全文获取类型
收费全文 | 6871篇 |
免费 | 484篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 168篇 |
妇产科学 | 130篇 |
基础医学 | 1211篇 |
口腔科学 | 128篇 |
临床医学 | 679篇 |
内科学 | 1445篇 |
皮肤病学 | 152篇 |
神经病学 | 653篇 |
特种医学 | 297篇 |
外国民族医学 | 17篇 |
外科学 | 693篇 |
综合类 | 34篇 |
一般理论 | 8篇 |
预防医学 | 569篇 |
眼科学 | 105篇 |
药学 | 480篇 |
中国医学 | 13篇 |
肿瘤学 | 530篇 |
出版年
2024年 | 8篇 |
2023年 | 58篇 |
2022年 | 31篇 |
2021年 | 111篇 |
2020年 | 88篇 |
2019年 | 125篇 |
2018年 | 261篇 |
2017年 | 180篇 |
2016年 | 180篇 |
2015年 | 226篇 |
2014年 | 222篇 |
2013年 | 293篇 |
2012年 | 583篇 |
2011年 | 617篇 |
2010年 | 279篇 |
2009年 | 244篇 |
2008年 | 478篇 |
2007年 | 627篇 |
2006年 | 534篇 |
2005年 | 545篇 |
2004年 | 453篇 |
2003年 | 432篇 |
2002年 | 370篇 |
2001年 | 42篇 |
2000年 | 44篇 |
1999年 | 48篇 |
1998年 | 23篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 26篇 |
1990年 | 13篇 |
1989年 | 11篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1974年 | 6篇 |
1973年 | 11篇 |
1972年 | 9篇 |
1970年 | 5篇 |
1969年 | 6篇 |
1968年 | 5篇 |
1967年 | 11篇 |
1966年 | 5篇 |
排序方式: 共有7371条查询结果,搜索用时 15 毫秒
71.
Valéria Martins Araújo CARNEIRO Ana Cristina Barreto BEZERRA Maria do Carmo Machado GUIMAR?ES Maria Imaculada MUNIZ-JUNQUEIRA 《Journal of applied oral science : revista FOB》2012,20(5):503-509
Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism
against bacterial challenges in periodontitis. Phagocytosis by neutrophils has
already been evaluated, whereas phagocytic function of monocytes has hardly been
addressed so far.
Objectives
The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis.Material and Methods
The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis.Results
A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using non-sensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test).Conclusion
The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis. 相似文献72.
Assumpção TC Eaton DP Pham VM Francischetti IM Aoki V Hans-Filho G Rivitti EA Valenzuela JG Diaz LA Ribeiro JM 《The American journal of tropical medicine and hygiene》2012,86(6):1005-1014
Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature. 相似文献
73.
74.
75.
Pérez Moreiras MI Alvarez Gutierrez AE Couselo Villanueva JM Iglesias Porto E González López R Arija Val F 《Gastroenterologia y hepatologia》2012,35(7):476-479
Meckel's diverticulum (MD) is a persistent embryonic remnant occurring in 2% of the general population. This entity is usually clinically silent and is only discovered when complications occur. Diagnosis is rarely made preoperatively. Surgical resection of symptomatic MD is widely accepted but the most appropriate management of asymptomatic MD remains unclear. We present a case of MD that summarizes some of the complications that may occur. The peculiarity of this case was that the complications were caused by a leiomyoma. The presence of tumoral disease in MD accounts for 3.2% of complications. The most common neoplasm is carcinoid tumor. Few publications have reported benign neoplasms in MD, probably due to their low incidence. 相似文献
76.
Dabiré H Barthélémy I Blanchard-Gutton N Sambin L Sampedrano CC Gouni V Unterfinger Y Aguilar P Thibaud JL Ghaleh B Bizé A Pouchelon JL Blot S Berdeaux A Hittinger L Chetboul V Su JB 《Basic research in cardiology》2012,107(1):1-9
Little is known about the vascular function and expression of endothelial and neuronal nitric oxide synthases (eNOS and nNOS) in Duchenne muscular dystrophy (DMD). Bradykinin is involved in the regulation of eNOS expression induced by angiotensin-converting enzyme inhibitors. We characterized the vascular function and eNOS and nNOS expression in a canine model of DMD and evaluated the effects of chronic bradykinin treatment. Vascular function was examined in conscious golden retriever muscular dystrophy (GRMD) dogs with left ventricular dysfunction (measured by echocardiography) and in isolated coronary arteries. eNOS and nNOS proteins in carotid arteries were measured by western blot and cyclic guanosine monophosphate (cGMP) content was analyzed by radioimmunoassay. Compared with controls, GRMD dogs had an impaired vasodilator response to acetylcholine. In isolated coronary artery, acetylcholine-elicited relaxation was nearly absent in placebo-treated GRMD dogs. This was explained by reduced nNOS and eNOS proteins and cGMP content in arterial tissues. Chronic bradykinin infusion (1 μg/min, 4 weeks) restored in vivo and in vitro vascular response to acetylcholine to the level of control dogs. This effect was NO-mediated through upregulation of eNOS and nNOS expression. In conclusion, this study is the first to demonstrate that DMD is associated with NO-mediated vascular endothelial dysfunction linked to an altered expression of eNOS and nNOS, which can be overcome by bradykinin. 相似文献
77.
78.
Valérie Chaput Frédérique Amsellem Isabel Urdapilleta Pauline Chaste Marion Leboyer Richard Delorme Véronique Goussé 《Research in autism spectrum disorders》2013,7(9):1062-1067
Previous findings from researchers on individuals with Asperger Syndrome (AS) suggest peculiarities of autobiographical memory (AM). They have shown a personal episodic memory deficit in the absence of a personal semantic memory impairment. The primary aim of this study was to explore AM in individuals with AS, and more specifically to investigate the link between episodic memory, self-awareness, and autonoetic consciousness through language analysis. We asked fifteen adults with AS and fifteen age- and IQ-matched controls to recall autobiographical memories from three life periods. Recorded interviews were processed using Alceste software. We found that participants with AS recalled fewer and less-detailed episodic memories than did controls. A content analysis revealed that family-related vocabulary as well as possessive pronouns was significantly less frequent in AS interviews than in those of controls. In conclusion, our results support the hypothesis that a deficiency of episodic memory may be due to poor awareness of the self in social relationships. Reduced use of possessive pronouns may also indicate less self-investment in life experiences, which would in turn impact recall. 相似文献
79.
Bruno Negri DDS PhD José Luis Calvo‐Guirado DDS PhD MS José Eduardo Maté Sánchez de Val DDS PhD MS Rafael Arcesio Delgado Ruiz DDS PhD MS María Piedad Ramírez Fernández DDS PhD MS Gerardo Gómez Moreno DDS PhD MS Antonio Aguilar Salvatierra DDS PhD Javier Guardia DDS PhD MS Fernando Muñoz Guzón DDS PhD MS 《Clinical implant dentistry and related research》2013,15(6):799-808
Purpose: The aim of this study was to evaluate the early bone response of tapered and cylindrical root form implants with two different surface treatments in fresh extraction sockets after 4 and 8 weeks. Materials and Methods: Surface treatments and implant design comprised (n = 9 each): tapered with dual acid‐etched surface; tapered with dual acid‐etched and sandblasted surface (T DAE SB); cylindrical with dual acid‐etched surface (C DAE); and cylindrical with dual acid‐etched and sandblasted surface (C DAE SB). Implants were placed in the distal sockets of mandibular premolars (2P2,3P3,4P4) of six beagle dogs, remaining in vivo for 4 and 8 weeks. After sacrifice, the implants were subjected to torque to the point of interface fracture and subsequently nondecalcified for histomorphological study. Statistical analysis was performed by a General Linear Model (GLM) analysis of variance model with a significance level of 5%. Results: Torque to interface fracture was significantly greater for the C DAE SB group than for the other groups (p < .001). Histomorphological analysis showed woven bone formation around all implant surfaces at 4 weeks and its replacement by lamellar bone at 8 weeks. Study time (4 or 8 weeks) did not affect torque measures. Conclusions: The double acid‐etched and sandblasted sample surface increased early bone biomechanical fixation of both cylindrical and tapered root form implants. The cylindrical root form implants showed higher torque to interface fracture values when compared with the tapered root form implants. The C DAE SB surface group showed the highest biomechanical fixation values (p < .001). 相似文献
80.