血糖组),分析比较三组病人在APACHEⅡ评分和病死率的区别。结果:糖尿病组、应激性高血糖组的APACHEⅡ评分和死亡率高于血糖正常组,以应激性高血糖组最为明显。结论:各种糖代谢紊乱均可加重老年危重病人的病情发展,尤其要重视应激性高血糖的处理。     

四川省北川县擂鼓镇家庭结构试点调查:2008年汶川大地震前后对比

目的:客观对比擂鼓镇2008年汶川大地震前后家庭结构情况并分析探讨其原因。方法:于2012年对四川省北川县擂鼓城乡进行深入到户试点调查,将调查结果与采用同样调查方法的2007年数据(调查点包括擂鼓农村)进行纵向对比分析,另就2012年数据横向对比擂鼓城乡间以及羌汉两族家庭结构情况。结果与结论:此次调查的擂鼓城乡与2007年擂鼓农村户均人口均约为4左右。汶川大地震后(2012年)擂鼓农村家庭的户均人数与地震前(2007年)相比减少了7%;擂鼓农村2007年家庭96%为核心、主干与夫妇家庭,地震后(2012年)这个比例下降至80%,扩大和其它家庭显著增加,类型更趋多元化。擂鼓城镇与农村不分民族来看家庭结构差异无统计学意义(P>0.05)。擂鼓农村羌族与汉族对比:家庭规模羌汉差距不大(P>0.05);家庭类型差异有统计学意义(P<0.05),汉族家庭更趋多元化;家庭代际差异有统计学意义(P<0.05),汉族家庭更趋大户型。     

女性输尿管完全重复畸形的诊治(附38例报告)

目的探讨女性输尿管完全重复畸形的诊断及治疗。方法回顾性分析2000年1月至2005年12月所收治并获得随访的38例女性输尿管完全重复畸形患者。影像学检查确定诊断,所有患者均进行手术治疗。结果术后取得满意疗效,无进行性肾积水、肾功能损害,尿失禁完全消失。结论影像学检查在女性输尿管完全重复畸形的诊断中意义重大,手术治疗可取得满意疗效。     

重组E.coli. LLO/OVA明显增强小鼠CD11c细胞活性及抗肿瘤免疫

目的 探讨重组E.coli. LLO/OVA 诱导C57BL/6小鼠机体免疫的途径,观察其免疫后小鼠机体抑制B16-OVA黑色素瘤的效果.方法 磁珠分离E.coli. LLO/OVA及E.coli. OVA免疫后小鼠脾脏CD11c、CD4 和CD8 T细胞并检测CD11c细胞诱导同源CD4 和CD8 T增殖水平和细胞因子分泌程度;流式细胞检测小鼠脾脏内肿瘤抗原OVA257-264 SIINFEKL特异的细胞毒T细胞含量.比较两种E.coli. 免疫后,恶性黑色素瘤B16-OVA在小鼠肺内形成瘤结节的数量.结果 与E.coli. OVA相比, E.coli. LLO/OVA免疫后小鼠脾脏CD11c细胞诱导同源CD4 T细胞增殖作用增强、IL-2分泌增高;同时诱导CD8 T细胞增殖和IFN-γ分泌的作用也明显增强;OVA257-264 SIINFEKL特异的CD8 T细胞含量也明显增高;小鼠肺内形成B16-OVA瘤结节平均数明显减少. 结论 E.coli. LLO/OVA有效地诱导小鼠CD11c细胞活化,增强其对CD4 T细胞增殖和IL-2分泌以及对CD8 T细胞增殖、IFN-γ分泌的作用,诱导了更多的OVA特异的CD8 T细胞,使机体产生了更强的抗肿瘤免疫.